TRENDS IN PRESCRIPTION PATTERN IN MEDICAL INDIAN ICU AND IT’S IMPACT ON PATIENT OUTCOME

VENKAT RAMAN KOLA; MEDA HEMASREE; SHARON ROSE; KISHORE

doi:10.22159/ijpps.2022v14i1.43387

Authors

VENKAT RAMAN KOLA Department of Critical Care Medicine, Yashoda Hospital, SP road, Secunderabad, Telangana, India, 500003 https://orcid.org/0000-0002-6971-1236
MEDA HEMASREE Department of Pharmacy, Anurag Group of Institutions, Venkatapur, Ghatkesar, Medchal, Hyderabad, Telangana, India, 5000088 https://orcid.org/0000-0003-0683-8931
SHARON ROSE Department of Pharmacy, Anurag Group of Institutions, Venkatapur, Ghatkesar, Medchal, Hyderabad, Telangana, India, 5000088 https://orcid.org/0000-0002-8734-7853
KISHORE Department of Pharmacy, Anurag Group of Institutions, Venkatapur, Ghatkesar, Medchal, Hyderabad, Telangana, India, 5000088

DOI:

https://doi.org/10.22159/ijpps.2022v14i1.43387

Keywords:

Prescription pattern, Intensive care unit, Antimicrobial agents

Abstract

Objective: The objective of this study is to evaluate the trends in prescribing pattern in medical ICU concerning patient age, gender, past, and current illness along with comorbidities for the evasion of polypharmacy and to improve patient outcomes.

Methods: A prospective analysis of the case records of patients admitted to the ICU of Yashoda hospital in India was carried out.

Results: 120 patients were evaluated, consisting of 77% male patients. The mean±SD of age is 53.81±14.63. The majority of the study subjects belonged to the age group of 50-67 y (32%) Most common causes for admission to the ICU were Respiratory diseases and Stroke. Diabetes mellitus and Hypertension are the most common co-morbidities identified. The total number of drugs used were 1502 during this study period. The average number of drugs per prescription is 12. The range is between 2-30. The average number of antibiotics per prescription is 3. Commonly prescribed drug classes were the GI agents in 100% of patients, followed by antimicrobial agents (AMAs) in 95.8% of patients. About 42.5% of patients received 3 antibiotics per day. 55 potential drug-drug interactions were interpreted in 46 patients. 30(55%) were moderate interactions 25(45%) were major interactions, which were addressed. De-escalation of antibiotics was seen in 29% of patients while escalation in 13%. The death rate is only 5% in our ICU setting.

Conclusion: This prescription pattern study can provide a framework for continuous prescription audit in the ICU

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