DRUG UTILIZATION BASED ADRs DETECTION OF ANTIBIOTICS PRESCRIBED FOR LRTI IN TERTIARY CARE TEACHING HOSPITAL, NEW DELHI

Md Shamim; Mohammad Daud Ali; Md Sarfaraz Alam; Md Sajid Ali; Sarfaraz Ahmad; Md Salahuddin Ansari

doi:10.22159/ijpps.2018v10i4.23368

Authors

Md Shamim College of Pharmacy, Teerthanker Mahaveer University, Muradabad U.P India
Mohammad Daud Ali Department of pharmacy, Mohammed almana college of health sciences, Abdulrazaq Bin Hammam Street, As Safa, Dammam 34222 KSA
Md Sarfaraz Alam Department of Pharmaceutics, College of Pharmacy, Jazan University, Jazan, KSA
Md Sajid Ali Department of Pharmaceutics, College of Pharmacy, Jazan University, Jazan, KSA
Sarfaraz Ahmad Department of Pharmaceutics, College of Pharmacy, Jazan University, Jazan, KSA
Md Salahuddin Ansari Department of Pharmacy Practice, College of Pharmacy Aldawadmi, Shaqra University, Saudi Arabia

DOI:

https://doi.org/10.22159/ijpps.2018v10i4.23368

Keywords:

Drug utilization Review, Adverse drug reaction (ADR), Lower respiratory tract infection (LRTI), Inpatient, Outpatient

Abstract

Objective: Aim of to present study was to assess drug utilization pattern of antibiotics use in Lower respiratory tract infection and their adverse drug reaction assessment.

Methods: The present study was an observational and prospective study. 110 patients fulfill the inclusion criteria were included in study. Physician prescription records, patient's medication profile types of antibiotics prescribed were recorded and analyzed.

Results: Out of 110 LRTI patients, 74 (67.27%) patients were male and 36(32.72%) patients were female. 72 patients were suffered from bronchitis while 38 patients were suffering from pneumonia. 30 patients were in the age range of 56-65 y, followed by 21 patients who were in the age range of 66-75 y. It has been observed that among all the prescribed antibiotic agent's frequency of Î²-lactam 199(45.53%), quinolones115 (26.27%), macrolides 53(12.12%) chloramphenicol44 (10.06%) sulphonamide 17 (3.89%) and aminoglycosides 9(2.05%) were prescribed to all the patients. Average 3.97 antibiotic agents were prescribed to all the patients. Majority of drugs were given by oral route (68.19%) and Prescriptions are mainly ordered in brand names. The most frequent co-morbid condition was found to be diabetes mellitus (25.45%) followed by hypertension (16.36%) and coronary artery disease (11.81%).45.45%. Only 23 ADRs were detected in 110 patients. The most common culprit was an amoxicillin with clavulanic acid.

Conclusion: The present study provides an overall pattern of antibiotic usage in different patients. The area of concern in the present study is polypharmacy and use of antibiotics in LRTI without following any guideline. ADRs monitoring is also required to prevent noxious effects of drugs by the use of antibiotics.

Downloads

Download data is not yet available.

References

Nagapuri S. Market research on the usage of antibiotics in serious infections. Int J Pharm Pharm Sci 2014;6:371-4.

Shyama K, Rudence AR. Improving antibiotic prescribing pattern and assessment of co-morbidities associated with respiratory tract infections. Int J Pharm Pharm Sci 2017;9:283-6.

Morrissey I, Maher K Williams, L Shackcloth J, Felmingham D Reynolds R. Non-susceptibility trends among Haemophilus influenzae and Moraxella catarrhalis from community-acquired respiratory tract infections in the UK and Ireland, 1999â€“2007. J Antimicrob Chemother 2008;62 Suppl 2:ii97â€“ii103.

Belongia EA, Naimi TS, Gale CM, Besser RE. Antibiotic use and upper respiratory infections: a survey of knowledge, attitudes, and experience in wisconsin and minn-esota. Preventive Med 2002;34:346-52.

Graffelman AW, Neven AK, Cessie SL, Kroes ACM, Springer MP, Broek PJVD. Pathogens involved in lower respiratory tract infections in general practice. Br J Gen Pract 2004;54:15-9.

North Melbourne: Therapeutic Guidelines Limited; 2000.

Jakobsen KA, Melbye H, Kelly MJ, Ceynowa C, Molst S, Hood K Butler C. Influence of CRP testing and clinical findings on antibiotic prescribing in adults presenting with an acute cough in primary care. Scand J Primary Health Care 2010;28:229â€“36.

Currie J, Thomas D, Eliana G. Early Childhood Economic Program; 2001;15:2:213-238.

Nordenberg P, Dominique LM, Otto C. Priority medicine for europe and the world: a public health approach to innovation. Available from: http://mednet3.Who.int/proritymeds/2005. [Last accessed on 20 Nov 2017]

Huchon GJ, Gialdroni-Grassi G, Leophonte P, Mansare F, Schaberg T, Woodhead M. Initial antibiotic therapy for lower respiratory tract infection in the community: a European survey. Eur Respire J 1996;9:1590â€“5.

Guthrie R. Community-acquired lower respiratory tract infections: etiology and treatment. Ther Guidelines: Respiratory 2009;6:503-89.

Pradhan SC, Shewade DG, Tekur U, Zutshi S, Pachiappan D, Dey AK, et al. Changing pattern of antimicrobial utilization in an Indian teaching hospital. Int J Clin Pharmacol Ther Toxicol 1990;28:339-43.

Mathew E, Falagasa B, Eleni GM, Konstantions ZV. Sex differences in the incidence and severity of respiratory tract infections. Respir Med 2007;101:1845-63.

Shankar PR, Upadhyay DK, Subish P, Dubey AK, Mishra P. Prescribing patterns among paediatric inpatients in a teaching hospital in Western Nepal. Singapore Med J 2006;47:261-5.

Dhingra PL. Diseases of ear, nose and throat. 3rd ed. New Delhi: Mosby, Saunders, Elsevier; 2004. p. 62-117.

Mazzaglia G, Greco S, Lando C, Cucinotta G, Caputi AP. Adult acute upper respiratory tract infections in sicily: pattern of antibiotic drug prescription in primary care. J Antimicrob Chemother 1998;41:259-66.

Pandey A, Chaudhry R, Kapoor L, Kabra S. Acute lower respiratory tract infection due to chlamydia species in children under five years of age. Indian J Chest Dis Allied Sci 2005;47:97-101.

Ryan HS. Pattern of drug utilization in acute tonsillitis in a teaching hospital in Nepal. Indian J Otolaryngol Head Neck Surg 2003;3:176-9.