FAMILY ACANTHACEAE AND GENUS APHELANDRA: ETHNOPHARMACOLOGICAL AND PHYTOCHEMICAL REVIEW
Keywords:
Acanthaceae, Aphelandra, Ethnomedicinal, Phytochemistry, Wound healing potentialAbstract
Aphelandra belong to family Acanthaceae. We have reviewed traditional uses, pharmacological potential and phytochemical study of family Acanthaceae and genus Aphelandra. Traditionally the most important part use in Acanthaceae is the leaves and they are used externally for wounds. We have found that Acanthaceae possess antifungal, cytotoxic, anti-inflammatory, anti-pyretic, anti-oxidant, insecticidal, hepatoprotective, immunomodulatory, Anti- platelet aggregation and anti-viral potential. Phytochemical reports on family Acanthaceae are glycosides, flavonoids, benzonoids, phenolic compounds, naphthoquinone and triterpenoids. We have also document genus Aphelandra, its phytochemical and pharmacological potential.
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Mughal TA. Ethnomedicinal studies of flora of Southern Punjab and isolation of biologically active principles: Department of Chemistry Lahore College for Women University, Lahore; 2008.
Muthu C, Ayyanar M, Raja N, Ignacimuthu S. Medicinal plants used by traditional healers in Kancheepuram District of Tamil Nadu, India. J Ethnobiology Ethnomedicine 2006;2:1-10.
Jeruto P, Lukhoba C, Ouma G, Otieno D, Mutai C. An ethnobotanical study of medicinal plants used by the Nandi people in Kenya. J Ethnopharmacol 2008;116:370-6.
Sandhya B, Thomas S, Isabel W, shenbagarathai R. Ethnomedicinal plants used by valaiyan community of piranmalia hills (reserved forest), tmil nadu, india. –a pilot study. Afr J Tradit Complementary Altern Med 2006;3:101-14.
Mia MMK, Kadir MF, Hossan MS, Rahmatullah M. Medicinal plants of Garo tribe inhabiting the Madhupur forest region of Bangladesh. Am-Eur J Sustainable Agriculture 2009;3:165-71.
Ignacimuthu S, Ayyanar M, Sankarasivaraman K. Ethnobotanical study of medicinal plants used by paliyartribals in theni district of tamil nadu, india. Fitoterapia 2008;79:562-8.
Husain SZ, Malik RN, Javaid M, Bibi S. Ethnobotanical properties and uses of medicinal plants of Morgah biodiversity park, rawalpindi. Par J Boany 2008;40:1897-911.
Krishnaraju AV, Rao TVN, Sundararaju D, Vanisree M, Tsay HS, Subbaraju GV. Assessment of bioactivity of indian medicinal plants using brin shrimo (artemiasalina) lethality assay. Int J Appl Sci Eng 2005;3:125-34.
Singha PK, Roy S, Dey S. Antimicrobial activity of Andrographispaniculata. Fitoterapia 2003;74:692-4.
Samy RP. Antimicrobial activity of some medicinal plants from India. Fitoterapia 2005;76:697-9.
Alagesaboopathi C. Antimicrobial potential and phytochemical screening of Andrographisaffis Nees. An endemic medicinal plant from India. Int J Pharm Pharm Sci 2011;3:157-9.
Radhika P, Lakshmi K. Antimicrobial activity of the chloroform exracts of the roots and the stem of andrographispaniculata nees. Int Res J Microbiol 2010;1:037-9.
Bukke S, Raghu PS, Sailaja G, Kedam TR. The study on Morphological, phytochemical and pharmacological aspects of rhinacanthusnasutus. (L) Kurz (A Review). J Appl Pharm Sci 2011;1:26-32.
Rasoamiaranjanahary L, Marstan A, Guilet D, Schenk K, Randimbivololona F, Hostettmann K. Antifungal diterpenes from hypoestesserpens (Acanthaceae). Phytochem 2003;62:333-7.
Radhika P, Lakshmi K. Antimicrobial activity of the chloroform exracts of the roots and the stem of andrographispaniculata nees. Int Res J Microbiology 2010;1:037-9.
Navarro E, Alonso SJ, Trujillo J, Jorge E, Perez C. General Behavior, Txicity, and Cytotoxic Activity of Elenoside, a lignin from Justciahyssopifolia. J Nat Pro 2001;64:134-5.
Susplugas S, Hung NV, Bignon J, Thoison O, Kruczynsk A, Sevenet T, Gueritte F. Cytotoxic arylnaphthalene lignans from a vietnamese acanthaceae, justiciapatentiflora. J Nat Pro 2005;68:737-8.
Kumar RA, Seridevi K, Kumar NV, Nanduri S, Rajagopal S. Anticancer and immunstimulatory compounds from andrographispaniculata. J Ethnopharm 2004;92:291-5.
Nanduri S, Nyavanandi VK, Thunuguntla SSR, Kasu S, Pallerla MK, Ram, et al. Synthesis and structure activity relationship of andrographolide analogues as novel cytotoxic agents. Bioorg Med Chem Lett 2004;14:4711-7.
Patra A, Jha S, Murthy PN, Vaibhav A, Chattopadhyay P, Panigrahi G, et al. Anti-inflammatory and antipyretic activities of Hygrophilaspinosa T. Anders leaves (Acanthaceae). Trop J Pharm Res 2009;8:133-7.
Richard SW, Marus L, Noya S, Pierre GI, Germaine NOO. Ant-inflammatory, analgesic and antipyretic effects of Lepidagathisanobrya Nees (Acanthaceae). Afr J Tradit Complementary Altern Med 2011;8:420-4.
Sawadogo wR, Boly R, Lompo M, Some N, Lamien CE, et al. Anti-inflammatory, analgesic and antipyretic activities of diclipteraverticillata. Int J Pharmacol 2006;2:435-8.
Jothimanivannan C, Kumar RS, Subramanian N. Anti-inflammatory and analgesic activity of ethanol extract of aerial parts of justiciagenarussa burn. Int J Pharmacol 2010;1:1-6.
Khadse CD, Kakde RB. Anti-inflamatory activity of aqueous extract fractions of Barleriaprionitis L. roots. Asian J Plant Sci Res 2011;1:63-8.
Chandrasekaran CV, Gupta A, Agarwal A. Effect of an extract of Andrographispaniculata leaves on inflammatory and allergic mediators in vitro. J Ethnopharmacol 2010;129:203-7.
Jimenez GS, Aquino CR, Martinez LC, Torres KB, Monroy MR. Antioxidant activity and content of Phenolic compounds and flavonoids from Justiciaspicigera. J Biol Sci 2009;9:629-32.
Charoenchai P, Vajrodaya S, Somprasong W, Mahidol C, Ruchirawat S, Kittakoop P. Antiplasmodial, acytotoxic, radical scavenging and antioxidant activities of thai plants in the family acanthaceae. Planta Med 2010;76:1940-43.
Ashour MAG. Isolation, HPLC/UV Characterization and antioxidant activityof phenylethnoids from Blepharisedulis (Forssk.) pers. Growing in Egypt. Bull Faculty Pharm Cairo Univer 2012;50:67-72.
Bhragual DD, Kumar N, Garg VK, Sharma PK. Review on plants having Hepatoprotective activity. J Pharm Res 2010;3:2077-82.
Amin E, Radwan MM, Hawary SSE, Fathy MM, Mohammad R, Becnel JJ, et al. Potent insecticidal secondary metabolites from medicinal plant acanthus montanus. Record Nat Pro 2012;6:301-5.
Kanchanapoom T, Kamel MS, Kasai R, Picheansoonthon G, Hiraga Y, Yamasaki K. Benzoxanoid glucosides from Acanthus ilicifolius. Phytochem 2001;58:637-40.
Kanchanapoom T, Ruchirawat S. Megastigmane glucoside from Asystasiagangetica (L.). J Nat Medicine 2007;61:430-3.
Kanchanapoom T, Noiarsa P, Ruchirawat S, Kasai R, Otsuka H. Triterpinoidal glycosides from Justiciabetonica. Phytochem 2004;65:2613-18.
Mawla AMAAE, Ahmed AS, Ibraheim ZZ, Ernst L. Phenylethnoid glycosides from Barleriacristata L. callus cultures. Bull Pharm Sci 2005;28:199-204.
Noiarsa P, Ruchirawat S, Kanchanapoom T. Acanmontanoside, a new phenyl ethanoid diglycoside from acanthus montanus. Molecules 2010;15:8967-72.
Worawittayanon P, Ruadreo J, Disadee W, Sahakitpichan P, Sitthimonchai S, Thasana N, et al. Iridoid and flavone glycosides from Asystasiagangetica subsp. micrantha and their antioxidant activities. Biochem Systematics Ecol 2012;40:38-42.
Hemalatha K, Hareeka N, Sunitha D. Chemical constituents isolated from leaves of barleriacristata linn. Int J Pharm Bio Sci 2012;3:609-15.
Bumrela SB, Naik SR. Phytochemical and morphoanatimical studies for establishing quality standards of Dipteracanthuspatulus (Jacq.) Nees. Int J Pharm Biomed Res 2011;2:98-103.
Berrondo LF, Gabriel FT, Fernandes SBDO, Menezes FDS. Dirhamnosyl flavonoid and other constituents from Brillantaisiapalisatii. Quim Nova 2003;26:922-3.
Rao YK, Vimalamma G, Rao CV, Tzeng YM. Flavonoids and andrographolides from Andrographispaniculata. Phytochem 2004;65:2317-21.
Hemalatha K, Hareeka N, Sunitha D. Chemical constituents isolated from leaves of barleriacristata linn. Int J Pharma Bio Sci 2012;3:609-15.
Bravo HR, Copaja SV, Lazo W. Antimicrobial activity of Natural 2-Benzoxazolines and related derivatives. J Agricultureand Food Chem 1997;45:3255-7.
Grimes BM, McBeth DL, Hallihan B, Delph S. Antimicrobial activity in medicinal plants of the Scrophulariaceae and Acanthaceae. J Pharm Biol 1996;34:243-8.
Roia FC, Smith RA. The antibacterial screening of some common ornamental plants. Economic Bot 1977;31:28-37.
Kohno k, Miyake M, Sano O, Katoka MT, Yamamota S, Miyata SK, et al. Anti-inflammatory and Immunomodulatory properties of 2-Amino-3-H-phenoxazine. Biology Pharm Bull 2008;31:1938-45.
Zikmundova M, Drandarov K, Bigler L, Hesse M, Werner C. Biotransformation of 2-benzoxazolinone (BOA) and 2-hydroxy-1,4-benzoxazin-3-one (HBOA) by endophytic fungi isolated from Aphelandra tetragona. Appl Environ Microbiol 2002;68:4863-70.
Hedberg C, Hesse M, Werner C. Spermine and spermidine hydroxyl cinnamoyl transeferases in Aphelandra tetragona. Plant Sci 1996;113:149-56.
Warner C, Hu W, Riatsch AL, Hesse M. Di-coumaroylspermidines and Tri-coumaroylsperrmidines in anthers of different species of genus Aphelandra. Phytochem 1995;40:461-5.
Tawil BF, Zhu JP, Piantini U, Hesse M. New spermine alkaloids from aphelandra tetragona (vahl) nees. Helvetica Chimica Acta 2004;72:180-4.
Youhnovski N, Filipov S, Linden A, Guggisberg A, Werner C, Hesse M. Two macrocyclicspermine alkaloids from Aphelandra fuscopunctata (Acanthaceae). Phytochem 1999;52:1717-23.
Baumeler A, Hesse M, Werner C. Benzoxazinoids cyclic hydroxamic acids, lactams and their corresponding glucosides in the genus Aphelandra (Acanthaceae). Phytochem 2000;53:213-22.
Hedberg C, Hesse M, Werner C. Spermine and spermidine hydroxyl cinnamoyl transeferases in Aphelandra tetragona. Plant Sci 1996;113:149-56.
Bratoeff EA, Amador PMC. Phytochemical study of Aphelandra aurantica Scheider (Acanthaceae). Phyton-Int J Exper Bot 1994;56:27-32.