A REVIEW ON PHYTOCHEMICAL CONSTITUENTS AND PHARMACOLOGICAL ACTIVITIES OF CLINACANTHUS NUTANS
Keywords:
Clinacanthus nutans, Anti-viral, Anti-oxidant, Glycosides, Herpes Simplex VirusAbstract
Clinacanthus nutans commonly known as Belalai gajah (Malay), Phaya yo (Thai) is traditionally used medicinal plant. The plant is used in skin rashes, snake bites, lesions caused by herpes simplex virus, diabetic myelitis, fever, diuretics and green tea and served as fresh drink. The phytochemical constituents existing in the plant comprise lupeol, b –sitosterol, stigmasterol, Botulin, myricyl alcohol C-glycosyl flavones (vitexin, isovitexin, shaftoside, isomollupentin 7-O-b -glucopyranoside, orientin and isoorientin),sulfur-containing glucosides, cerebrosides mixer, a monoacylmonogalactosylglycerol,13-hydroxy-(13-S)-phaeophytin b, Pupurin-18-phytyl ester, phaeophorbide and chlorophyll derivatives. Pharmacological studies reported anti-Papillomavirus Infectivity, anti-viral activity on varicella-zoster virus, anti-inflammatory activity, anti-herpes Simplex virus type 1 and type 2 activity, anti-oxidant and protective effect against oxidative induced hemolysis.
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Roosita K, Kusharto CM, Sekiyama M, Fachrurozi Y, Ohtsuka R. Medicinal plants used by the villagers of a Sundanese Community in West Java, Indonesia. J Ethnopharmacol 2008;115:72-81.
Smitinand T. Thai Plant Names (Botanical Names-VernacularNames),†Royal Forest Department, Phahonyothin, Bangkhen, Bangkok, Thailand; 1980. p. 88.
Tropicos. org. Tropicos | Name-Clinacanthus nutans (Burm. f.) Lindau. [online] Available From: http://www.tropicos.org/Name/50058310[Accessed 12 Aug. 2014].
Taxonomic Hierarchy of COL-China 2012. " Clinacanthus nutans." Encyclopedia of Life; Available from; http://eol.org/pages/5634686/names/common_names.[Accessed 12 August 2014].
Flora of China Editorial Committee. Flora of China (Curcurbitaceae through Valerianaceae with Annonaceae and Berberidaceae). In CY Wu, PH Raven, DY Hong (eds.) Fl China. Science Press & Missouri Botanical Garden Press: Beijing & St. Louis; 2011;19:1–884.
Tuntiwachwuttikul P, Pootaeng-on Y, Phansa P, Taylor WC. Cerebrosides and a monoacylmonogalactosyglycerol from Clinacanthus nutans. Chem Pharm Bull 2004;52(1):27-32.
Sakdarat S, Shuyprom A, Dechatiwongse Na Ayudhya T, Waterman PG, Karagianis G. Chemical composition investigation of Clinacanthus nutans Lindau leaves. Thai J Phytopharmacol 2006;13(2):13-24.
Sakdarat S, Shuyprom A, Pientong C, Ekalaksananan T, Thongchai S. Bioactive constituents from the leaves of Clinacanthus nutans Lindau. Bioorg Med Chem 2009;17:1857-60.
P’ng XW, Akowuah GA, Chin JH. Acute oral toxicity study of Clinacanthus nutans in mice. Int J Pharm Sci Res 2012;3:4202-5.
Boongerd K. The Chemical Constituents of Clinacanthus burmanii,†M. Sc. Thesis, Chulalongkorn University, Bangkok, Thailand; 1967.
Dampawan P, Huntrakul C, Reutrakul V, Raston CL, White AH. J Sci Soc Thailand 1996;3:14-26.
Terpenoids Teshima K, Kaneko T, Ohtani K, Kasai R, Lhieochaiphant S, Picheansoonthon C, et al. Natural Medicines 1997;51:557
Teshima K, Kaneko T, Ohtani K, Kasai R, Lhieochaiphant S, Picheansoonthon, et al. Sulfur-containing glucosides from Clinacanthus nutans. Phytochem 1998;48:831-5.
Tuntiwachwuttikul P, Pootaeng-On Y, Phansa P, Taylor WC. Cerebrosides and a onoacylmonogalactosylglycerol from Clinacanthus nutans. Chem Pharm Bull (Tokyo) 2004;52(1):27-32.
Ayudhya TDN, Sakdarat S, Shuyprom A, Du an gpen Pattaraadilok JB, Waterman PG, Karagianis G. Chemi-cal constituents of the leaves of Clinacanthus nutans Lin-dau. Thai J Phytopharm 2001;8(1):1.
Dampawan P. Studies of the chemical constituents of Clinacanthus nutans (Acanthaceae) and Zingiber cassumunar Roxb (Doctoral dissertation, Master thesis, Mahidol University, Bangkok, Thailand; 1976.
Dampawan Pimchit, Huntrakul Charus, Reutrakul Vichai, Raston CL, White A H. Constituents of Clinacanthus nutans and the crystal structure of LUP-20 (29)-ene-3-one. J Sci Soc Thailand 1977;3:14-26.
Lin J, Li HM, Yu JG. Studies on the chemical constituents of niu xu hua (Clinacanthus nutans). Zhongcaoyao 1983;14:337-8.
Janwitayanuchit W, Suwanborirux K, Patarapanich C, Pummangura S, Lipipun V, Vilaivan T. Synthesis and anti-herpes simplex viral activity of monoglycosyl diglycerides. Phytochem 2003;64(7):1253-64.
Sakdarat S, Shuyprom A, Ayudhya TDN, Waterman PG, Karagianis G. Chemical composition investigation of the Clinacanthus nutans Lindau leaves. Thai J Phytopharm 2006;13(2):13-24.
Sakdarat S, Shuyprom A, Pientong C, Ekalaksananan T, Thongchai S. Bioactive constituents from the leaves of clinacanthus nutans Lindau. Bioorg Med Chem 2009;17(5):1857-60.
Lau KW, Lee SK, Chin JH. Effect of the methanol leaves extract of Clinacanthus nutans on the activity of acetylcholinesterase in male mice. J Acute Disease 2014;3(1):22-5.
Haetrakul T, Tangtrongpiros J, Suthamnajpong N, Chansue N. Cytotoxicity concentration of acyclovir and clinacanthus nutans (Burm. f.) lindau extract to koi fin cell line. Thai J Vet Med 2010;108:29-32.
Sookmai W, Ekalaksananan T, Pientong C, Sakdarat S, Kongyingyoes B. The anti-papillomavirus infectivity of Clinacanthus nutans compounds. Srinagarind Med J 2011;26:240-3.
Kittisiripornkul S. The Antiinflammatory Action and Toxicological Studies of Extracts from Clinacanthus nutans,†M. Sc. Thesis, Faculty of Science, Mahidol University, Bangkok, Thailand; 1984.
Jayavasu C, Chavalittumrong P, Polachandara K. Dechatiwongse na ayudhaya t jongtrakulsiri s. Bull Dept Med Sci 1992;34:154-8.
Thawaranantha D, Balachandra K, Jongtrakulsiri S, Chavalittumrong P, Bhumiswasdi J, Jayavasu C. Siriraj Hosp. Gaz Thailand 1992;44:285-91.
Sittiso S, Ekalaksananan T, Pientong C, Sakdarat S, Charoensri N, Kongyingyoes B. Effects of compounds from Clinacanthus nutans on dengue virus type 2 infection. Srinagarind Med J 2010;25:272-5.
Thongchai S, Ekalaksananan T, Pientong C, Aromdee C, Seubsasana S, Sukpol, C, et al. Anti-herpes simplex virus type 1 activity of crude ethyl acetate extract derived from leaves of clinacanthus nutans lindau. J Sci Technol Mahasarakham University 2010;27(4):318-26.
Chavalittumrong P, Attawish A, Rugsamon P, Chuntapet P. Toxicological study of clinacanthus nutans (Burm. f.) Lindau. Bull Dep Med Sci 2013;37(4):323-38.
Jayavasu C, Dechatiwongse T, Balachandra K, Chavalittumrong P, Jongtrakulsiri S. The virucidal activity of clinacanthus nutans lindau extracts against herpes simplex virus type-2: an in vitro study. Bull Dep Med Sci 2013;34(4):153-8.
Pannangpetch P, Laupattarakasem P, Kukongviriyapan V, Kukongviriyapan U, Kongyingyoes B, Aromdee C. Antioxidant activity and protective effect against oxidative hemolysis of Clinacanthus nutans (Burm. f) Lindau. Songklanakarin J Sci Technol 2007;29(1):1-9.
Jayavasu C, Balachadra K, Sangkitjaporn S, Maharungraungrat A. Com. Dis. J. (Thailand) 1992;18:152-61.
Sangkitporn S, Polchan K, Thawatsupa P, Bunchob M, Chawalittumrong P. Bull Dept Med Serv (Thailand) 1993;18:226-31.
Sangkitporn S, Chaiwat S, Balachadra K, Dechatiwongse Na-AyudhayaT, Bunjob M, Jayavasu C. Treatment of herpes zoster with Clinacanthus nutans (bi phaya yaw) extract. J Med Assn Thailand 1995;78:624-7.
Charuwichitratana S, Wongrattanapasson N, Timpatanapong P, Bunjob M. Herpes zoster: treatment with Clinacanthus nutans cream. Int J Dermatol 1996;35:665-6.