DEVELOPMENT AND EVALUATION OF IN SITU NASAL MUCOADHESIVE GEL OF METOPROLOL SUCCINATE BY USING 32 FULL FACTORIAL DESIGN
Keywords:
Metoprolol succinate, Mucoadhesive strength, Carbopol 940, Nasal gelAbstract
Objective: To develop and evaluate in situ nasal mucoadhesive gel of metoprolol succinate.
Methods: In situ nasal mucoadhesive gel was formulated by cold method using Carbopol 940 as a pH sensitive polymer, xanthan gum as a mucoadhesive polymer and PEG 400 as the penetration enhancer. A 32 full factorial designs was successfully applied for the optimization. All the formulated gels were evaluated for different chemical and physical characteristics. In vitro release data were fitted to different models to know exact mechanism of drug release.
Results: All the prepared in situ gel showed good In vitro drug release profile. Carbopol 940 and xanthan gum in higher concentrations were effective in sustaining the release of drug up to 8 hrs. In vitro permeation study showed that optimized F4 batch permeates 95% at 8th hr.
Conclusion: In situ nasal mucoadhesive gel was fond to be effective in sustaining the release of the drug up to 8 hrs hence it could be a useful formulation as a alternative therapy in management of hypertension.
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References
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