MEDICINAL PROPERTIES OF DIFFERENT PARTS OF ACACIA NILOTICA LINN (BABUL), ITS PHYTOCONSTITUENTS AND DIVERSE PHARMACOLOGICAL ACTIVITIES
Medicinal properties and pharmacological activities of A. nilotica
DOI:
https://doi.org/10.22159/ijpps.2020v12i2.35672Keywords:
Acacia nilotica Linn, Analgesic, Antibacterial, Anti-inflammatory, AntioxidantAbstract
Acacia nilotica Linn commonly known as Babul is a multipurpose tree. As the world is turning back towards the herbal drug, it is the need of the hour to re-evaluate the knowledge of traditional medicine through vast review. In the Unani traditional system of medicine, all parts of the plant have been used as a remedy for various diseases and are imputed for their medicinal properties. Hence, this review presents an overview of the medicinal properties of different parts of A. nilotica L. used in Unani medicine, its phytochemical constituents, and diverse pharmacological activities. The information related to this drug was retrieved using the classical Unani sources viz., Al-Qanun fi’l Tibb (Canon of Medicine), Iksir-i-A‘zam, Al Hawi fi’l Tibb (Continens Liber), Tarjuma Kamil al-Sana‘a al-Tibbiyya, Dhakhira Khawarizm Shahi, Biyaz-i-Kabir and Tibb-i-Akbar for medicinal properties used in Unani Medicine. Further for other traditional uses, phytoconstituents and pharmacological activities, different search engines like PubMed, Medline, Google Scholar, Ovid, Science Direct and Scopus were also browsed.
A. nilotica possesses various medicinal properties as per classical Unani texts such as astringent, tonic, wound healing, aphrodisiac, expectorant, resolvent, and antispasmodic. In vivo, in vitro, and clinical studies from the published articles validate the fact that A. nilotica is a potential source of various bioactive compounds having various pharmacological properties and therapeutic uses. The various pharmacological activities are anti-inflammatory, analgesic, antibacterial, anticancerous, antidiabetic and antihypertensive properties. This review concludes that the Unani medicinal effects of A. nilotica are proven by scientific studies.
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Tyagi R, Sharma G, Jasuja ND, Menghani EK. Indian medicinal plants as an effective antimicrobial agent. J Crit Rev 2016;3:69-71.
Bashir HS, Mohammed AM, Magsoud AS, Shaoub AM. Isolation and identification of two flavonoids from Acacia nilotica (Leguminosae) leaves. J Prod Ind 2014;3:211-5.
Rather LJ, Mohammad F. Acacia nilotica (L.): a review of its traditional uses, phytochemistry, and pharmacology. Sustain Chem Pharm 2015;2:12-30.
Sharma AK, Kumar A, Yadav SK, Rahal A. Studies on antimicrobial and immunomodulatory effects of hot aqueous extract of Acacia nilotica L. leaves against common veterinary pathogens. Vet Med Int 2014. http://dx.doi.org/ 10.1155/2014/747042
Rajvaidhya S, Nagori BP, Singh GK, Dubey BK, Desai P, Jain S. A review on Acacia arabica-an Indian medicinal plant. Int J Pharm Sci Res 2012;3:1995-2005.
Sadiq MB, Hanpithakpong W, Tarning J, Anal AK. Screening of phytochemicals and in vitro evaluation of antibacterial and antioxidant activities of leaves, pods and bark extracts of Acacia nilotica (L.) Del. Ind Crops Prod 2015;77:873-82.
Nandkarni KM. Indian Materia Medica (Vol. I). Mumbai: Saurabh Printers; 2009. p. 9-10.
Khare CP. Indian medicinal plants (an illustrated dictionary). New Delhi: Spring Publishers; 2005. p. 4-5.
Prajapati ND, Purohit SS, Sharma AK, Kumar T. A handbook of medicinal plants. Jodhpur: Hinglaj Printer; 2009. p. 5.
Parajapati ND, Kumar DU. Agro’s dictionary of medicinal plants. Jodhpur: Shyam Printing Press; 2005. p. 3.
Kabir al-Din M, Makhzan al-Mufridat. New Delhi: Idarae Kitabus Shifa; 2007. p. 101-2.
Katiyar S, Patidar D, Gupta S, Singh RK, Singh P. Some Indian traditional medicinal plants with antioxidant activity: a review. Int J Innov Res Sci Eng Technol 2013;2:7303-14.
Hakeem MA, Bustan al-Mufridat. New Delhi: Idarae Kitabus Shifa; 2002. p. 120.
Tariq HNA, Taj al Mufridat. New Delhi: Idarae Kitabus Shifa; 2010. p. 595-6.
Ghani N, Khazainul Advia. New Delhi: Idarae Kitabus Shifa; 2001. p. 339-41.
Rafeequddin M, Kinz al-Adwiya Mufridah. Aligarh: University Publication Unit; 1985. p. 148-9.
Kabir Al-Din M, Ilmul Adwiya Nafeesi. New Delhi: I’jaz Publishing House; 2007. p. 645.
Kalaivani T Mathew L. Free radical scavenging activity from leaves of Acacia nilotica (L.) Wild. ex Delile, an Indian medicinal tree. Food Chem Toxicol 2010;8:298-305.
Badshah L, Hussain F. People preferences and use of local medicinal flora in district tank, Pakistan. J Med Plant Res 2011;5:22-9.
Khan A, Muhit-i-A‘zam. Ist ed. (Urdu Trans). New Delhi: Central Council of Research of Unani Medicine; 2012. p. 583-4.
Chopra RN, Nayar SL, Chopra IC. Glossary of Indian Medicinal Plants. New Delhi: Council of Scientific and Industrial Research; 2002. p. 2.
Bansal VK, Goel RK. Gastroprotective effect of Acacia nilotica young seedless pod extract: role of polyphenolic constituents. Asian Pac J Trop Med 2012;5:523-8.
Nabi MG, Makhzan Al-Mufridat wa Murakkabat. New Delhi: Central Council of Research of Unani Medicine; 2007. p. 60.
Sina I, Al-Qanun Fi’l Tibb. (Urdu Trans: Kantoori GH). New Delhi: Idarae Kitabus Shifa; 1981. p. 1065, 1092, 1095.
Ibrahim SB, Kitab Al-Fath, Fi al-Tadawi (Urdu Trans). New Delhi: NCPC Printers; 2007. p. 188.
Seigler D. Phytochemistry of Acacia-sensu lato. Biochem Syst Ecol 2003;31:845-73.
Auwal MS, Saka S, Mairiga IA, Sanda KA, Shuaibu A, Ibrahim A. Preliminary phytochemical and elemental analysis of aqueous and fractionated pod extracts of Acacia nilotica (Thorn mimosa). Vet Res Forum 2014;5:95-100.
Sharma M, Gupta AK, Mukherji A. Invasive Acacia nilotica a problematic weed is a source of potent methyl gallate. Int J Sci Res 2014;3:1193–5.
Singh BN, Singh BR, Singh RL, Prakash D, Sarma BK, Singh HB. Antioxidant and anti-quorum sensing activities of green pod of Acacia nilotica L. Food Chem Toxicol 2009;47:778-86.
Jigam AA, Akanya HO, Dauda BE, Okogun JO. Polygalloyltannin isolated from the roots of Acacia nilotica Del. (Leguminoseae) is effective against Plasmodium berghei in mice. J Med Plants Res 2010;4:1169-75.
Abbasian K, Asgarpanah J, Ziarati P. Chemical composition profile of Acacia nilotica seed growing wild in South of Iran. Orient J Chem 2015;31:1027-33.
Chaubal R, Pawar PV, Hebbalkar GD, Tungikar VB, Puranik VG, Deshpande VH, et al. Larvicidal activity of Acacia nilotica extracts and isolation of D-pinitol-a bioactive carbohydrate. Chem Biodivers 2005;2:684-8.
Sundarraj S, Thangam R, Sreevani V, Kaveri K, Gunasekaran P, Achiraman S, et al. γ-Sitosterol from Acacia nilotica L. induces G2/M cell cycle arrest and apoptosis through c-myc suppression in MCF-7 and A549 cells. J Ethnopharmacol 2012;141:803-9.
Tindale MD, Roux DG. A phytochemical survey of the Australian species of acacia. Phytochemistry 1969;8:1713-27.
Jingade NM, Nagargoje PB, Shirote PJ. Isolation, phytochemical and biological evaluation of Acacia nilotica (L) willd. leaf extract. Int J Pharmacog Phytochem Res 2014;6:179-82.
Anderson DM, Karamal KA. (Studies on uronic acid materials: PartXVI1. Inter-nodule variation and the acidic components in Acacia nilotica gum. Carbohydr Res 1996;2:403–10.
Kapoor VP, Farooqi MI, Taravel FR, Joseleau JP. Studies on Acacia nilotica gum exudates. Structural variation due to different habitats. Carbohydr Res 1991;222:289-93.
Salem MM, Davidorf FH, Abdel-Rahman MH. In vitro anti-uveal melanoma activity of phenolic compounds from the Egyptian medicinal plant Acacia nilotica. Fitoterapia 2011;82:1279-84.
Srivastava M, Kumar G, Mohan G, Malhotra S. Phytochemical studies and antimicrobial activity of Babul seeds. J Sci Ind Res 2014;73:724-8.
Sokeng SD, Koube J, Dongmo F, Sonnhaffouo S, Nkono BL, Taiwe GS, et al. Acute and chronic anti-inflammatory effects of the aqueous extract of Acacia nilotica (L.) del. (Fabaceae) pods. Academia J Med Plants 2013;1:1-5.
Kumar M, Jain S, Dave R. Babul (Acacia nilotica) a potential source of tannin and its suitability in the management of type II diabetes. Food Sci Nutr 2014;44:119-26.
Gmaraldeen SM, Magzoub AA, Badri AM, Garbi MI, Saleh M. Antibacterial activity of Acacia nilotica fruits extract against pathogenic bacteria. Int J Appl Res 2016;2:103-6.
Satish S, Raghavendra MP, Raveesha KA. Evaluation of the antibacterial potential of some plant plants against human pathogenic bacteria. Advan Biol Res 2008;2:44-8.
Das N, Chatterjee P. Evaluation of the antimicrobial potentiality of 50% aqueous ethanolic leaf extract of Acacia nilotica willd. Asian J Pharma Clin Res 2014;7:95-8.
Raheel R, Ashraf M, Ejaz S, Javeed A, Altaf I. Assessment of the cytotoxic and anti-viral potential of aqueous extracts from different parts of Acacia nilotica (Linn) delile against peste des petits ruminants virus. Environ Toxicol Pharmacol 2013;35:72-81.
Asres K, Seyoum A, Veeresham C, Bucar F, Gibbons S. Naturally derived anti-HIV agents. Phytother Res 2005;19:557-81.
Kirtikar KR, Basu BD. Indian medicinal plants. Vol II. 2nd ed. Dehradun: International Book Distributors; 2006. p. 922-4.
Eldeen IM, Van Heerden FR, Van Staden J. In vitro biological activities of niloticane, a new bioactive cassane diterpene from the bark of Acacia nilotica subsp. Kraussiana J Ethnopharmacol 2010;128:555-60.
Dafallah AA, Al-Mustafa Z. Investigation of the anti-inflammatory activity of Acacia nilotica and Hibiscus sabdariffa. Am J Chin Med 1996;24:263-9.
Meena PD, Kaushik P, Shukla S, Soni AK, Kumar M, Kumar A. Anticancer and antimutagenic properties of Acacia nilotica (Linn.) on 7, 12-dimethylbenz(a)anthracene-induced skin papillamagenesis in swiss albino mice. Asian Pac J Cancer Prev 2006;7:627-32.
Singh R, Singh B, Singh S, Kumar N, Kumar S, Arora S. Umbelliferone–an antioxidant isolated from Acacia nilotica (L.) willd. ex. del. Food Chem 2010;120:825-30.
Amos S, Akah PA, Odukwe CJ, Gamaniel KS, Wambede C. The pharmacological effects of an aqueous extract from Acacia nilotica seeds. Phytother Res 1999;13:683-5.
Abuelgassim OA. Antioxidant potential of date palm leaves and Acacia nilotica fruit in comparison with other four common Arabian medicinal plants. Life Sci J 2013;410:3405-10.
de Souza NB, Carmo AM, da Silva AD, Franca TC, Krettli AU. Antiplasmodial activity of chloroquine analogs against chloroquine-resistant parasites, docking studies and mechanism of drug action. Malar J 2014;13:469.
Sadiq MB, Tharaphan P, Chotivanich K, Tarning J, Anal K. In vitro antioxidant and antimalarial activities of leaves, pods and bark extracts of Acacia nilotica (L.) del. BMC Complement Altern Med 2017;17:372.
Alli LA, Nafiu MO, Adesokan AA, Akanji MA, Tijani AY, Salawu QA. Antipyretic and analgesic activities of aqueous extract of Acacia nilotica root. Biokemistri 2014;26:55-62.
Ingkaninan K, Temkitthawon P, Chuenchom K, Yuyaem T, Thongnoi W. Screening for acetylcholinesterase inhibitory activity in plants used in Thai traditional rejuvenating and neurotonic remedies. J Ethnopharmacol 2003;89:261-4.
Eldeen IM, Elgorashi EE, Van Staden J. Antibacterial, anti-inflammatory, anti-cholinesterase and mutagenic effects of extracts obtained from some trees used in South African traditional medicine. J Ethnopharmacol 2005;102:457-64.
Adsersen A, Gauguin B, Gudiksen L, Jager AK. Screening of plants used in Danish folk medicine to treat memory dysfunction for acetylcholinesterase inhibitory activity. J Ethnopharmacol 2006;104:418–22.
Bachaya HA, Iqbal Z, Khan MN, Sindhu ZU, Jabbar A. Anthelmintic activity of Ziziphus nummularia (bark) and Acacia nilotica (fruit) against Trichostrongylid nematodes of sheep. J Ethnopharmacol 2009;123:325-9.
Misar A, Bhagat R, Mujumdar AM. Antidiarrhoeal activity of Acacia nilotica Willd. bark methanol extract. Hindustan Antibiot Bull 2008;49:14-20.
Jang S, Jang BH, Ko Y, Sasaki Y, Park JS, Hwang EH, et al. Herbal medicines for treating metabolic syndrome: a systematic review of randomized controlled trials. Evid Based Complement Altern Med 2016;2016:5936402.
Kumari M, Jain S, Dave R. Babul (Acacia nilotica) a potential source of tannin and its suitability in management of type II diabetes. Nutr Food Sci 2014;44:116–9.
Asad M, Munir TA, Afzal N. Acacia Nilotica leave extract and glyburide: comparison of fasting blood glucose, serum insulin, β-thromboglubulin levels, and platelet aggregation in streptozotocin-induced diabetic rats. J Pak Med Assoc 2011;61:247–51.
Hegazy GA, Alnoury AM, Gad HG. The role of Acacia arabica extract as an antidiabetic, antihyperlipidemic, and antioxidant in streptozotocin-induced diabetic rats. Saudi Med J 2013;34:727-33.
Gilani AH, Shaheen F, Zaman M, Janbaz KH, Shah BH, Akhtar MS. Studies on antihypertensive and antispasmodic activities of methanol extract of Acacia nilotica pods. Phytother Res 1999;13:665-9.
Lompo Ouedraogo Z, Van Der Heide D, Van Der Beek EM, Swarts HJ, Mattheij JA, Sawadogo L. Effect of aqueous extract of Acacia nilotica sp adansonii on milk production and prolactin release in the rat. J Endocrinol 2004;182:257-66.
Ullah S, Khan MR, Shah NA, Shah SA, Majid M, Farooq MA. Ethnomedicinal plant use-value in the Lakki Marwat District of Pakistan. J Ethnopharmacol 2014;158:412-22.
Krishna PR, Bhaduri L, Pulla S, Nagarjuna S, Padmanabha RY. Comparative study of Acacia nilotica and Acacia sinuata for diuretic activity. Pharm Sin 2011;2:17-22.
Pradeep AR, Happy D, Garg G. Short-term clinical effects of commercially available gel containing Acacia arabica: a randomized controlled clinical trial. Aust Dent J 2010;55:65-9.
Pradeep AR, Agarwal E, Bajaj P, Naik SB, Shanbhag N, Uma SR. Clinical and microbiological effects of commercially available gel and powder containing Acacia arabica on gingivitis. Aust Dent J 2012;57:312-8.
Farzana MUZN, Shameem I, Sultana A. Efficacy of Acacia arabica in improving woman’s quality of life in uterine prolapse: a randomized controlled trial. Sri Lanka J Indigenous Med 2012;2:101-6.
Mustafa S. Efficacy of herbal formulation (Containing Acacia arabica and Butea frondosa) in the treatment of post-natal backache. Paripex Indian J Res 2016;5:35-6.
Singhal R, Agarwal V, Rastogi P, Khanna R, Tripathi S. Efficacy of Acacia arabica gum as an adjunct to scaling and root planing in the treatment of chronic periodontitis: a randomized controlled clinical trial. Saudi Dent J 2018;30:53-62.
Jahufer R, Begum W. Efficacy of bark of Acacia arabica in management of bacterial vaginosis: a randomized controlled trial. Int J Cur Res Rev 2014;6:79-81.
Saeedi R, Sultana A. Effect of Abzan of Samar Babool in Sayalan al-Rahim-A randomized controlled study [dissertation]. Karnataka: Rajiv Gandhi University of Health Sciences; 2019.
Elamin S, Alkhawaja MJ, Bukhamsin AY, Idris MA, Abdelrahman MM, Abutaleb NK, et al. Gum arabic reduces C-reactive protein in chronic kidney disease patients without affecting urea or indoxyl sulfate levels. Int J Nephrol 2017. Doi: 10.1155/2017/9501470
Kannan N, Sakthivel KM, Guruvayoorappan C. Protective effect of Acacia nilotica (L.) against acetaminophen-induced hepatocellular damage in wistar rats. Adv Pharmacol Sci 2013. http://dx.doi.org/10.1155/2013/987692
Mohan S, Thiagarajan K, Chandrasekaran R, Arul J. In vitro protection of biological macromolecules against oxidative stress and in vivo toxicity evaluation of Acacia nilotica (L.) and ethyl gallate in rats. BMC Complement Altern Med 2014;14:257.
El-Hadiyah TM, Abdulhadi NH, Badico EE, Mohammed EY. Toxic potential of ethanolic extract of Acacia nilotica (Garad) in rats. Sudan J Med Sci 2011;6:1-6.
Al-Mustafa ZH, Dafallah AA. A study on the toxicology of Acacia nilotica. Am J Chin Med 2000;28:123-9.
Medani AB, Samia MA, Ahmed EA. Toxicity of Acacia nilotica (Garad) to Nubian Goats. J Toxicol 2016;1:1-5.