• SEPSINA RESKI Department of Nutrition Science, Faculty of Medicine, Diponegoro University, Semarang 50275, Indonesia https://orcid.org/0000-0002-9274-356X
  • FARMADITYA E. P. MUNDHOFIR Department of Histology, Faculty of Medicine, Diponegoro University, Semarang, 50275, Indonesia
  • ETISA ADI MURBAWANI Department of Nutrition Science, Faculty of Medicine, Diponegoro University, Semarang 50275, Indonesia
  • YORA NINDITA Department of Pharmacology and Therapeutics, Faculty of Medicine, Diponegoro University, Semarang 50275, Indonesia
  • MUFLIHATUL MUNIROH Department of Physiology, Faculty of Medicine, Diponegoro University, Semarang, 50275, Indonesia
  • FRONTHEA SWASTAWATI Department of Fisheries Post Harvest Technology Marine Science, Diponegoro University, Semarang 50275, Indonesia
  • ENDANG MAHATI Department of Pharmacology and Therapeutics, Faculty of Medicine, Diponegoro University, Semarang 50275, Indonesia




Catfish oil, Pangasius hypophthalmus, Stunting, Undernourished, Hs-CRP, Transthyretin


Objective: This study aimed to evaluate the effect of catfish (Pangasius hypophthalmus) oil on hs-CRP and transthyretin levels of undernourished Wistar rats.

Methods: Thirty male Wistar rats were divided into five equal groups. Healthy control (KN) is normal rats that consumed a standard diet only and negative control (K-) is undernourished rats that consumed a protein-free diet only. Undernourished rats that consumed a protein free diet and catfish (Pangasius hypophthalmus) oil at doses 0.020 ml/200 g-body-weight/d, 0.040 ml/200 g-body-weight/d and 0.060 ml/200 g-body-weight/d were classified to P1, P2 and P3 groups, respectively. Hs-CRP is a parameter to evaluate inflammatory condition. Transthyretin and body weight are parameters for measuring nutritional status.

Results: Treatment of catfish (Pangasius hypophthalmus) oil on P3 group significantly increases body weight of rats (p<0.05) compare to K-, P1 and P2 groups. There were significant difference of hs-CRP levels in P1, P2 and P3 groups (p<0.05) compare to K-. Hs-CRP levels in P1, P2 and P3 groups compared lower to K-but higher than KN. The mean value of hs-CRP levels in the P3 group (dose 0.060 ml/200 g-body-weight/d) was lower than the other treatment groups. Otherwise, there were no significant difference of TTR levels in P1, P2 and P3 group (p>0.05) compared to K-.

Conclusion: The present study showed that catfish (Pangasius hypophthalmus) oil has the potential effect to increase body weight and reduce inflammatory biomarker (hs-CRP) levels but has no effect to increase TTR levels in undernourished Wistar rats.


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How to Cite

RESKI, S., F. E. P. MUNDHOFIR, E. A. MURBAWANI, Y. NINDITA, M. MUNIROH, F. SWASTAWATI, and E. MAHATI. “EFFICACY OF CATFISH (PANGASIUS HYPOPHTHALMUS) OIL TO OVERCOME STUNTING BY REDUCING INFLAMMATORY CONDITION”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 13, no. 5, May 2021, pp. 18-22, doi:10.22159/ijpps.2021v13i5.40357.



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