ANTICANCER POTENTIAL OF SALACIA CHINENSIS L. AND WOODFORDIA FRUTICOSA (L.) KURZ OF THE WESTERN GHATS FORESTS OF INDIA

NINADA KC; BHAGYA N.; RODRIGUES WJ; CHANDRASHEKAR R.; CHANDRASHEKAR K. R.

doi:10.22159/ijpps.2023v15i12.49198

Authors

NINADA KC Department of Pharmacology, A J Institute of Medical Sciences and Research, Mangalore, DK, India https://orcid.org/0009-0001-4492-813X
BHAGYA N. Department of Applied Botany, Mangalore University, Mangalagangotri, Mangalore-574199, India. Yenepoya Research Centre, Yenepoya (Deemed to be University) Deralakatte, Mangalore-574018, India https://orcid.org/0000-0001-6732-5772
RODRIGUES WJ Department of Applied Botany, Mangalore University, Mangalagangotri, Mangalore-574199, India. Department of Biochemistry, Mangalore University, Mangalagangotri, Mangalore-574199, India https://orcid.org/0009-0007-9750-1440
CHANDRASHEKAR R. Department of Pharmacology, A J Institute of Medical Sciences and Research, Mangalore, DK, India
CHANDRASHEKAR K. R. Department of Applied Botany, Mangalore University, Mangalagangotri, Mangalore-574199, India. Yenepoya Ayush and Pharmacy Research Centre, Yenepoya (Deemed to be University), Mangalore-574018, India https://orcid.org/0000-0002-7511-1851

DOI:

https://doi.org/10.22159/ijpps.2023v15i12.49198

Keywords:

Salacia chinensis, Woodfordia fruticosa, Breast cancer, Pancreatic cancer, Phytochemical, Cytotoxicity

Abstract

Objective: Salacia chinensis and Woodfordia fruticosa are medicinal plants from the Western Ghats of India traditionally used in the treatment of diabetes, diarrhea and worm infections. The current study aims to evaluate the cytotoxic potential of methanolic extract of Salacia chinensis and Woodfordia fruticosa against breast and pancreatic cancers.

Methods: Methanolic extract of dried leaves of Salacia chinensis and Woodfordia fruticosa were obtained by Soxhlet extraction. The cytotoxic potential of the dried extract was evaluated against human breast (MDA-MB-231) and pancreatic (PANC-1) cancers in vitro using MTT-based assay.

Results: The study showed a dose-dependent cytotoxicity of Salacia chinensis and Woodfordia fruticosa leaf extracts against breast and pancreatic cancers with IC₅₀ values of 124 μg/ml against MDA-MB-231 and 230.5 μg/ml against PANC–1 cells, respectively.

Conclusion: Results indicate the presence of cytotoxic phytochemicals in Salacia chinensis and Woodfordia fruticosa. Further purification of the extract might be beneficial to isolate the anticancer phytochemical.

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References

Siegel RL, Miller KD, Wagle NS, Jemal A. Cancer statistics, 2023. CA Cancer J Clin. 2023;73(1):17-48. doi: 10.3322/caac.21763, PMID 36633525.

Deo SVS, Sharma J, Kumar S. GLOBOCAN 2020 report on global cancer burden: challenges and opportunities for surgical oncologists. Ann Surg Oncol. 2022;29(11):6497-500. doi: 10.1245/s10434-022-12151-6, PMID 35838905.

Choudhari AS, Mandave PC, Deshpande M, Ranjekar P, Prakash O. Phytochemicals in cancer treatment: from preclinical studies to clinical practice. Front Pharmacol. 2019;10:1614. doi: 10.3389/fphar.2019.01614, PMID 32116665.

Bhagya N, Chandrashekar KR. Identification and quantification of cytotoxic phenolic acids and flavonoids in Ixora brachiata by UHPLC-DAD and UHPLC-ESI-MS/MS. Int J Mass Spectrom. 2020;450:116290. doi: 10.1016/j.ijms.2020.116290.

Wang X, Zhang H, Chen X. Drug resistance and combating drug resistance in cancer. Cancer Drug Resist. 2019;2(2):141-60. doi: 10.20517/cdr.2019.10, PMID 34322663.

Housman G, Byler S, Heerboth S, Lapinska K, Longacre M, Snyder N. Drug resistance in cancer: an overview. Cancers (Basel). 2014;6(3):1769-92. doi: 10.3390/cancers6031769, PMID 25198391.

Rueff J, Rodrigues AS. Cancer drug resistance: a brief overview from a genetic viewpoint. Methods Mol Biol. 2016;1395:1-18. doi: 10.1007/978-1-4939-3347-1_1, PMID 26910065.

Holohan C, Van Schaeybroeck S, Longley DB, Johnston PG. Cancer drug resistance: an evolving paradigm. Nat Rev Cancer. 2013;13(10):714-26. doi: 10.1038/nrc3599, PMID 24060863.

Gordaliza M. Natural products as leads to anticancer drugs. Clin Transl Oncol. 2007;9(12):767-76. doi: 10.1007/s12094-007-0138-9, PMID 18158980.

Saklani A, Kutty SK. Plant-derived compounds in clinical trials. Drug Discov Today. 2008;13(3-4):161-71. doi: 10.1016/j.drudis.2007.10.010, PMID 18275914.

Gerson Cwilich R, Serrano Olvera A, Villalobos Prieto A. Complementary and alternative medicine (CAM) in Mexican patients with cancer. Clin Transl Oncol. 2006;8(3):200-7. doi: 10.1007/s12094-006-0011-2, PMID 16648120.

Tascilar M, De Jong FA, Verweij J, Mathijssen RHJ. Complementary and alternative medicine during cancer treatment: beyond innocence. Oncologist. 2006;11(7):732-41. doi: 10.1634/theoncologist.11-7-732, PMID 16880232.

Molassiotis A, Browall M, Milovics L, Panteli V, Patiraki E, Fernandez Ortega P. Complementary and alternative medicine use in patients with gynecological cancers in Europe. Int J Gynecol Cancer. 2006;16(1)Suppl 1:219-24. doi: 10.1111/j.1525-1438.2006.00309.x, PMID 16515594.

Taher ZM, Agouillal F, R LJ, Marof AQ, Dailin DJ, Nurjayadi M. Anticancer molecules from Catharanthus roseus. Indonesian J Pharm. 2019;30(3):147. doi: 10.14499/indonesianjpharm30iss3pp147.

Solowey E, Lichtenstein M, Sallon S, Paavilainen H, Solowey E, Lorberboum-Galski H. Evaluating medicinal plants for anticancer activity. ScientificWorldJournal. 2014;2014:721402. doi: 10.1155/2014/721402, PMID 25478599.

Kumar D, Sharma M, Sorout A, Saroha K, Verma S. Woodfordia fruticosa Kurz: a review on its botany, chemistry and biological activities. J Pharmacogn Phytochem. 2016;5(3):293-8.

Bhagya N, Chandrashekar KR. In vitro pharmacological potential of Epiprinus mallotiformis -an endemic species of Western Ghats. IJNPR. 2018;9(2):108-16.

Deokate UA, Khadabadi SS, Hamza AA, Hassanin SO, Hamza S. Phytopharmacological aspects of Salacia chinensis. J Pharmacogn Phytother. 2012;4:1-5.

Wayal SR, Gurav SS. Pharmacognostic and phytochemical investigation of potentially important plants of Western Ghats, India. Int J Pharm Sci Res. 2019;10(6):3101-8.

Giri S, Dey G, Sahu R, Paul P, Nandi G, Dua TK. Traditional uses, phytochemistry and pharmacological activities of woodfordia fruticosa (L) kurz: a comprehensive review. Indian J Pharm Sci. 2023;85(1):1-12. doi: 10.36468/pharmaceutical-sciences.1062.

Minh TT, Hoang Anh NT, Thang VD, Van Sung T. Study on chemical constituents and cytotoxic activities of salacia chinensis growing in vietnam. Zeitschrift fur Naturforschung B. 2010;65(10):1284-8. doi: 10.1515/znb-2010-1017.

Nitha A, Prabha SP, Ansil PN, Latha MS. Antiproliferative effect of Woodfordia fruticosa Kurz flowers on experimentally induced hepatocellular carcinoma in rats and in human hepatoma cell line. J Pharm Res. 2013;6(2):239-48. doi: 10.1016/j.jopr.2013.02.003.

Baravalia Y, Vaghasiya Y, Chanda S. Brine shrimp cytotoxicity, anti-inflammatory and analgesic properties of Woodfordia fruticosa kurz flowers. Iran J Pharm Res. 2012;11(3):851-61. PMID 24250512.

Gamble JS. Flora of the presidency of madras, Vol. Calcutta, India: Sri Gouranga Press Pvt. Ltd; 1958. p. I-III.

Khalid M, Amayreh M, Sanduka S, Salah Z, Al-Rimawi F, Al-Mazaideh GM. Assessment of antioxidant, antimicrobial, and anticancer activities of Sisymbrium officinale plant extract. Heliyon. 2022;8(9):e10477. doi: 10.1016/j.heliyon.2022.e10477, PMID 36105455.

Musini A, Rao JP, Giri A. Phytochemicals of Salacia oblonga responsible for free radical scavenging and antiproliferative activity against breast cancer cell lines (MDA-MB-231). Physiol Mol Biol Plants. 2015;21(4):583-90. doi: 10.1007/s12298-015-0317-z, PMID 26600684.

Augusti KT, Joseph P, Babu TD. Biologically active principles isolated from Salacia oblonga Wall. Indian J Physiol Pharmacol. 1995;39(4):415-7. PMID 8582758.

Choi J, Park JG, Ali MS, Choi SJ, Baek KH. Systematic analysis of the anticancer agent taxol-producing capacity in Colletotrichum species and use of the species for taxol production. Mycobiology. 2016;44(2):105-11. doi: 10.5941/MYCO.2016.44.2.105, PMID 27433121.

ANTICANCER POTENTIAL OF SALACIA CHINENSIS L. AND WOODFORDIA FRUTICOSA (L.) KURZ OF THE WESTERN GHATS FORESTS OF INDIA

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