DESIGN AND DEVELOPMENT OF NANOEMULSION OF SMILAX CHINA FOR ANTI-PSORIASIS ACTIVITY

VISHAL BODKE; PRADNYA KUMBHAR; SHREEYA BELWALKAR; AKASH S. MALI; KARISHMA WAGHMARE

doi:10.22159/ijpps.2024v16i5.50327

Authors

VISHAL BODKE Department of Pharmaceutics, Konkan Gyanpeeth Rahul Dharkar College of Pharmacy and Research Institute, Karjat, Maharashtra, India https://orcid.org/0009-0006-9342-0689
PRADNYA KUMBHAR Department of Drug Regulatory Affairs, Poona College of Pharmacy, Bharati Vidyapeeth University, Pune, Maharashtra, India https://orcid.org/0000-0002-7588-5064
SHREEYA BELWALKAR Sinhgad Institute of Pharmaceutical Science, Lonavala, Maharashtra, India
AKASH S. MALI Faculty of Science, Charles University, Prague, Czechia https://orcid.org/0000-0002-6539-7147
KARISHMA WAGHMARE Department of Pharmaceutical Chemistry, Shri D. D. Vispute College of Pharmacy and Research Center, New Panvel, Maharashtra, India https://orcid.org/0009-0003-7935-1726

DOI:

https://doi.org/10.22159/ijpps.2024v16i5.50327

Keywords:

Smilax china, Tween80, High-speed homogenization method, Antipsoriatic, Nanoemulsion

Abstract

Objective: The present investigation aimed to prepare a smilax china loaded nanoemulsion using tween 80 as a surfactant and propylene glycol as a co-surfactant. Formulation of such drugs in nanoparticulate drug delivery will be advantageous for reducing dosing frequency, longer residence time, improved permeation, and patient compliance.

Methods: High-speed homogenization method. The smilax china oil was prepared by collecting the extract of smilax china leaves into the coconut oil and then used as a solvent. The authentication studies of smilax china and coconut oil were evaluated for their organoleptic and physicochemical characteristics. The quantitative estimation and pre-formulation study of quercetin was carried out which has major anti-psoriatic properties. Surfactant and co-surfactant were selected and the solubility studies of oil and Surfactants were done. The nanoemulsion was characterized by particle size, polydispersity index, zeta potential, and entrapment efficiency (%).

Results: This nanoemulsion provides the particle size and entrapment efficiency range between 80.52 to 89.78 nm and 68.66 to 70.16 % respectively. Batch SC1 showed the lowest particle size, PDI, and optimized drug entrapment effectiveness (%), indicating good particle size consistency within the remaining formulation batches. The optimized formulation SC 1 was found to be stable for 90 d.

Conclusion: The formulated nanoemulsion showed significant antipsoriasis activity due to the presence of quercetin which has a rhetorical yield of 1.066 mg per 5 gm powder of smilax china leaves. Formulated smilax china-loaded nanoemulsion, has the potential as an effective antipsoriasis agent with a good spreading property with faster absorption which is beneficial for reducing drug concentration with maximum therapeutic effect.

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