EVALUATION OF ANTI-INFLAMMATORY ACTIVITY OF AQUEOUS EXTRACT OF MIMOSA PUDICA ON SWISS ALBINO MOUSE

Abstract

Objective: To evaluate the acute anti-inflammatory activity of Aqueous Extract of Mimosa pudica (AEMP) on carrageenan induced paw edema on Swiss albino mouse and to compare the histopathology findings of control, standard and treated Paws of mouse

Methods: 24 Albino mice (20 ± 2g) were divided into 6 groups. Anti-inflammatory activity using carrageenan induced paw edema method and histopathological examination of paw volumes were measured at various intervals on Day 1. Aspirin was taken as the standard drug, three different doses (100mg/kg, 200mg/kg and 400mg/kg) of AEMP were taken as test drug. Left paw of mouse was considered as control. Statistical analyses were done using Analysis of Variance (ANOVA) followed by Tukey’s multiple comparison tests, p-value <0.05 was considered for significant difference.

Results: AEMP showed significant anti-inflammatory activity at all doses (100, 200,400mg/kg) when compared to carrageenan induced group. The study showed that test drug AEMP at the dose of 400mg/kg produced maximum reduction of paw edema at 4 hours. The reduction in paw edema of mice was lower in the 1 hour and showed maximum reduction at 4 hours. The AEMP significant (p≤0.05) anti-inflammatory activities in a dose dependant manner to that of the standard drug Aspirin.

Conclusion: The study suggests that AEMP has anti-inflammatory property and can be used in the treatment of pain. However, further study is necessary in this regard.