A SIMPLE AND A CHEAP UV SPECTROPHOTOMETRIC ASSAY METHOD DEVELOPMENT AND VALIDATION OF DABIGATRN ETEXILATE IN CAPSULES

Authors

  • P. Sowndarya Jawaharlal Nehru technological University, Hyderabad (JNTUH)
  • K. Mounika Jawaharlal Nehru technological University, Hyderabad (JNTUH)
  • S. Laxmi Prasanna Jawaharlal Nehru technological University, Hyderabad (JNTUH)
  • K. Sandya Jawaharlal Nehru technological University, Hyderabad (JNTUH)
  • K. Sandya Jawaharlal Nehru technological University, Hyderabad (JNTUH)
  • A. Ashok Kumar Department of Pharmaceutical analysis and Quality Assurance, Vijaya college of pharmacy, Munaganur (village), Hayathnagar (mandal), Hyderabad 501511, India

Keywords:

UV, Dabigatrn etexilate, method development, validation

Abstract

Objective: To develop a simple and cheap UV spectrophotometric method for the quantitative estimation of Dabigatrn etexilate (150mg) in capsules and validate as per ICH guidelines.

Method: The optimized method uses 0.05N HCl as a solvent for the estimation of assay of Dabigatrn etexilate in capsules at a wavelength of 325 nm.

Results: The developed method resulted in Dabigatrn etexilate exhibiting linearity in the range 5-15μg/ml. The assay precision is exemplified by relative standard deviation of 1.4%. Percentage Mean recovery was found to be in the range of 98â€102, during accuracy studies.

Conclusion:  A simple and a cheap UV spectrophotometric method was developed and validated for the quantitative estimation of Dabigatrn etexilate in capsules as per ICH guidelines and hence it can be used for the routine analysis in various pharmaceutical industries.

 

 

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Author Biographies

P. Sowndarya, Jawaharlal Nehru technological University, Hyderabad (JNTUH)

M.Pharmacy student, department of Pharmaceutical Analysis and Quality assurance

K. Mounika, Jawaharlal Nehru technological University, Hyderabad (JNTUH)

M.Pharmacy student, department of Pharmaceutical Analysis and Quality assurance

S. Laxmi Prasanna, Jawaharlal Nehru technological University, Hyderabad (JNTUH)

M.Pharmacy student, department of Pharmaceutical Analysis and Quality assurance

A. Ashok Kumar, Department of Pharmaceutical analysis and Quality Assurance, Vijaya college of pharmacy, Munaganur (village), Hayathnagar (mandal), Hyderabad 501511, India

Professor and Head of the department of Pharmaceutical Analysis and Quality assurance

 

References

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Published

01-08-2015

How to Cite

Sowndarya, P., K. Mounika, S. L. Prasanna, K. Sandya, K. Sandya, and A. A. Kumar. “A SIMPLE AND A CHEAP UV SPECTROPHOTOMETRIC ASSAY METHOD DEVELOPMENT AND VALIDATION OF DABIGATRN ETEXILATE IN CAPSULES”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 8, no. 8, Aug. 2015, pp. 282-5, https://journals.innovareacademics.in/index.php/ijpps/article/view/6340.

Issue

Vol 7, Issue 8, 2015

Section

Original Article(s)

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