A SIMPLE AND A CHEAP UV SPECTROPHOTOMETRIC ASSAY METHOD DEVELOPMENT AND VALIDATION OF DABIGATRN ETEXILATE IN CAPSULES
Keywords:
UV, Dabigatrn etexilate, method development, validationAbstract
Objective: To develop a simple and cheap UV spectrophotometric method for the quantitative estimation of Dabigatrn etexilate (150mg) in capsules and validate as per ICH guidelines.
Method: The optimized method uses 0.05N HCl as a solvent for the estimation of assay of Dabigatrn etexilate in capsules at a wavelength of 325 nm.
Results: The developed method resulted in Dabigatrn etexilate exhibiting linearity in the range 5-15μg/ml. The assay precision is exemplified by relative standard deviation of 1.4%. Percentage Mean recovery was found to be in the range of 98â€102, during accuracy studies.
Conclusion:Â A simple and a cheap UV spectrophotometric method was developed and validated for the quantitative estimation of Dabigatrn etexilate in capsules as per ICH guidelines and hence it can be used for the routine analysis in various pharmaceutical industries.
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References
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