ACTIVITY SALIVARY BACTERIA OF ACUTE LYMPHOBLASTIC LEUKEMIA CHILDREN IN CHEMOTHERAPY PHASE

Aliyah Abdul Muthalib; Sarworini B.Budiardjo; Margaretha Suharsini

doi:10.22159/ajpcr.2018.v11i3.23274

Authors

Aliyah Abdul Muthalib Department of Pediatric Dentistry, Faculty of Dentistry, Universitas Indonesia, Jakarta - 10430, Indonesia.
Sarworini B.Budiardjo Department of Pediatric Dentistry, Faculty of Dentistry, Universitas Indonesia, Jakarta - 10430, Indonesia.
Margaretha Suharsini Department of Pediatric Dentistry, Faculty of Dentistry, Universitas Indonesia, Jakarta - 10430, Indonesia.

DOI:

https://doi.org/10.22159/ajpcr.2018.v11i3.23274

Keywords:

Activity bacteria, Streptococcus mutans, ALL, Chemotherapy phase

Abstract

Â Objective: The objective of this study was to investigate the differences activity of salivary Streptococcus mutans bacteria in children suffer acute lymphoblastic leukemia (ALL) in phase of chemotherapy, induction, intensification/consolidation, and maintenance.

Methods: This study was a laboratory observational, and cross-sectional method, conducted 19 ALL children in phase of chemotherapy, induction, intensification/consolidation, and maintenance. 2 mm of dental plaque was collected from mesiobuccal first permanent molar and incubated for 48 h at 37Â°C, and the bacterial activity of S. mutans measured by Cariostat.

Results: Odds ratio analysis among chemotherapy phase of induction, intensification/consolidation, and maintenance is not significant (p>0.05) differences.

Conclusion: The highest activity bacteria of S. mutans were found in the induction phase

Downloads

Download data is not yet available.

Author Biographies

Sarworini B.Budiardjo, Department of Pediatric Dentistry, Faculty of Dentistry, Universitas Indonesia, Jakarta - 10430, Indonesia.

Department of Pediatric Dentistry

Margaretha Suharsini, Department of Pediatric Dentistry, Faculty of Dentistry, Universitas Indonesia, Jakarta - 10430, Indonesia.

Department of Pediatric Dentistry

References

Pui CH, Robison LL, Lock AT. Acute lymphoblastic leukemia. Lancet 2008;371:1030-43.

Gupta M, Dahiya J, Marwaha RK, Dureja H. Therapies in cancer treatment: An overview. Int J Pharm Pharm Sci 2015;7:1-9.

Antony A, Joel JJ, Shetty J, Umar NF. Identification and analysis of adverse drug reactions associated with cancer chemotherapy in hospitalized patients. Int J Pharm Pharm Sci 2016;8:448-51.

Hunger SP, Lu X, Devidas M, Camitta BM, Gaynon PS, Winick NJ, et al. Improved survival for children and adolescents with acute lymphoblastic leukemia from 1990-2005: A report from the Childrenâ€™s Oncology Group. J Clin Oncol 2012;30:1663-9.

Simanjorang C, Kodim N, Tehuteru E. Difference in survival of 5 years old patient with acute lymphoblastic leukemia and acute myeloblastic leukemia in Dharmais Cancer Hospital, Jakarta, 1997-2008. Indones J Cancer 2013;7:15-21

Azher U, Shiggaon N. Oral health status of children with acute lymphoblastic leukemia undergoing chemotherapy. Indian J Dent Res 2013;24:523.

Rimulo AL, Ferreira MC, Abreu MH, Aguirre-Neto JC, Paiva SM. Chemotherapy-induced oral mucositis in a patient with acute lymphoblastic leukaemia. Eur Arch Paediatr Dent 2011;12:124-7.

Ã‡ubukÃ§u Ã‡E, GÃ¼nes AM. Caries experience of leukemic children during intensive course of chemotherapy. J Clin Pediatr Dent 2007;32:155-8.

Thibodeau EA, Oâ€™Sullivan DM. Salivary mutans streptococci and caries development in the primary and mixed dentitions of children. Community Dent Oral Epidemiol 1999;27:406-12.

Thenisch NL, Bachmann LM, Imfeld T, Leisebach Minder T, Steurer J. Are mutans streptococci detected in preschool children a reliable predictive factor for dental caries risk? A systematic review. Caries Res 2006;40:366-74.

Widiaskara IM, Permono B, Ugrasena IDG, Ratwita M. Luaran pengobatan fase induksi pasien leukemia limfoblastik akut pada anak di Rumah Sakit Umum Dr. Soetomo Surabaya. Sari Pediatri 2010;12:128-34.

Hasle H. Pattern of malignant disorders in individuals with downâ€™s syndrome. Lancet Oncol 2001;2:429-36.

Eden T. Aetiology of childhood leukaemia. Cancer Treat Rev 2010;36:286-97.

Buffler PA, Kwan ML, Reynolds P, Urayama KY. Environmental and genetic risk factors for childhood leukemia: Appraising the evidence. Cancer Invest 2005;23:60-75.

Donadieu J, Auclerc MF, Baruchel A, Leblanc T, Landman-Parker J, Perel Y, et al. Critical study of prognostic factors in childhood acute lymphoblastic leukaemia: Differences in outcome are poorly explained by the most significant prognostic variables. Fralle group. Frech acute lymphoblastic leukemia study group. Br J Haematol 1998;102:729-39.

Windiastuti E. Childhood acute leukemia: Cipto Mangunkusumo Hospital experiences. Medan: Presented in Perhimpunan Hematologi dan Transfusi Darah Indonesia; 2011.

Yeoh AE, Tan D, Li CK, Hori H, Tse E, Pui CH. Management of adult and paediatric acute lymphoblastic leukaemia in Asia: Resource-stratified guidelines from the Asian Oncology Summit 2013. Lancet Oncol 2013;14:508-23.

Cooper SL, Brown PA. Treatment of pediatric acute lymphoblastic leukemia. Pediatr Clin North Am 2015;62:61-73.

Cortes JE, Kantarjian HM. Acute lymphoblastic leukemia. A comprehensive review with emphasis on biology and therapy. Cancer 1995;76:2393-417.

Pui CH, Evans WE. Acute lymphoblastic leukemia. N Engl J Med 1998;339:605-15.

Zhang XL, Komada Y, Chipeta J, Li QS, Inaba H, Azuma E, et al. Intracellular cytokine profile of T cells from children with acute lymphoblastic leukemia. Cancer Immunol Immunother 2000;49:165-72.