CYTOTOXICITY ACTIVITY OF PICRIA FEL-TERRAE LOUR. HERBS AGAINST 4T1 AND MCF-7 BREAST CANCER CELLS

Authors

  • Urip Harahap Department of Pharmacology, Faculty of Pharmacy, University of Sumatera Utara, Indonesia.
  • Poppy Anjelisa Zaitun Hasibuan Department of Pharmacology, Faculty of Pharmacy, University of Sumatera Utara, Indonesia.
  • Panal Sitorus Department of Pharmaceutical Biology, Faculty of Pharmacy, University of Sumatera Utara, Indonesia.
  • Denny Satria Department of Pharmaceutical Biology, Faculty of Pharmacy, University of Sumatera Utara, Indonesia.

DOI:

https://doi.org/10.22159/ajpcr.2018.v11s1.26608

Keywords:

Cytotoxicity, Picria fel-terrae Lour, Herbs, Fractions, Cell lines

Abstract

 Objective: This study was carried out to investigate the cytotoxic activity toward 4T1 and MCF-7 cell lines of Picria fel-terrae Lour. herb fractions.

Methods: P. fel-terrae Lour. herb powder was extracted by maceration method with n-hexane, ethyl acetate, and ethanol solvent. In vitro study was using MTT method toward 4T1 and MCF-7 cell lines.

Results: The inhibitory concentration 50% was 234.10 ± 7.85, 50.49 ± 1.07, and 212.53 ± 7.55 μg/mL for 4T1 and 84.62 ± 1.44, 56.79 ± 0.22, and 235.51 ± 4.77 μg/mL for MCF-7 cell lines, respectively.

Conclusion: The results reveal that P. fel-terrae Lour. herb fractions provide effective as anticancer. Our further study is to assess the mechanism of ethyl acetate fraction in inhibit angiogenesis and metastatic in breast cancer.

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Published

26-04-2018

How to Cite

Harahap, U., P. A. Z. Hasibuan, P. Sitorus, and D. Satria. “CYTOTOXICITY ACTIVITY OF PICRIA FEL-TERRAE LOUR. HERBS AGAINST 4T1 AND MCF-7 BREAST CANCER CELLS”. Asian Journal of Pharmaceutical and Clinical Research, vol. 11, no. 13, Apr. 2018, pp. 194-5, doi:10.22159/ajpcr.2018.v11s1.26608.

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