PHYTOCHEMICAL SCREENING AND ANTI-INFLAMMATORY ACTIVITY OF FRACTIONS FROM SAMBUNG RAMBAT (MICANIA CORDATA) LEAF

Authors

  • Zola Efa Harnis Department of Biological Pharmacy, Faculty of Pharmacy, University of Sumatera Utara, Medan, Indonesia.
  • Panal Sitorus Department of Biological Pharmacy, Faculty of Pharmacy, University of Sumatera Utara, Medan, Indonesia.
  • Rosidah Rosidah Department of Pharmacology, Faculty of Pharmacy, University of Sumatera Utara, Medan, Indonesia.

DOI:

https://doi.org/10.22159/ajpcr.2018.v11i8.26083

Keywords:

Anti-inflammatory, Carrageenan, Micania cordata, Phytochemical, Screening

Abstract

Objective: The present study is to evaluate the anti-inflammatory activity of various fractions from Sambung Rambat leaf (Micania cordata) using ethyl acetate, hexane, and water solvent as the solvent.

Methods: Investigation of phytochemical compound was using standard phytochemical screening method, while the anti-inflammatory was using the carrageenan-induced paw edema method in animal (rats) model.

Results: The phytochemical screening showed that the fractions of M. cordata had a lot of phytochemical compounds such as flavonoids, glycosides, steroids, triterpenoids, tannins, and saponins. Anti-inflammatory assessment showed that the strongest activity of anti-inflammatory produced by ethyl acetate fraction with 200 mg/kg BW dose.

Conclusion: This investigation could be concluded that ethyl acetate fraction of M. cordata might be a potential for the treatment of inflammatory.

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Author Biographies

Zola Efa Harnis, Department of Biological Pharmacy, Faculty of Pharmacy, University of Sumatera Utara, Medan, Indonesia.

Department of Biological Pharmacy

Panal Sitorus, Department of Biological Pharmacy, Faculty of Pharmacy, University of Sumatera Utara, Medan, Indonesia.

Department of Biological Pharmacy

Rosidah Rosidah, Department of Pharmacology, Faculty of Pharmacy, University of Sumatera Utara, Medan, Indonesia.

Department of Pharmacology

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Published

07-08-2018

How to Cite

Harnis, Z. E., P. Sitorus, and R. Rosidah. “PHYTOCHEMICAL SCREENING AND ANTI-INFLAMMATORY ACTIVITY OF FRACTIONS FROM SAMBUNG RAMBAT (MICANIA CORDATA) LEAF”. Asian Journal of Pharmaceutical and Clinical Research, vol. 11, no. 8, Aug. 2018, pp. 199-01, doi:10.22159/ajpcr.2018.v11i8.26083.

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