NEPHROPROTECTIVE ACTIVITY OF ETHANOL EXTRACT ROOT OF COGON GRASS (IMPERATA CYLINDRICA L. (BEAUV.)) ON CREATININE, UREA LEVELS, AND HEMATOLOGY PROFILE AGAINST GENTAMYCIN-INDUCED RENAL TOXICITY IN RATS

Abstract

 Objective: This study aimed to evaluate the effect of ethanol extract root of cogon grass on parameter creatinine, urea levels, and hematology profile in rats induced by gentamicin.

Methods: Thirty rats were divided into 6 groups of normal group (without treatment), groups of treatment only fed and watered, given carboxymethylcellulose (CMC) 0.5%, ethanol extract of the roots of cogon grass with each dose of 100, 200, and 400 mg/kg BW. Each group was given the test preparation orally for 8 days. After 1 h, 5 groups were induced by gentamicin at a dose 100 mg/kg bw intraperitoneally during 8 days. On the 9th day, blood samples were collected for serum creatinine, urea levels, and hematological parameters; hemoglobin (Hb), red blood cell, and packed cell volume.

Results: Ethanol extract root of cogon grass doses of 100 mg/kg bw, 200 mg/kg bw, and 400 mg/kg BW significantly decreased serum creatinine and urea levels, significantly increased hematological parameters as compared to negative control group of CMC 0.5% and negative control group not given CMC 0.5% (p<0.05). Ethanol extract root of cogon grass at a dose of 400 mg/kg bw showed there were not differences of creatinine, urea levels, and profile of hematology compared with normal group (p>0.05).

Conclusion: The ethanol extract root of cogon grass at a dose of 400 mg/kg bw was effective to ameliorate creatinine, urea levels, and hematological parameters.