COMPARISON OF INSULIN RESISTANCE WITH THE SEVERITY OF METABOLIC SYNDROME: Insulin resistance

BHAGYASHREE N; RAMASWAMY C; RAMYA K; GANESH M

doi:10.22159/ajpcr.2020.v13i9.38444

Authors

BHAGYASHREE N Department of Physiology, ACS Medical College and Hospital, Chennai, Tamil Nadu, India.
RAMASWAMY C Department of Physiology, Saveetha Medical College and Hospital, Chennai, Tamil Nadu, India.
RAMYA K Department of Physiology, ACS Medical College and Hospital, Chennai, Tamil Nadu, India.
GANESH M

DOI:

https://doi.org/10.22159/ajpcr.2020.v13i9.38444

Keywords:

Cardiovascular disease, Insulin resistance, Metabolic syndrome

Abstract

Objective: Insulin resistance (IR) means a reduced ability of insulin to stimulate glucose utilization. IR is related to cardiovascular disease (CVD) risk as the IR forms the basis for atherogenesis and acts as a major risk factor for atherosclerotic CVD.

Methods: Total of 195 participants were recruited divided into three groups based on the presence of metabolic abnormalities as control Group I (with <3 components of metabolic syndrome [MS]), MS group as Group II (with any 3 components of MS), and severe MS as Group III (with more than three components of MS).

Results: Results showed that fasting blood sugar (FBS) and glycated hemoglobin showed a significant difference between the groups (p<0.001), whereas fasting insulin and IR were higher in severe MS which showed statistically significant difference (p<0.001) in comparison with control and MS group.

Conclusion: IR is one of the principal factors for the development of MS and further threw light that the increase in the IR level proportionately increases the severity of MS.

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