IMPACT OF CHRONIC NOISE ON HIPPOCAMPAL MORPHOLOGY AND ITS FUNCTIONS IN WISTAR ALBINO RATS

ARCHANA ARJUNAN; RAVINDRAN RAJAN

doi:10.22159/ajpcr.2021.v14i7.39944

Authors

ARCHANA ARJUNAN Department of Physiology, Dr. Arcot Lakshmanaswami Mudaliar Post Graduate Institute of Basic Medical Sciences, University of Madras, Chennai, Tamil Nadu, India.
RAVINDRAN RAJAN Department of Physiology, Dr. Arcot Lakshmanaswami Mudaliar Post Graduate Institute of Basic Medical Sciences, University of Madras, Chennai, Tamil Nadu, India.

DOI:

https://doi.org/10.22159/ajpcr.2021.v14i7.39944

Keywords:

Anxiety, Fear, Hippocampus, Lateral ventricle, Noise, Obsessive-compulsive, Stress

Abstract

Objective: The study aims to investigate the effect of chronic noise stress on hippocampal morphology and its functions in male Wistar albino rats.

Methods: Adult albino rats were randomly divided into two groups. Each group contained six animals. Rats exposed to chronic noise stress (100 dB/4 h–30 days) were compared with control animal and assessed for behavior using hole-board test, marble burying test, and morphology of hippocampus by histology.

Results: The rats exposed to chronic noise stress showed significance (P < 0.05) of behavioral alterations such as increased fear and anxiety, obsessive-compulsive behavior, enlarged lateral ventricle, and reduced hippocampal volume.

Conclusion: The results reported that chronic noise stress affects neurobehavioral due to reduced hippocampal volume.

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