THE CONCEPT AND MANAGEMENT OF WAJAUL MAFASIL IN UNANI MEDICINE
DOI:
https://doi.org/10.22159/ajpcr.2021.v14i12.42218Keywords:
Wajaul Mafasil, Arthralgia, Osteoarthritis, Unani MedicineAbstract
More than 54 million Americans suffer from some form of arthritis and 23.7 million are limited in their usual activity, primarily due to pain. The study aims to highlight the concept of Arthralgia and the potential of its management in Unani Medicines. Osteoarthritis (OA) is a slowly progressive condition with a variable prognosis. In general, predicting the prognosis in patients with OA is difficult. However, pharmacological therapy can be associated with serious side effects and high costs. Therefore, alternative therapies have been under investigation. Herbal medications have shown the potential for safe and effective management of arthritis. The Unani Medicine is a rich source of classical knowledge on arthritis. OA has been mentioned as Wajaul Mafasil Balghami/Saudawi, and Unani Physicians has been treating this disease successfully with mostly single herbal drugs and their compound formulations for centuries. It has been revealed through animal, in vitro, and clinical studies that most of the single and compound Unani formulations are safe, without any side effects, and effective in OA, especially gout and rheumatoid arthritis. There is a need to conduct studies at Phase III level after analyzing 2nd Phase clinical studies of Unani medicine, so a promising safe, economic, and effective treatment can be provided to the ailing society for OA.
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Available from: https://www.who.int/medicines/areas/priority_ medicines/ch6_12osteo.pdf [Last accessed on 2021 Jul 01].
Cui A, Li H, Wang D, Zhong J, Cheng Y, Lu H, et al. Global, regional prevalence, incidence and risk factors of knee osteoarthritis in population-based studies. EClinicalMedicine 2020;29-30:100587.
Arthritis by the Numbers. Arthritis Foundation; 2019. Available from: https://www.arthritis.org/getmedia/e1256607-fa87-4593-aa8a- 8db4f291072a/2019-abtn-final-march-2019.pdf
Bala K, Bavoria S, Sahni B, Bhagat P, Langeh S, Sobti S, et al. Prevalence, risk factors, and health-seeking behavior for knee osteoarthritis among adult population in rural Jammu-a community-based cross-sectional study. J Family Med Prim Care 2020;9:5282-7.
Hafez AR. Knee osteoarthritis: A review of literature. Phys Med Rehabil Int 2014;1:8.
Osani MC, Vaysbrot EE, Zhou M, McAlindon TE, Bannuru RR. Duration of symptom relief and early trajectory of adverse events for oral nonsteroidal antiinflammatory drugs in knee osteoarthritis: A systematic review and meta-analysis. Arthritis Care Res (Hoboken) 2020;72:641-51.
Kolasinski SL, Neogi T, Hochberg MC, Oatis C, Guyatt G, Block J, et al. ACR/AF guideline for management of hand, hip, and knee OA. Arthritis Care Res 2020;72:149-62.
Curtis E, Fuggle N, Shaw S, Spooner L, Ntani G, Parsons C, et al. Safety of cyclooxygenase-2 inhibitors in osteoarthritis: Outcomes of a systematic review and meta-analysis. Drugs Aging 2019;36 Suppl 1:25-44.
Chan FK, Ching JY, Tse YK, Lam K, Wong GL, Ng SC, et al. Gastrointestinal safety of celecoxib versus naproxen in patients with cardiothrombotic diseases and arthritis after upper gastrointestinal bleeding (CONCERN): An industry-independent, double-blind, double-dummy, randomized trial. Lancet 2017;389:2375-82.
Testa G, Giardina SM, Culmone A, Vescio A, Turchetta M, Cannavò S, et al. Intra-articular injections in knee osteoarthritis: A review of literature. J Funct Morphol Kinesiol 2021;6:15.
Bannuru RR, Natov NS, Dasi UR, Schmid CH, McAlindon TE. Therapeutic trajectory following intra-articular hyaluronic acid injection in knee osteoarthritis-meta analysis. Osteoarthritis Cartilage 2011;19:611-9.
Jerosch J. Effects of glucosamine and chondroitin sulfate on cartilage metabolism in OA: Outlook on other nutrient partners especially omega-3 fatty acids. Int J Rheumatol 2011;3:969012.
Henrotin Y, Mobasheri A, Marty M. Is there any scientific evidence for the use of glucosamine in the management of human osteoarthritis? Arthritis Res Ther 2012;14:201.
Dostrovsky NR, Towheed TE, Hudson RW, Anastassiades TP. The effect of glucosamine on glucose metabolism in humans: A systematic review of the literature. Osteoarthritis Cartilage 2011;4:375-80.
Long L, Soeken K, Ernst E. Herbal medicines for treatment of osteoarthritis-a systemic Review. Rheumatology (Oxford) 2001;40:779-93.
Soeken KL, Miller SA, Ernst E. Herbal medicines for the treatment of rheumatoid arthritis: A systematic review. Rheumatology (Oxford) 2003;42:652-9.
Usaiba IA. Al Uyoon ul Anba Fee Tabaqat-il Attiba, Urdu Edition, (1203-1270). Vol. 1. New Delhi: CCRUM; 1990. p. 84, 585, 605-6.
Nigrami HS. Tareekhe Tib. New Delhi: Urdu Taraqqi Beauru; 1989. p. 137.
Qadeer A. Tarikhe Tib WA Akhlaqiyat. 3rd ed. New Delhi: Ghaffar Manzil; 2005. p. 155-577, 149-52, 164-6.
Sheikh BAIS (980-1037AD). Alqanoon Fittib. Urdu Edition Ghulam Husain Kantoori. Vol. 3. Lucknow: Munshi Nawal Kishore; 1930. p. 180-7.
Arzani MA. Tibbe Akbar. Lucknow: Matba Munshi Nawal Kishore; 1890. p. 617-28.
Kabiruddin M. Moalejat: Sharah Asbab (Tarjuma Kabir). Vol. 3. Hyderabad: Hikmat Book Depo; 1916. p. 213-30.
Najibuddin S. Moalejat: Sharah Asbab. Commentary by Ibne Nafees (Tarjuma Kabir), (1222AD). Vol. 3. Hyderabad: Hikmat Book Depo; 1916. p. 189-1952.
Alaksir KA. Urdu Edn Hakim Kabiruddin, (1813-1902AD). Vol. 2. New Delhi, Daryaganj: Aijaz Publishing House; 2003. p. 1425-8, 430-56.
Razi AM. Kitabul Hawi, Urdu Edition. (865-925). Vol. 11. New Delhi: CCRUM; 2002. p. 100-1, 106, 111-12, 120, 124, 174, 182.
Nafees I. Moajazal Qanoon, Urdu Edition Kausar Chandpuri, (686AD). New Delhi: Taraqqi Urdu Beauru, GOI; 1998. p. 401-8.
Jurjani AH. Zakhira Khwarizm Shahi, Urdu Edition Hkm, Hadi Hasan, (1878 AD). Vol. 4. Lucknow: Matba Munshi Nawal Kishore; 1878. p. 637-48.
Razi AM. Kitabul Mansoori, Urdu Edition, (865-925). New Delhi: CCRUM; 1991. p. 391-4.
Baghdadi IH. Kitabul Mukhtarat fil Tib. Vol. 4. Hyderabad: Dairatul Maarif; 1364. p. 84-90.
Majusi AH. Kamil us Sana, Urdu Edition Ghulam Husain Kantoori, (930-994AD). Lucknow: Matba Nawal Kishore; 1989. p. 507-14.
Arzani MA. Meezanul Tib. New Delhi: Taraqqi Urdu Beauru; 1992. p. 83-5.
Tabari AH. Firdaus Ul Hikmat. Urdu Edition Hkm. M. Awwal Shah Sanbhali, (780-850 AD). New Delhi, Daryaganj: Idara Kitabul Shifa; 2009. p. 291-3.
Azmi WA. Moalejat, Vol. 3. New Delhi: Taraqqi Urdu Beauru, GOI; 1992. p. 132-5.
Kabiruddin M. Biyaze Kabir. Vol. 2. Hyderabad: Hikmat Book Depo; 1938. p. 229-36.
Kabiruddin M. Takmila Kitabul Advia. Hyderabad: Hikmat Book Depo; 1930. p. 12-3, 16-7,100-1.
Hakeem A. Bustanul Mufredat, (13011H). New Delhi: Zafar Book Depo; 1893. p. 56, 62, 81, 208, 280.
Ali SS. Unani Adviyae Mufreda. New Delhi: Taraqqi Urdu Beauru, GOI; 1993. p. 33, 42, 61, 83,191-92, 241.
Kabiruddin M. Biyaze Kabir Part-III. Hyderabad: Hikmat Book Depo; 1938. p. 25, 35, 40, 63-7, 69, 87,126, 129-30,135-37, 139.
Anonymous. National Formulary of Unani Medicine, Urdu Edition. Vol. 1. New Delhi: Ministry of Ayush, GOI; 1983. p. 198, 201-4, 210- 36,290-308.
Siddiqui MZ, Ahmad G, Amin KM, Akhtar S, Rehman A. HPLC profiling conclusively distinguished two important Unani drugs, namely, Suranjan Shirin (Colchicum autumnale) and Suranjan Talkh (Colchicum luteum). Indian J Tradit Knowl 2020;19:170-3.
Javed M, Khan JA, Siddiqui MM. Effect of Colchicum luteum baker in the management of rheumatoid arthritis. Indian J Tradit Knowl 2005;4:421-3.
Srivastava JK, Shankar E, Gupta S. Chamomile: A herbal medicine of the past with bright future. Mol Med Rep 2010;3:895-901.
Saeed P, Mahboob S, Sanayei M, Hajaliloo M, Safaeiyan A. The effect of chamomile tea consumption on inflammation among rheumatoid arthritis patients: Randomized clinical trial. Prog Nutr 2017;19 Suppl 1:27-33.
Lindler BN, Long KE, Taylor NA, Lei W. Use of herbal medications for treatment of osteoarthritis and rheumatoid arthritis. Medicines (Basel) 2020;7:67.
Osama M, Ikram R. Aqua distillation enhances the analgesic and anti-inflammatory properties of Rosa damascena mill; a pilot study. Int J Pharm Sci Res 2018;9:5344-9.
Singh D, Aggarwal A, Maurya R, Naik S. Withania somnifera inhibits NF-κB and AP-1 transcription factors in human peripheral blood and synovial fluid mononuclear cells. Phytother Res 2007;21:905-13.
Sumantran VN, Kulkarni A, Boddul S, Chinchwade T, Koppikar SJ, Harsulkar A, et al. Chondroprotective potential of root extracts of Withania somnifera in osteoarthritis. J Biosci 2007;32:299-307.
Ramakanth GS, Kumar CU, Kishan PV, Usharani P. A randomized, double-blind, placebo-controlled study of efficacy and tolerability of Withaina somnifera extracts in knee joint pain. J Ayurveda Integr Med 2016;7:151-7.
Alipour Z, Asadizaker M, Fayazi S, Yegane N, Kochak M, Zadeh MH. The effect of ginger on pain and satisfaction of patients with knee osteoarthritis. Jundishapur J Chronic Dis Care 2017;6:e34798.
Amorndoljai P, Taneepanichskul S, Niempoog S, Nimmannit U. A comparative of ginger extract in nanostructure lipid carrier (NLC) and 1% diclofenac gel for treatment of knee osteoarthritis (OA). J Med Assoc Thai 2017;100:447-56.
Therkleson T. Topical ginger treatment with a compress or patch for osteoarthritis symptoms. J Holist Nurs 2014;32:173-82.
Singh S, Nair V, Gupta YK. Antiarthritic activity of majoon suranjan (a polyherbal Unani formulation) in rat. Indian J Med Res 2011;134:384-8.
Subramaneyaan M, Yasmeen S, Ahmed RS, Arora VK, Tripathi AK, Banerjee BD. Evaluation of therapeutic efficacy of Majoon Suranjan, a Unani formulation, in the treatment of rheumatoid arthritis: An experimental study. Exp Biol Med (Maywood) 2013;238:1379-87.
Ghazanfar K, Dar SA, Nazir T, Akbar S. Subchronic oral toxicity study of Habb-e-Suranjan in albino Wistar rats. J Complement Integr Med 2018;15: DOI: 10.1515/jcim-2017-0144.
Ahmed NZ, Ahmad K, Ezhil R, Anjum N, Khan AA. Evaluation of analgesic effect of unani pharmacopoeial formulation Habb-E-Suranjan and Raughan-E-Suranjan in Wajaul Mafasil (joints pain) patients: An open prospective clinical trial. JDDT 2021;11:44-9.
Ahmad S, Mohiuddin E, Shah SM, Akram M, Amjad M, Nisar J, Riaz M, et al. Therapeutic efficacy of urinile against gouty arthritis. Dose Response 2020;18:DOI: https://doi.org/10.1177/1559325820946934.
Khan P, Bano H, Verma RS, Rehman S, Ayub S, Devi MK, et al. Efficacy and safety of unani drugs to combat chronic gout-a preliminary study. Int J Recent Sci Res 2021;12:41723-8.
Iqbal A, Quraishi HA, Rashid A, Raheem A. Evaluation of a unani formulation in the treatment of osteoarthritis and its antioxidant activity. Res J Life Sci Bioinform Pharm Chem Sci 2019;5:611-31.
Nayab M, Anwar M, Qamri A. Clinical study on Wajaul Mafasil and evaluation of efficacy of Hijama Bila Shurt in the treatment. Indian J Tradit Knowl 2011;10:697-701.
Shamim A, Idris M. Comparative study for cumulative drug release of Unani Emulgel dosage form with Raughan: A novel approach. Pharma Innov J 2019;8:389-98.
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