CT EVALUATION FOR THE EFFICACY OF A UNANI FORMULATION WITH INKEBAB IN THE TREATMENT OF ILTEHAB TAJAWEEFE ANAF MUZMIN

ZEHRA ZAIDI; ABHINAV JAIN; ASIM ALI KHAN

doi:10.22159/ajpcr.2024.v17i2.47465

Authors

ZEHRA ZAIDI Department of Ain, Uzn, Anaf, Halaq WA Asnan, SUMER, Jamia Hamdard, New Delhi, India. https://orcid.org/0000-0002-1021-1202
ABHINAV JAIN Department of Radio-Diagnosis, HIMSR, Jamia Hamdard, New Delhi, India.
ASIM ALI KHAN Department of Moalejat, SUMER, Jamia Hamdard, New Delhi, India.

DOI:

https://doi.org/10.22159/ajpcr.2024.v17i2.47465

Keywords:

Chronic rhinosinusitis, Unani formulation, Katan, Kalonji, Inhalation, Computed tomography paranasal sinuses

Abstract

Objective: To establish the efficacy of the oral Unani formulations with inhalation of Kalonji in comparison with the standard control in Iltehab Tajaweefe Anaf Muzmin (Chronic Rhinosinusitis [CRS]) based on the computed tomography (CT) paranasal sinuses (PNS) findings. To provide safe, effective, and economical treatment for Iltehab Tajaweefe Anaf Muzmin.

Methods: In this randomized, single-blind, standard-controlled study of 45 patients with CRS, the patients were allocated to two groups. In Group A, patients received Unani oral formulation: Katan (Linum usitatissimum), Filfil siyah (Piper nigrum), and Asl-e-Khalis in a 6 g BD dose with steam inhalation of Kalonji (Nigella sativa) BD and Tab Alaspan 1OD with Karvol Plus inhalation BD in Group B. Statistical data was analyzed using a paired-t test by comparing the total sinus score (TSS) of CT PNS calculated based on the Lund Mackay staging system before and after treatment.

Results: The result is statistically significant in Group A in comparison to the non-significant effect in Group B (p<0.05). After treatment, there was a 30% complete resolution of the TSS in CT PNS imaging in group A, in comparison to the 0% complete resolution of the TSS in group B. No adverse effects were reported during the study.

Conclusion: The oral Unani formulation with inhalation of Kalonji is safe and has a statistically significant effect on TSS (CTPNS) in patients with CRS in Group A. A multicentric trial of the test drug on a larger sample size for a longer duration is required to establish the efficacy of the Inkebab of Kalonji with oral Unani formulation on patients with CRS.

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Author Biography

ZEHRA ZAIDI, Department of Ain, Uzn, Anaf, Halaq WA Asnan, SUMER, Jamia Hamdard, New Delhi, India.

Associate Professor & HOD Department of Ain, Uzn, Anaf, Halaq WA Asnan, SUMER, Jamia Hamdard, New Delhi

References

Albu S. Chronic rhinosinusitis-an update on epidemiology, pathogenesis and management. J Clin Med 2020;9:2285. doi: 10.3390/jcm9072285

Rudmik L, Smith TL, Schlosser RJ, Hwang PH, Mace JC, Soler ZM. Productivity cost in patients with refractory chronic rhinosinusitis. Laryngoscope 2014;124:2007-12.

Yeolkar AM, Dasgupta KS, Khode S, Joshi D, Gosrani N. A study of SNOT 22 scores in adults with no sinonasal disease. J Rhinolaryngootol 2013;1:6-10.

Kennedy DW, Kuhn FA, Hamilos DL, Zinreich SJ, Butler D, Warsi G, et al. Treatment of chronic rhinosinusitis with high-dose oral terbinafine: A double blind, placebo-controlled study. Laryngoscope 2005;115:1793-9.

Hopkins C, Slack R, Lund V, Brown P, Copley L, Brown J. The national comparative audit of surgery for nasal polyposis and chronic rhinosinusitis. Laryngoscope 2009;119:2459-65. doi: 10.1002/ lary.20653

Ghazi-Moghadam K, Inancli HM, Bazazy N, Plinkert PK, Efferth T, Sertel S. Phytomedicine in otorhinolaryngology and pulmonology: Clinical trials with herbal remedies. Pharmaceuticals (Basel) 2012;5:853-74. doi: 10.3390/ph5080853

Jurjani AH. 1878 AD. Zakhira Khwarizm Shahi, Vol. 2., Part VI, Urdu Edition by Hkm. Hadi Hasan Khan, Lucknow: Matba Munshi Nawal Kishore; 1903. p. 205-6.

Benninger MS, Ferguson BJ, Hadley JA, Hamilos DL, Jacobs M, Kennedy DW, et al. Adult chronic rhinosinusitis: Definitions, diagnosis, epidemiology and pathophysiology. Otolaryngol Head Neck Surg 2003;129:S1-32.

Naclerio RM. Xolair in Patients with Chronic Sinusitis. Chicago: US National Institute of Health, University of Chicago. Available from: https://clinicaltrials.gov Available from: https://clinicaltrials.gov/ct2/ show/NCT00117611 [Last accessed on 2015 Dec 05].

Kabiruddin M. Moalejat; Sharah Asbab. 9th ed., Vol. 1. Hyderabad: Hikmat Book Depo; 1980. p. 15-20.

Al-Jawad FH, Al-Razzuqi RA, Hashim HM, Ismael AH. Broncho- relaxant activity of Nigella sativa versus Anthemis nobilis in chronic bronchial asthma; a comparative study of efficacy. IOSR J Pharm 2012;2:81-3.

Ferrara L, Naviglio D, Caruso AA. Cytological aspects on the effects of a nasal spray consisting of standardized extract of Citrus lemon and essential oils in allergic rhinopathy. ISRN Pharm 2012;2012:404606.

Deepti NV, et al. Chronic rhinosinusitis-a overview. Amrita J Med 2012;8:4-9.

Hamdani SK. Usoole Tibb Lucknow: Uttar Pradesh Urdu Council; 1980. p. 18-22.

Kim HU, Kim SS, Park HJ, Yoon JH, Lee JG. Effect of hot steam inhalation on microcirculation of nasal mucosa. J Rhinol 2000;7:137-41.

Li J, Zheng C, Lin H, Yang C, Gu S, Wang Y, et al. Effect of Zhu- Yuan decoction in patients with chronic rhinosinusitis after functional endoscopic sinus surgery. J Tradit Chin Med 2018;38:83-8. doi: 10.1016/j.jtcm/2018.02.003

Bang JS, Oh DH, Choi HM, Sur BJ, Lim SJ, Kim JY, et al. Anti-inflammatory and antiarthritic effects of piperine in human Interleukin 1β-stimulated fibroblast-like synoviocytes and in rat arthritis models. Arthritis Res Ther 2009;11:R49. doi: 10.1186/ar2662

Pratibha N, Saxena VS, Amit A, D’Souza P, Bagchi M, Bagchi D. Anti-inflammatory activities of Aller-7, a novel polyherbal formulation for allergic rhinitis. Int J Tissue React 2004;26:43-51.

Hussein SZ, Yusoff KM, Makpol S, Yusof YA. Gelam honey attenuates Carrageenan-induced rat paw inflammation via NF-κB pathway. PLoS One 2013;8:e72365. doi: 10.1371/journal.pone.0072365

Elahi H, Masroorchehr MR, Nemati S, Kamalinejad M, Besharat M, Hajimehdipoor H, et al. Historical applications of Nigella sativa L. (Black cumin) in the treatment of Zokam and Nazleh in Persian Medicine. Res Hist Med 2014;3:11-20.

Nikakhlagh S, Rahim F, Aryani FH, Syahpoush A, Brougerdnya MG, Saki N. Herbal treatment of Allergic rhinitis: The use of Nigella sativa. Am J Otolaryngol 2011;32:402-7.

Alsamarai AM, Abdulsatar M, Alobaidi AH. Evaluation of topical black seed oil in the treatment of allergic rhinitis. Anti Inflamm Antiallergy Agents Med Chem 2014;13:75-82. doi: 10.2174/18715230113129990014

Boskabady MH, Vahedi N, Amery S, Khakzad MR. The effect of Nigella sativa alone, and in combination with dexamethasone, on tracheal muscle responsiveness and lung inflammation in sulphur mustard exposed guinea pigs. J Ethnopharmacol 2011;137:1028-34.

Atal N, Bedi KL. Bioenhancers: Revolutionary concept to market. J Ayurveda Integr Med 2010;1:96-9. doi: 10.4103/0975-9476.65073

Hakeem A. Bustanul Mufredat. New Delhi: Zafar Book Depo 1311 H;. p. 221.

Baiytar I. 1248. Aljame Almufredat Aladwiya Wal Aghziya. Urdu Edition., Vol. 3. New Delhi: CCRUM; 2003. p. 377-9.

Ghani NM. Khazaynul Adwiya. Vol. 1. Lahore, Pakistan: Sheikh Bashir & Sons; 1920. p. 560.

Kabiruddin M. Makhzanul Mufredat. Lahore, Pakistan: Sheikh Bashir & Sons; 1951. p. 86-7, 460-1.

Zaidi Z, Khan AA, Jabeen A. Single blind, randomised, control trial of A unani compound formulation in iltehab Tajaweefe Anaf Muzmin. Asian J Pharm Clin Res 2021;14:171-5. doi: 10.221595