A SINGLE-BLIND, PLACEBO-CONTROLLED CLINICAL TRIAL OF LOCAL APPLICATION OF KOHL-CHIKNI DAWA-A UNANI COMPOUND FORMULATION IN THE PATIENTS WITH CORNEAL OPACITY

ZEHRA ZAIDI; SHEHLA NAZIR

doi:10.22159/ajpcr.2022.v15i11.44717

Authors

ZEHRA ZAIDI Department of Ain, Uzn, Anaf, Halaq WA Asnan, School of Unani Medical Education and Research, Jamia Hamdard, New Delhi, India. https://orcid.org/0000-0002-1021-1202
SHEHLA NAZIR Department of Tashreeh WA Munafeul Aza, School of Unani Medical Education and Research, Jamia Hamdard, New Delhi, India.

DOI:

https://doi.org/10.22159/ajpcr.2022.v15i11.44717

Keywords:

Kohl-Chikni Dawa, Corneal opacity, Unani medicine, Nebular opacity

Abstract

Objective: The present clinical trial was undertaken to evaluate the safety, preventive/curative efficacy of the local application of Kohl-Chikni Dawa (KCD) in patients with corneal opacity (CO), to provide an economic, safe, and effective alternative treatment for it.

Methods: The present prospective single-blind, placebo-controlled trial was undertaken at Majeedia Hospital, Hamdard University, New Delhi. Ninety-two diagnosed patients of CO were randomly allocated to three groups for local application of KCD/placebo two sticks BID.

Results: Forty patients completed the 6-month duration of the study. KCD was found effective in the general amelioration of the signs and symptoms of CO. There was a statistically significant reduction in the CO score and improvement in vision on the reading of the Snellen chart in the test drug group in comparison to the placebo group in Grade-I (Nebular type) CO (p>0.05).

Conclusion: KCD was found very much effective to reduce the CO score, with clinical improvement of vision in the nebular type of CO. The dose of KCD in two sticks BID was found safe and tolerable with no side effects. A multicentric trial of the test drug on larger sample size for a longer duration is required to establish the efficacy of the formulation on CO.

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References

Vernon SA. Differential Diagnosis in Ophthalmology. London: Manson Publishing Limited; 1999. p. 173-8.

Dandona L, Naduvilath TJ, Janarthanan M, Ragu K, Rao GN. Survival analysis and visual outcome in a large series of corneal transplants in India. Br J Ophthalmol 1997;81:726-31. doi: 10.1136/bjo.81.9.726, PMID 9422922

Whitcher JP, Srinivasan M, Upadhyay MP. Corneal blindness: A global perspective. Bull World Health Organ 2001;79:214-21. PMID 11285665

Thylefors B, Négrel AD, Pararajasegaram R, Dadzie KY. Global data on blindness. Bull World Health Organ 1995;73:115-21. PMID 7704921

Gupta N, Tandon R, Gupta SK, Sreenivas V, Vashist P. Burden of corneal blindness in India. Indian J Community Med 2013;38:198-206. doi: 10.4103/0970-0218.120153, PMID 24302819

Oliva MS, Schottman T, Gulati M. Turning the tide of corneal blindness. Indian J Ophthalmol 2012;60:423-7. doi: 10.4103/0301-4738.100540, PMID 22944753

Barbara G .Green Pharmacy. A History of Herbal Medicine. Jill Noman and Hobhouse Ltd; London, 1981:313-36

Khan MS, Amraz I, Mujtabaee M, Delhi, 1903:75.

Kabiruddin M, Kabir B. Vol. 2. Hyderabad: Hikmat Book Depo; 1938. p. 111.

Miller SJ. Diseases of the Cornea, Pearsons’ Diseases of Eye. 18th ed. Melbourne, New York: Churchill Livingstone; 1990. p. 167-70.

Ministry of Health and Family Welfare GOI. Anonymous. National Formulary of India, Part-I, Department of Indian Medicine. New Delhi: Ministry of Health and Family Welfare GOI; 1981. p. 58-62.

Bayaz-e Kabir KM. Vol. 3. Hyderabad: Hikmat Book Depo; 1921. p. 37.

Ghosh MK, Mitra D, Banerjee AK, Roy IS. Clinical Evaluation of an Indigenous Herbal Eye Drops Preparation [Preliminary Report]. The Indian Practitioner. Vol. 38. 1985. p. 1149-53.

Mitra AK, Gupta AK, Debdas M. Clinical observations on an herbal eye drops preparation. Antiseptic 1986;567-69.

Sesaki K, Shibata T, Obazavz H, Fujiwara T, Kogure F, Obara Y, et al. Classification system of cataracts. Ophthalmic Res 1990;22:45-6.

Bayaz-e Kabir KM. Vol. 1. Hyderabad: Hikmat Book Depo; 1935. p. 44-5.

Bustanul Mufredat HA, Book Depo Z. New Delhi: 1893. p. 127-222.

Mufredat KM. Vol. 294,394. Lahore, Pakistan: Sheikh Bashir and Sons; 1951. p. 203.

Ali SS, Mufreda UA, Taraqqi Urdu Beauru GOI. New Delhi: Vol. 317; 1993.