• ASHISH SHARMA Department of Pharmacology, Chirayu Medical College and Hospital, Bhopal 462 030, Madhya Pradesh, India. https://orcid.org/0000-0001-8501-4345




Curcuma longa, Aqueous extract, Anxiolytic


Objectives: This study was performed to see the effects of aqueous extract of purified Curcuma longa (CL) on anxiety levels of Swiss albino mice using open-field test.

Methods: CL at 50 mg/kg body weight (b.w) (CL50), CL at 100 mg/kg b.w. (CL100), and CL at 200 mg/kg b.w. (CL200) with negative and positive controls were used. The experimental results were represented as mean±standard deviation, p<0.05 was considered. Statistical differences between the test drug and control groups as well as within the test drug groups were calculated using Mann–Whitney U-test.

Results: The number of squares crossed in 5 min was least in distilled water (DW) as compared to all other groups (CL50, CL100, and CL200 [p=0.002], diazepam [p=0.002]).Time spent in the central square was lesser in the DW group than CL50 (p=0.045), CL200 (p=0.005), and DP (p=0.004). More time was spent by DP in the central square than CL50 (p=0.045) and CL100 (p=0.037) groups. The number of rearing was lesser in DW group as compared to CL50 (p=0.030), CL100 (p=0.006), and CL 200 (p=0.006) as well as DP. The number of rearing was less in CL50 than CL200 (p=0.045) group.

Conclusion: This study showed that CL possesses anxiolytic effect.


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How to Cite

SHARMA, A. “EFFECTS OF AQUEOUS EXTRACT OF PURIFIED CURCUMA LONGA ON ANXIETY LEVELS IN SWISS ALBINO MICE”. Asian Journal of Pharmaceutical and Clinical Research, vol. 15, no. 8, Aug. 2022, pp. 179-83, doi:10.22159/ajpcr.2022.v15i8.44810.



Original Article(s)