EFFECTS OF AQUEOUS EXTRACT OF PURIFIED CURCUMA LONGA ON MOTOR PERFORMANCE IN MICE
Keywords:Curcuma longa, Aqueous extract, Motor performance
Objective: This study was performed to see the effects of aqueous extract of purified Curcuma longa (CL) on motor performance of albino mice using rota test.
Methods: CL at 50mg/kg body weight (b.w.) (CL50), CL at 100 mg/kg b.w. (CL100), and CL at 200 mg/kg b.w. (CL200) with negative and positive controls were used. The experimental results were represented as mean±2 standard deviation, p was set at < 0.05. Statistical differences between the test drug and control groups as well as within the test drug groups were calculated using Mann–Whitney U-test.
Results: As compared to CL200, DW (distilled water 10 ml/kg p.o.) group fall off time was significantly less (p=0.004). Diazepam (5 mg/kg i.p.) group stayed for lesser time on the rotating rod than CL50, CL100, and CL200 groups (p=0.004). Fall off time in CL100 group was significantly lesser than CL 200 group (p=0.019).
Conclusion: This study showed that CL possesses motor performance increasing effects at 200 mg.
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