STUDY OF THE ANTIDEPRESSANT ACTIVITY OF THE ETHANOLIC EXTRACT OF THE LEAVES OF MORINGA OLEIFERA L. (EEMO) ON ALBINO MICE

SHIPRA KAUSHIK; SHOBHIT KAUSHIK; JAYANT RAI

doi:10.22159/ajpcr.2023.v16i2.46291

Authors

SHIPRA KAUSHIK Department of Pharmacology, GS Medical College and Hospital, Pilkhuwa, Hapur, India.
SHOBHIT KAUSHIK Department of Anaesthesiology, GS Medical College and Hospital, Pilkhuwa, Hapur, India.
JAYANT RAI Department of Anaesthesiology, GS Medical College and Hospital, Pilkhuwa, Hapur, India.

DOI:

https://doi.org/10.22159/ajpcr.2023.v16i2.46291

Keywords:

anti-depressant, forced swimming test, tail suspension test, Moringa oleifera

Abstract

Objectives: The aim of the study is to evaluate the antidepressant activity of the ethanolic extract of the leaves of Moringa oleifera L. (EEMO) on albino mice.

Methods: The anti-depressant activity was evaluated using forced swimming test (FST) and tail suspension test (TST). Healthy albino mice were individually forced to swim inside a vertical glass cylinder. Climbing, swimming, and immobility were tested and recorded. In TST, mice were suspended on a string held by a metal stand, and immobility time was recorded.

Results: In both FST and TST, it was seen that immobility time decreased with increase in the dose of EEMO.

Conclusion: Ethanolic extract of M. oleifera possess anti-depressant activity in a dose dependent manner.

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References

Martínez AA. A way of bridging the gap between psychological treatments and antidepressant medication. Int J Depress Anxiety 2019;2:10. doi: 10.23937/IJDA-2017/1710010

Koirala B, Rauniar G, Shakya D. Adverse effects including sexual problems associated with the use of selective serotonin reuptake inhibitors in a tertiary care center of Eastern Nepal. Int J Basic Clin Pharmacol 2015;4:651-6. doi: 10.18203/2319-2003.ijbcp20150366

World Health Organization. Depression and other Common Mental Disorders: Global Health Estimates. Geneva: World Health Organization; 2017.

World Health Organization. Preventing Suicide: A Global Imperative. Geneva: World Health Organization; 2014.

Harichandran DT, Viswanathan MT, Gangadhar R. Adverse drug reactions among hospitalized patients in psychiatry department in a tertiary care hospital. J Health Res Rev 2016;3:77-80. doi: 10.4103/2394-2010.184243

Kushwaha V, Agrawal P, Singh S, Chaudhary D, Verma AK, Sharma H. assessment of adverse drug reactions of antidepressant drugs used in psychiatry department of a tertiary care hospital. Asian J Pharm Clin Res 2022;15:49-54. doi: 10.22159/ajpcr.2022.v15i4.44287

Fatima N, Fatima SJ. Pharmacological screening for antiarthritic activity of Moringa oleifera. Asian J Pharm Clin Res 2016;9:106-11.

Jahagirdar AQ, Hugar S, Patil VP, Khot AK, Nanjappaiah HM. Screening of antistress activity of Ficus benghalensis fruit extract. Res J Pharm Technol 2020;13:191-6. doi: 10.5958/0974- 360X.2020.00039.6

Malik J, Karan M, Dogra R. Ameliorating effect of Celastrus paniculatus standardized extract and its fractions on 3-nitropropionic acid induced neuronal damage in rats: Possible antioxidant mechanism. Pharm Biol 2017;55:980-90. doi: 10.1080/13880209.2017.1285945, PMID 28164735

OECD Guidelines for Testing of Chemicals. Health Effects: Test No. 425: Acute Oral Tocicity: Up and down Procedure. France: OECD Publishing; 2006. Available from: http;//www.oecdbookshop.org/oecd/ index [Last accessed on 2008 Sep 27].

Porsolt RD, Bertin A, Jalfre M. Behavioural despair in rats and mice: Strain differences and the effects of imipramine. Eur J Pharmacol 1978; 51:291-4.

Kanase V, Shaikh S. Evaluation of antistress activity of ethanolic extract of Chromolaena odorata leaves in albino Wistar rats. Asian J Pharm Clin Res 2019;12:50-5.

Singh S, Upadhyay A, Sirbaiya AK. Neuropharmacological screening, anti-stress activity, and toxicity studies of standardized extract of the seeds of Celastrus paniculatus willd. Asian J Pharm Clin Res 2021;14:52-6. doi: 10.22159/ajpcr.2021.v14i11.42557

Nanjappaiah HM, Patil VP, Muchchandil S, Chandrashekar VM, Shivakumar H. Screening of antistress and anxiolytic activities of Piper longum fruits extract. J Pharm Biosci 2017;5:1-11.

Lotankar RA, Wankhede S, Sharma JB, Momin JA. Antistress activity of flavonoids rutin and quercetin isolated from the leaves of Ficus benghalensis. Int J Pharm Pharm Res 2016;5:5-19.