EXPLORING LIPID VARIATIONS IN UMBILICAL CORD BLOOD ACROSS DIFFERENT DELIVERY MODES

Authors

  • AVINASH NAMDEO JADHAO Department of Biochemistry, Seth GSMC and KEMH, Mumbai, Maharashtra, India.
  • TRUPTI DIWAN RAMTEKE Department of Biochemistry, Government Medical College and Hospital, Nandurbar, Maharashtra, India.
  • AMIT RAMESH BARAPATRE Department of Biochemistry, TNMC and BYL Nair Charitable Hospital, Mumbai, Maharashtra, India.

DOI:

https://doi.org/10.22159/ajpcr.2024.v17i3.50533

Keywords:

umbilical cord blood, lipid profile, delivery modes

Abstract

Objective: The mode of delivery (vaginal or cesarean) may affect the lipid profile of the newborn, which has implications for their future health.

Methods: The study included 150 mothers who gave birth vaginally and 50 mothers who underwent elective cesarean sections. All mothers were aged between 21 and 44 years. The main outcome measures were the serum lipid levels of umbilical cord blood of newborns. The lipid levels included total cholesterol (TC), triglycerides, high-density lipoprotein cholesterol, very low-density lipoprotein (VLDL-D), and low-density lipoprotein (LDL-C). The study compared the obstetric variables and the serum lipid levels between the two groups of mothers.

Results: The two groups did not differ significantly in terms of maternal age, neonatal weight, gestational duration, placental weight, and neonatal gender distribution. The newborns delivered by normal vaginal delivery had higher levels of total cholesterol, triglycerides, high-density lipoprotein cholesterol, VLDL-D, and LDL-C than those delivered by cesarean section, but the difference was not statistically significant.

Conclusions: This study suggests that the mode of delivery does not have a significant impact on umbilical cord serum lipid levels. However, the sample size was small, and the results may not be generalizable to other populations.

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References

Fuentes RM, Notkola IL, Shemeikka S, et al. Tracking of serum total cholesterol during childhood: an 8-year follow-up population-based family study in eastern Finland. Acta Paediatr, 2003; 92:420–424. 2.Bastida S, Sanchez-Muniz FJ, Cuena R, et al. High density lipoprotein-cholesterol changes in children with high cholesterol levels at birth. Eur J Pediatr, 2002; 161:94–98

Bansal, Narinder; Cruickshank, J Kennedy; McElduff, Patrick; et al. Cord blood lipoproteins and prenatal influences. Current opinion in lipidology, 2005:1, 400–408 .

Nobuyuki Y ,Tsutomu D ,Hideki Y ,Yukihiro N ,Tetsuo A.Differences in umbilical cord serum lipid levels with mode of delivery.British Journal of Obstetrics and Gynaecology ,1999;106 :144- 147

Hanning RV, Barrett DA, Alberino SP, Lynski MT, Donabedian R, Speroff L. Interrelationships between maternal and cord prolactin, progesterone, estradiol, 13, 14-dihydro- 15-keto-prostaglandin F2 alpha, and cord cortisol at delivery with respect to initiation of parturi tion.Am Jobstet Gynecol1978; 130 204-210.

Ose L, Iden A, Bakke T, Aarskog D. Neonatal screening for hyperlipi daemia. Postgrad Med J 1975; 51 [Suppl8]: 88-92

Blackburn ST. Maternal, fetal, and neonatal physiology: a clinical perspective. 2nd ed. St Louis: Saunders; 2003.

Herrera E. Implications of dietary fatty acids during pregnancy on placental,fetal and postnatal development :a review.Placenta, 2002; 23[Suppl A]:S9–S19.

Lane DM, McConathy WJ. Factors affecting the lipid and apolipoprotein levels of cord sera. Pediatr Res, 1983; 17:83–91.

Nobuyuki Y ,Tsutomu D ,Hideki Y ,Yukihiro N ,Tetsuo A.Differences in umbilical cord serum lipid levels with mode of delivery.British Journal of Obstetrics and Gynaecology ,1999;106 :144- 147

Pecks U, Brieger M, Schiessl B, Bauerschlag DO, Piroth D, Bruno B, Fitzner C, Orlikowsky T, Maass N, Rath W. Maternal and fetal cord blood lipids in intrauterine growth restriction. J Perinat Med. 2012 Jan 6;40[3]:287-96.

Parker CR Jr, Fortunato SJ, Carr BR, Owen J, Hankins GD, Hauth JC. Apolipoprotein A-1 in umbilical cord blood of newborn infants: relation to gestational age and high-density lipoprotein cholesterol. Pediatr Res. 1988 Apr;23[4]:348-51.

Published

07-03-2024

How to Cite

JADHAO, A. N., T. D. RAMTEKE, and A. R. BARAPATRE. “EXPLORING LIPID VARIATIONS IN UMBILICAL CORD BLOOD ACROSS DIFFERENT DELIVERY MODES”. Asian Journal of Pharmaceutical and Clinical Research, vol. 17, no. 3, Mar. 2024, pp. 69-71, doi:10.22159/ajpcr.2024.v17i3.50533.

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