EFFECT OF ETHANOLIC EXTRACT OF BREADFRUIT (ARTOCARPUS ALTILIS [PARKINSON] FOSBERG) LEAVES ON AMELIORATING RENAL FUNCTION OF RAT

Authors

  • Dewi Safitri Institut Teknologi Bandung
  • Elin Yulinah Sukandar Institut Teknologi Bandung
  • Shafia Rachmamaryam Institut Teknologi Bandung

Abstract

Aims: Kidneys are one of the vital organs which belong to the urinary system. Renal failure occurs when the kidneys are unable to perform excretory
functions which are important in maintaining homeostasis. Breadfruit leaves are commonly used empirically for the treatment of renal failure.
Objectives: This study aims to determine the influence of breadfruit leaves ethanol extract (BLEE) to improve renal function in the renal failure rat
model.
Methods: Renal failure model was conducted by administering gentamicin 100 mg/kg body weight (bw) intraperitoneally for 7 days consecutively
and piroxicam 3.6 mg/kg bw for 5 weeks which was starting administered with gentamicin. BLEE were given for 4 weeks with dose of 50, 100, and
200 mg/kg bw, after gentamicin induction. Renal functions were evaluated by measuring urea and creatinine serum levels every week and renal
histology at the end of the experiment.
Results: After induction, urea and creatinine serum levels increased up to 5 times (p<0.05). Both parameters in all groups went up until the 2
week
and dropped on the 3
week. There was a significant difference in urea and creatinine serum levels in rats treated by BLEE 200 mg/kg. Histological
results depicted an improvement of the kidney structure. That treated by BLEE 200 mg/kg showed similarities appearance with the normal.
rd
Conclusion: BLEE improved the kidney function in the renal failure model which was showed by reduction on the levels of serum urea and creatinine
and restore kidneys structure. BLEE 200 mg/kg bw showed better activity on ameliorating renal function.
Keywords: Renal failure, Serum urea, Serum creatinine, Breadfruit leaves, Gentamicin, Piroxicam.
nd

Downloads

Download data is not yet available.

Author Biographies

Dewi Safitri, Institut Teknologi Bandung

School of Pharmacy

Elin Yulinah Sukandar, Institut Teknologi Bandung

School of Pharmacy

Shafia Rachmamaryam, Institut Teknologi Bandung

School of Pharmacy

References

Martini FH. Fundamentals of Anatomy and Physiology. 9

ed. San

Fransisco: Pearson; 2012. p. 954-64.

Horne, Mima M. dan Pamela LS. Keseimbangan Cairan, Elektrolit, &

Asam Basa. Jakarta: Penerbit Buku Kedokteran EGC; 2001. p. 213.

Chrisholm-Burns MA, Wells BG, Shwinghammer TL, Malone PM,

Kolesar JM, Dipiro JT. Pharmacotherapy Principles and Practice. Ch.

-26. New York: McGraw Hill Education Press; 2013.

th

Dipiro JT, Talbert RL, Yee GC, Matzke GR, Wells BG, Posey LM.

Pharmacotherapy A Pathophysiologic Approach. 7

ed. New York:

McGraw Hill; 2008. p. 723-5.

th

Ramadhani N. Uji toksisitas akut ekstrak etanol daun breadfruit

(Artocarpus altilis) terhadap larva artemia salina leach dengan

metode brine shrimp lethality test (BST), Theses Book of Universitas

Diponegoro. 2009. p. 1-6.

Akanni OO, Owumi SE, Adaramoye OA. In vitro studies to asses the

antioxidative, radical scavenging and arginase inhibitory potentials of

extracts from artocarpus altilis, Ficus exasperate and Kigelia Africana.

Asian Pac J Trop Biomed 2014;4 Suppl 1:492-9.

Muharram R, Sius E. Daya hambat ekstrak metanol daun breadfruit

(Artocarpus communis Forst) terhadap Pertumbuhan Bakteri

Pseudomonas aeruginosa dan Staphylococcus aureus Penyebab Infeksi

Pada Luka. J Kajian Penelitian dan Pengajaran Biol 2008;9:2.

Lin JA, Chen HC, Yen GC. The preventive role of breadfruit against

inflammation-associated epithelial carcinogenesis in mice. Mol Nutr

Food Res 2014;58(1):206-10.

Sikarwar MS, Hui BJ, Subramaniam K, Valeisamy BD, Yean LK,

Balaji K. Antioxidant activity of Artocarpus altilis (Parkinson) Fosberg

leaves. Free Radic Res 2014;4(2):33-9.

Arung TE. Anti-cancer properties of diethylether extract of wood from

breadfruit (Artocarpus altilis) in human breast cancer (T47D) cells.

Trop J Pharm Res 2009;8(4):317-24.

Adaramoye OA, Akanni OO. Effects of methanol extract of breadfruit

(Artocarpus altilis) on atherogenic indices and redox status of cellular

system of hypercholesterolemic Male rats. Adv Pharmacol Sci

;2014:11.

Sukandar EY, Fidrianny I, Adiwibowo LF. Efficacy of ethanol extract

of Andredera cordifolia (Ten.). Steenis leaves on improving kidney

failure in rats. Int J Pharmacol 2011;7(8):850-5.

Lakshrni BV, Sudhakar M. Protective effect of Zingiber officinale

on gentamicin-induced nephrotoxicity in rats. Int J Pharmacol

;6:58-62.

Walker PD, Shah SV. Evidence suggesting a role for hydroxyl

radical in gentamicin-induced acute renal failure in rats. J Clin Invest

;81(2):334-41.

Ali BH, Ismail TH, Bashir AA. Sex difference in the susceptibility

of rats to gentamicin nephrotoxicity: Influence of gonadectomy and

hormonal replacement therapy. Indian J Pharmacol 2001;33:369-71.

Erdem A, Gündogan NU, Usubütün A, Kilinç K, Erdem SR, Kara A,

et al. The protective effect of taurine against gentamicin-induced acute

tubular necrosis in rats. Nephrol Dial Transplant 2000;15(8):1175-82.

Hosaka EM, Santos OF, Seguro AC, Vattimo MF. Effect of

cyclooxygenase inhibitors on gentamicin-induced nephrotoxicity in

rats. Braz J Med Biol Res 2004;37:979-85.

Baliga R, Ueda N, Walker PD, Shah SV. Oxidant mechanisms in toxic

acute renal failure. Drug Metab Rev 1999;31(4):971-97.

Polat A, Parlakpinar H, Tasdemir S, Colak C, Vardi N, Ucar M, et al.

Protective role of aminoguanidine on gentamicin-induced acute renal

failure in rats. Acta Histochem 2006;108:365-71.

Mingeot-Leclercq MP, Tulkens PM. Aminoglycosides: Nephrotoxicity.

Antimicrob Agents Chemother 1999;43:1003-12.

Palupi DH. Pengaruh Pemberian Ekstrak Etanol Daun Sukun Terhadap

Perbaikan Tikus Yang Diinduksi Multiple Sclerosis. Buku Thesis,

Sekolah Farmasi, Institute Teknologi Bandung. 2011.

Pradhan C, Mohanty M. Phytoconstituent analysis and comparative

bioefficacy assessment of breadfruit leaf and fruit extracts for

antipathogenic potentiality. AJPCT 2014;2(1):77-87.

Sikarwar MS, Hui B, Subramaniam K, Valeisamy BD, Yean LK,

Balaji K. Pharmacognostical, phytochemical and total phenolic content

of Artocarpus altilis (Parkinson) fosberg leaves. J Appl Pharm Sci

;5(05):094-100.

Riasari H, Ruslan K. Metabolite profile of various development

bread fruit leaves (Artocarpus altilis. Parkinson. Fosberg) and

the identification of their major componens. Int J Pharm Sci Res

;6(5):2170.

De Souza VB, de Oliveira RF, de Lucena HF, Ferreira AA, Guerra GC,

Freitas ML, et al. Gentamicin induces renal morphopathology in Wistar

rats. Int J Morphol 2009;27(1):59-63.

Martínez-Salgado C, Eleno N, Morales AI, Pérez-Barriocanal F,

Arévalo M, López-Novoa JM. Gentamicin treatment induces

simultaneous mesangial proliferation and apoptosis in rats. Kidney Int

;65(6):2161-71.

Published

01-01-2016

How to Cite

Safitri, D., E. Y. Sukandar, and S. Rachmamaryam. “EFFECT OF ETHANOLIC EXTRACT OF BREADFRUIT (ARTOCARPUS ALTILIS [PARKINSON] FOSBERG) LEAVES ON AMELIORATING RENAL FUNCTION OF RAT”. Asian Journal of Pharmaceutical and Clinical Research, vol. 9, no. 1, Jan. 2016, pp. 215-8, https://journals.innovareacademics.in/index.php/ajpcr/article/view/9594.

Issue

Section

Original Article(s)

Most read articles by the same author(s)

<< < 1 2