DIURETIC ACTIVITY OF MATOA LEAVES EXTRACTS (Pometiapinnata) AND ITS INFLUENCE ON POTASSIUM AND SODIUM LEVELS

Authors

  • Ika Purwidyaningrum Department of School of Pharmacy, Bandung Institute of Technology, Indonesia
  • Elin Yulinah Sukandar Department of School of Pharmacy, Bandung Institute of Technology, Indonesia
  • Irda Fidrianny Department of School of Pharmacy, Bandung Institute of Technology, Indonesia

DOI:

https://doi.org/10.22159/ajpcr.2017.v10s2.19481

Keywords:

Matoa (Pometiapinnata), Diuretic, Urine volume, Potassium levels, Sodium levels

Abstract

Objective: The purpose of this study was to determine diuretic activity of matoa leaves (Pometiapinnata) extracts and fraction and its influence on potassium and sodium levels.

Methods: Matoa leaves were extracted by reflux method followed by evaporation using rotary evaporator. The subjects were male Wistar rats that were divided into 11 group furosemide (3.6 mg/kg bw), control group CMC 0.5%, matoa leaves extracts with doses of 50 mg/kg bw, 100 mg/kg bw, 150 mg/kg bw, matoa leaves aqueous fraction with dose of 10.94 mg/kg bw, 21.88 mg/kg bw, 32.82 mg/kg bw, matoa leaves ethyl acetate fraction with dose of 4.35 mg/kg bw, 8.71 mg/kg bw, 13.06 mg/kg bw. Rats were placed in metabolic cagesduring observation study. Urine volume was measured for 5 to 24 hours. Potassium and sodium levels in urine were determined by using Atomic Absorption Spectrophotometry.

Results: The effective dose of matoa leaves extract and fractions for diuretic activity was matoaleaves ethyl acetate fraction 8.71 mg/kg bw which could increase the excretion of sodium and potassium in the urine of the male Wistar rats.

Conclusion:Matoa leaves extract and fractions could increase the excretion of sodium and potassium in the urine of the male Wistar rats.

 

 

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Published

01-05-2017

How to Cite

Purwidyaningrum, I., E. Y. Sukandar, and I. Fidrianny. “DIURETIC ACTIVITY OF MATOA LEAVES EXTRACTS (Pometiapinnata) AND ITS INFLUENCE ON POTASSIUM AND SODIUM LEVELS”. Asian Journal of Pharmaceutical and Clinical Research, vol. 10, no. 14, May 2017, pp. 31-34, doi:10.22159/ajpcr.2017.v10s2.19481.

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