EFFICACY OF MOUTH RINSE FORMULATION BASED ON CETYLPYRIDINIUM CHLORIDE 0.1% IN THE CONTROL OF DENTAL CALCULUS BUILDUP
DOI:
https://doi.org/10.22159/ijap.2017.v9s1.84_91Keywords:
Mouth rinse, Cetylpyridinium chloride, AnticalculusAbstract
Objective: This study aimed at comparing the antiplaque, anticalculus, and antigingivitis potentials of a mouth rinse containing essential oil, alcohol,
zinc, and fluoride with a mouth rinse containing cetylpyridinium chloride (CPC) 0.1% over 1-, 2-, and 3-month periods.
Methods: This study was a double-blind, parallel randomized clinical trial with a 3-day run-in phase. Respondents were asked to gargle twice daily
with 15 ml of mouth rinse for 30 seconds after brushing teeth. Respondents were 80 females with a mean age of 21 years, and a single dental examiner
was employed throughout the study to decrease the variance. Prophylaxis was performed for all respondents before the intervention. Three mouth
rinses were tested: Group 1 with the mouth rinse containing CPC 0.1%, Group 2 as the negative control, and Group 3 as the positive control with a
mouth rinse containing alcohol. Evaluations were conducted by plaque index, gingival index, calculus index, and CariScreen examinations.
Results: The clinical trial showed that the mouth rinse with alcohol and the mouth rinse containing CPC 0.1% were effective in inhibiting bacterial
buildup (antiplaque) and have anticalculus properties, but with no statistically significant antigingivitis effect.
Conclusion: It was found that the mouth rinse containing alcohol has similar effectiveness with CPC 0.1% mouth rinse, but side effects, such as a
burning sensation, were reported in the alcohol-containing mouth rinse.
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Mouth rinse After 1 month After 2 months After 3 months
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*p‑value<0.05
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0 0.17 0.17 0.31 0.000
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