EFFICACY OF LOZENGES CONTAINING KEPEL FRUIT (STELECHOCARPUS BURAHOL) EXTRACT FOR CONTROLLING ORAL MALODOR
Keywords:Oral malodor, Halitosis, Volatile sulfur compound, Stelechocarpus burahol, Kepel
Objective: The aim of this study was to determine the effect of lozenges containing kepel fruit (Stelechocarpus burahol) in controlling oral malodor.
Methods: This study used crossover randomized control trial design. Each of the 30 research subjects received all three treatments at different
times: Kepel, xylitol, and placebo lozenges. The subjects used lozenges in the morning after breakfast and afternoon after lunch. Examinations of oral
malodor were performed thrice: Immediately after waking up, after breakfast, and after lunch. Measured oral odor variables included organoleptic
score and H2S, CH3SH, and (CH3)2S levels.
Results: Effect of burahol fruit extract lozenges was comparable to that of xylitol gum in reducing the H2S, CH3SH, and (CH3)2S levels and organoleptic
scores of the subjects.
Conclusion: Lozenges containing burahol fruit extract were effective in controlling oral malodor (halitosis).
Darusman HS. Indonesian kepel fruit (Stelechocarpus burahol) as oral
deodorant. Res J Med Plant 2012;6:180-8.
Molyneux P. The use of the stable free radical diphenylpicrylhydrazyl
(DPPH) for estimating antioxidant activity. Songklanakarin J Sci
Fukui Y, Yaegaki K, Murata T, SatoT, Tanaka T, Imai T, et al. Diurnal
changes in oral malodor among dental-office workers. Int Dent J
Ahmadi S, Marino T, Prejano M, Russo N, Toscano M. Antioxidant
properties of the vam3 derivative of resveratrol. Molecules
Lu JM, Lin PH, Yao Q, Chen C. Chemical and molecular mechanisms
of antioxidants: Experimental approaches and model systems. J Cell
Mol Med 2010;14:840-60.
Khanduja KL, Bhardwaj A. Stable free radical scavenging and
antiperoxidative properties of resveratrol compared in vitro with some
other bioflavonoids. Indian J Biochem Biophys 2003;40:416-22.
Devi NB, Jagetia GC. Free radical scavenging and antioxidant potential
of different extracts of Colocasia gigantea (Blume) Hook. F. In vitro.
Int Res J Pharm 2017;8:72-81.
Mantle D, Wilkins RM, Gok MA. Comparison of antioxidant activity
in commercial Ginkgo biloba preparations. J Altern Complement Med
Heo SJ, Kim JP, Jung WK, Lee NH, Kang HS, Jun EM, et al.
Identification of chemical structure and free radical scavenging activity
of diphlorethohydroxycarmalol isolated from a brown alga, Ishige
okamurae. J Microbiol Biotechnol 2008;18:676-81.
Negishi O, Negishi Y, Aoyagi Y, Sugahara T, Ozawa T. Mercaptancapturing
properties of mushrooms. J Agric Food Chem
Snel J, Burgering M, Smit B, Noordman W, Tangerman A, Winkel AG,
et al. Volatile sulfur compounds in morning breath of human volunteers.
Arch Oral Biol 2011;56:29-34.
Amin A, Radji M, Munâ€™im A, Rahardjo A, Suryadi H. Halitosis activity
against volatile sulfur compound of methyl mercaptan component from
burahol (Stelechocarpus burahol) fruits extract. Asian J Pharm Clin