STRATEGY TO MASK THE BITTER TASTE OF MOMORDICA CHARANTIA EXTRACT USING ALGINATE–GELATIN BEADS

Authors

  • Sutriyo Laboratory of Pharmaceutics and Pharmaceutical Technology Development, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424,Indonesia.
  • Raditya Iswandana Laboratory of Pharmaceutics and Pharmaceutical Technology Development, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia.
  • Fauzana Fauzi Laboratory of Pharmaceutics and Pharmaceutical Technology Development, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia.

DOI:

https://doi.org/10.22159/ijap.2018.v10s1.84

Keywords:

Alginate, Beads, Bitter melon extract (Momordica charantia Linn), Bitter taste masking, Gelatin

Abstract

Objective: This study is aimed to develop a strategy to mask the bitter taste of Momordica charantia Linn. extract using alginate–gelatin beads.
Methods: Beads of bitter melon fruit extract (M. charantia Linn) were prepared using an ionic gelation method in which cross-linking occurs between
sodium alginate and calcium chloride that serves to mask the bitter taste. Beads were prepared using sodium alginate (1.5% w/v) with various
concentrations of bitter melon fruit extract (1:2, 1:1, and 1:0.5), gelatin (2% w/v), and CaCl2 3%. The obtained beads were then characterized both
physically and functionally, and their morphology, process efficiency, particle distribution, swelling index, and water content were recorded.
Results: Formula 1 beads, with a 1:2 ratio of extract: alginate, displayed a near-round shape with a diameter of 600–1 200 μm, a swelling index of
113.21%, and a moisture content of 15.34%. In addition, these beads were able to significantly cover the bitter taste (p<0.05).
Conclusion: Formula 1 beads with a 1:2 ratio of extract: alginate can effectively mask the bitter taste of M. charantia Linn.

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References

Xu X, Shan B, Liao CH, Xie JH, Wen PW, Shi JY. Anti-diabetic

properties of Momordica charantia L. Polysaccharide in alloxaninduced

diabetic mice. Int J Biol Macromol 2015;81:538-43.

Semiz A, Sen A. Antioxidant and chemoprotective properties of

Momordica charantia L (bitter melon) fruit extract. Afr J Biotechnol

;6:273-7.

Puri M, Kaur I, Kanwar RK, Gupta RC, Chauhan A, Kanwar JR.

Ribosome inactivating proteins (RIPs) from Momordica charantia for

anti viral therapy. Curr Mol Med 2009;9:1080-94.

Tan H, Gan C. Polysaccharide with antioxidant, α-amylase inhibitory

and ACE inhibitory activities from Momordica charantia. Int J Biol

Macromol 2016;85:487-96.

Zhang F, Lin L, Xie J. A mini-review of chemical and biological

properties of polysaccharides from Momordica charantia. Int J Biol

Macromol 2016;92:246-53.

Donya AB. The Effects of Various Processing Methods on the

Momordicosides K and L Contents, and the Sensory Characteristics

of Bitter Melon Vegetable (Momordica charantia L.). United States:

University of Arkansas; 2007.

Gupta M, Sharma S, Gautam AK, Bhadauria R. Momordica charantia

Linn. (Karela): Nature’s silent healer. Int J Pharm Sci Rev Res

;11:32-7.

Limtrakul P, Pitchakarn P, Suzuki S, Kuguacin J. A triterpenoid

from Momordica charantia Linn: A comprehensive review of

anticarcinogenic properties. Open Sci 2013;13:276-96.

Devi NKD, Chandana M, Sindhura A, Ratnavali G, Kavitha R.

Comparative evaluation of alginate beads prepared by ionotropic

gelation technique. Pharmacopore 2010;3:196-213.

Tønnesen HH, Karlsen J. Alginate in drug delivery systems. Drug Dev

Ind Pharm 2002;28:621-30.

Dong Z, Wang Q, Du Y. Alginate/gelatin blend films and their

properties for drug controlled release. J Memb Sci 2006;280:

-44.

Saarai A, Kasparkova V, Sedlacek T, Saha P. On the development and

characterisation of crosslinked sodium alginate/gelatine hydrogels.

J Mech Behav Biomed Mater 2013;18:152-66.

Kumar SR, Ashish J, Satish N. Momordica charantia Linn.: A mini

review. Int J Manag Bus Res 2011;2:579-87.

Harmita. Textbook of Physicochemical Analysis. Depok: Department

of Pharmacy, Faculty of Mathematics and Natural Sciences Universitas

Indonesia; 2006.

Namasivayam SK, Robin AT. Preparation, optimization and

characterization of biocompatible nanoalbumin-ofloxacin (BSANP‑OF)

conjugate and evaluation of control release, anti bacterial activity

against clinical isolate of Pseudomonas aeruginosa. Asian J Pharm Clin

Res 2013;6:235-39.

Nagavarma BV, Hemant KS, Ayaz A, Vasudha LS, Shivakumar HG.

Different techniques for preparation of polymeric nanoparticles - A

review. Asian J Pharm Clin Res 2012;5:16-23.

Farshid A, Lakshmi CS. Formulation of nanoparticles of antti-migraine

drugs triptans by coacervation method. Asian J Pharm Clin Res

;10:122-8.

Published

20-12-2018

How to Cite

Sutriyo, Iswandana, R., & Fauzi, F. (2018). STRATEGY TO MASK THE BITTER TASTE OF MOMORDICA CHARANTIA EXTRACT USING ALGINATE–GELATIN BEADS. International Journal of Applied Pharmaceutics, 10(1), 381–383. https://doi.org/10.22159/ijap.2018.v10s1.84

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