FORMULATION OF SUSPENDING VEHICLES FOR EXTEMPORANEOUS ORAL LIQUID COMPOUNDING WITH DILTIAZEM HYDROCHLORIDE AS A DRUG MODEL
DOI:
https://doi.org/10.22159/ijap.2018.v10s1.51Keywords:
Diltiazem hydrochloride, Suspending vehicle, Extemporaneous oral liquid formulation, StabilityAbstract
Objective: This study aimed to determine the optimum concentrations of a suspending vehicle and develop a physically and chemically stable
formulation containing diltiazem hydrochloride (DTZ).
Methods: Stability testing was performed for 30 days in selected suspending vehicle formulas (Formulas A and E). Physical stability tests were
performed at room temperature, and physical properties (odor and color) and pH values of suspensions were evaluated.
Results: The oral suspensions of DTZ were white and had a drug-like odor, and the pH had significantly decreased during storage. Chemical stability
tests of suspensions were performed at room temperature and 4°C±2°C using ultraviolet-visible spectrophotometry.
Conclusion: The concentrations of DTZ in oral suspensions fluctuated during the storage period, suggesting that the oral suspensions of DTZ are
physically stable but not chemically stable during storage.
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