PROPHYLACTIC ANTIBIOTICS ALONE VERSUS COMBINED PROPHYLAXIS AND POSTOPERATIVE ANTIBIOTICS FOR PREVENTING SURGICAL-SITE INFECTIONS ASSOCIATED WITH EAR AND NOSE RECONSTRUCTIVE SURGERY
DOI:
https://doi.org/10.22159/ijap.2019.v11s6.33534Keywords:
Ear reconstructive surgery, Nose reconstructive surgery, Postoperative antibiotic, Prophylactic antibiotic, Surgical-site infectionAbstract
Objective: The aim of this study was to acquire supporting data for the rational use of antibiotics in plastic reconstructive surgery in the Ear-Nose-Throat/Head and Neck Surgery Department at Cipto Mangunkusumo Hospital–Faculty of Medicine Indonesia University.
Methods: This pilot study, with a negative trial design, included 12 subjects who were randomly divided into two groups: preoperative prophylactic antibiotic-only group and a combination of prophylactic and postoperative antibiotic group (controls).
Results: The results showed that only 1 of the 12 subjects (in the prophylactic antibiotic-only group) developed an SSI. None of the controls (combined-use group) had an SSI. The difference between the two groups was not significant.
Conclusion: The use of postoperative antibiotic appears not to be necessary in plastic reconstructive surgery patients to prevent SSIs. Further study, however, is required to support the findings of this study.
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References
1. Salkind AR, Rao KC. Antibiotic prophylaxis to prevent surgical site infections. Am Fam Physician 2011;83:585–90.
2. Uçkay I, Harbarth S, Peter R, Lew D, Hoffmeyer P, Pittet D. Preventing surgical site infections. Expert Rev Anti Infect Ther 2010;8:657–70.
3. Saxena A, Singh MP, Brahmchari S, Banerjee M. Surgical site infection among postoperative patients of tertiary care centre in Central India: a prospective study. Asian J Biomed Pharm Sci 2013;3:41–4.
4. Spratt D, Dutton RP, Dellinger EP, Bird B, Guglielmi CL, Farber M, et al. The role of the health care professions in preventing surgical site infection. AORN J 2012;95:430–40.
5. Rosenberger LH, Sawyer RG. Surgical site infections. In: Cameron JL, Cameron AM. editors. In: Current Surgical Therapy. 11th Edition. 11th ed. Elsevier; 2014. p. 1172–7.
6. Noorani A, Rabey N, Walsh SR, Davies RJ. Systematic review and meta-analysis of preoperative antisepsis with chlorhexidine versus povidone-iodine in clean-contaminated surgery. Br J Surg 2010;97:1614–20.
7. Darouiche RO, Wall MJ Jr, Itani KM, Otterson MF, Webb AL, Carrick MM, et al. Chlorhexidine–alcohol versus povidone–iodine for surgical-site antisepsis. N Engl J Med 2010;362:18–26.
8. Loho T, Astrawinata DA. Bacterial and antibiotics susceptibility profile at cipto mangunkusumo general hospital Jan–Jun 2015. 1st edition. Loho T. editor. Jakarta: Division of Infectious Disease, Department of Clinical Pathology Cipto Mangunkusumo General Hospital; 2015. p. 171–5.
9. Van Boeckel TP, Gandra S, Ashok A, Caudron Q, Grenfell BT, Levin SA, et al. Global antibiotic consumption 2000 to 2010:an analysis of national pharmaceutical sales data. Lancet Infect Dis 2014;14:742–50.
10. Chen L, Gajendrareddy PK, DiPietro LA. Differential expression of HIF-1? in skin and mucosal wounds. J Dent Res 2012;91:871–6.
11. Nwankwo EO, Ibeh I, Enabulele OI. Incidence and risk factors of surgical site infection in a tertiary health institution in Kano, northwestern Nigeria. Int J Infect Control 2012;8:8–13.
12. Bratzler DW, Dellinger EP, Olsen KM, Perl TM, Auwaerter PG, Bolon MK, et al. Clinical practice guidelines for antimicrobial prophylaxis in surgery. Am J Heal Pharm 2013;70:195–283.
13. Shankar RP, Partha P, Shenoy NK, Easow JM, Brahmadathan KN. Prescribing patterns of antibiotics and sensitivity patterns of common microorganisms in the internal medicine ward of a teaching hospital in Western Nepal: a prospective study. Ann Clin Microbiol Antimicrob 2003;2:7.
14. Collier M, E Ans D Vid, Farrington M, Gibbs E, Gould K, Kathryn HJ, et al. Surgical site infection: prevention and treatment of surgical site infection. In: National Institute for Health and Care Excellence-Clinical Guidelines [Internet]; 2008. p. 168.
15. Murakami C, Quatela V, Sie K, Shyidler J. Microtia reconstruction. In: Flint PW, Haughey BH, Lund VJ, Richardson MA, Robbins KT, Thomas JR, et al. editors. Cummings Otolaryngology Head and Neck Surgery. 5th ed. Philladelphia: Mosby Elsevier; 2010. p. 2741–51.
16. Kelley PE, Scholes MA. Microtia and congenital aural atresia. Otolaryngol Clin North Am 2007;40:61–80.
17. Biggs TC, Nightingale K, Patel NN, Salib RJ. Should prophylactic antibiotics be used routinely in epistaxis patients with nasal packs? Ann R Coll Surg Engl 2013;95:40–2.
18. Andrews PJ, East CA, Jayaraj SM, Badia L, Panagamuwa C, Harding L. Prophylactic vs postoperative antibiotic use in complex septorhinoplasty surgery: a prospective, randomized, single-blind trial comparing efficacy. Arch Facial Plast Surg 2006;8:84–7.
19. Rosenfeld RM, Piccirillo JF, Chandrasekhar SS, Brook I, Ashok Kumar K, Kramper M, et al. Clinical practice guideline (update): adult sinusitis. Otolaryngol Head Neck Surg 2015;152(Suppl):S1–39.
20. Stevens DL, Bisno AL, Chambers HF, Everett D, Dellinger P, Goldstein EJC, et al. Practice guidelines for the diagnosis and management of skin and soft-tissue infections. Clin Infect Dis 2005;41:1373–406.
21. Daniel RK. A basic rhinoplasty operation. In: Mastering rhinoplasty a comprehensive atlas of surgical techniques with integrated video clips. Springer; 2010. p. 13–66.
22. Pittet D. Hand hygiene in health care first global patient safety challenge clean care is safer care. World Health 2009;30:270.
23. Gurtner GC. Wound healing: normal and abnormal. In: Thorne C. editor. Grabb and Smith’s Plastic Surgery. 6th edition. Lippincott Williams and Wilkins; Philadelphia; 2007. p. 1522.
24. Verwoerd-Verhoef HL, Koppel PG, Osch GJ van, Meeuwis CA, Verwoerd C DA. Wound healing and cartilage structures in the head and neck region. Wound Heal Distortion Gener Cartil 2005;43:17–30.
25. Russel EJ, Czarvionke L, Huckman M, Daniels D, McLachlan D. CT of the inferomedial orbit and the lacrimal drainage apparatus: normal and pathologic anatomy. Am J Roentgenol 1985;145:1147–54.
2. Uçkay I, Harbarth S, Peter R, Lew D, Hoffmeyer P, Pittet D. Preventing surgical site infections. Expert Rev Anti Infect Ther 2010;8:657–70.
3. Saxena A, Singh MP, Brahmchari S, Banerjee M. Surgical site infection among postoperative patients of tertiary care centre in Central India: a prospective study. Asian J Biomed Pharm Sci 2013;3:41–4.
4. Spratt D, Dutton RP, Dellinger EP, Bird B, Guglielmi CL, Farber M, et al. The role of the health care professions in preventing surgical site infection. AORN J 2012;95:430–40.
5. Rosenberger LH, Sawyer RG. Surgical site infections. In: Cameron JL, Cameron AM. editors. In: Current Surgical Therapy. 11th Edition. 11th ed. Elsevier; 2014. p. 1172–7.
6. Noorani A, Rabey N, Walsh SR, Davies RJ. Systematic review and meta-analysis of preoperative antisepsis with chlorhexidine versus povidone-iodine in clean-contaminated surgery. Br J Surg 2010;97:1614–20.
7. Darouiche RO, Wall MJ Jr, Itani KM, Otterson MF, Webb AL, Carrick MM, et al. Chlorhexidine–alcohol versus povidone–iodine for surgical-site antisepsis. N Engl J Med 2010;362:18–26.
8. Loho T, Astrawinata DA. Bacterial and antibiotics susceptibility profile at cipto mangunkusumo general hospital Jan–Jun 2015. 1st edition. Loho T. editor. Jakarta: Division of Infectious Disease, Department of Clinical Pathology Cipto Mangunkusumo General Hospital; 2015. p. 171–5.
9. Van Boeckel TP, Gandra S, Ashok A, Caudron Q, Grenfell BT, Levin SA, et al. Global antibiotic consumption 2000 to 2010:an analysis of national pharmaceutical sales data. Lancet Infect Dis 2014;14:742–50.
10. Chen L, Gajendrareddy PK, DiPietro LA. Differential expression of HIF-1? in skin and mucosal wounds. J Dent Res 2012;91:871–6.
11. Nwankwo EO, Ibeh I, Enabulele OI. Incidence and risk factors of surgical site infection in a tertiary health institution in Kano, northwestern Nigeria. Int J Infect Control 2012;8:8–13.
12. Bratzler DW, Dellinger EP, Olsen KM, Perl TM, Auwaerter PG, Bolon MK, et al. Clinical practice guidelines for antimicrobial prophylaxis in surgery. Am J Heal Pharm 2013;70:195–283.
13. Shankar RP, Partha P, Shenoy NK, Easow JM, Brahmadathan KN. Prescribing patterns of antibiotics and sensitivity patterns of common microorganisms in the internal medicine ward of a teaching hospital in Western Nepal: a prospective study. Ann Clin Microbiol Antimicrob 2003;2:7.
14. Collier M, E Ans D Vid, Farrington M, Gibbs E, Gould K, Kathryn HJ, et al. Surgical site infection: prevention and treatment of surgical site infection. In: National Institute for Health and Care Excellence-Clinical Guidelines [Internet]; 2008. p. 168.
15. Murakami C, Quatela V, Sie K, Shyidler J. Microtia reconstruction. In: Flint PW, Haughey BH, Lund VJ, Richardson MA, Robbins KT, Thomas JR, et al. editors. Cummings Otolaryngology Head and Neck Surgery. 5th ed. Philladelphia: Mosby Elsevier; 2010. p. 2741–51.
16. Kelley PE, Scholes MA. Microtia and congenital aural atresia. Otolaryngol Clin North Am 2007;40:61–80.
17. Biggs TC, Nightingale K, Patel NN, Salib RJ. Should prophylactic antibiotics be used routinely in epistaxis patients with nasal packs? Ann R Coll Surg Engl 2013;95:40–2.
18. Andrews PJ, East CA, Jayaraj SM, Badia L, Panagamuwa C, Harding L. Prophylactic vs postoperative antibiotic use in complex septorhinoplasty surgery: a prospective, randomized, single-blind trial comparing efficacy. Arch Facial Plast Surg 2006;8:84–7.
19. Rosenfeld RM, Piccirillo JF, Chandrasekhar SS, Brook I, Ashok Kumar K, Kramper M, et al. Clinical practice guideline (update): adult sinusitis. Otolaryngol Head Neck Surg 2015;152(Suppl):S1–39.
20. Stevens DL, Bisno AL, Chambers HF, Everett D, Dellinger P, Goldstein EJC, et al. Practice guidelines for the diagnosis and management of skin and soft-tissue infections. Clin Infect Dis 2005;41:1373–406.
21. Daniel RK. A basic rhinoplasty operation. In: Mastering rhinoplasty a comprehensive atlas of surgical techniques with integrated video clips. Springer; 2010. p. 13–66.
22. Pittet D. Hand hygiene in health care first global patient safety challenge clean care is safer care. World Health 2009;30:270.
23. Gurtner GC. Wound healing: normal and abnormal. In: Thorne C. editor. Grabb and Smith’s Plastic Surgery. 6th edition. Lippincott Williams and Wilkins; Philadelphia; 2007. p. 1522.
24. Verwoerd-Verhoef HL, Koppel PG, Osch GJ van, Meeuwis CA, Verwoerd C DA. Wound healing and cartilage structures in the head and neck region. Wound Heal Distortion Gener Cartil 2005;43:17–30.
25. Russel EJ, Czarvionke L, Huckman M, Daniels D, McLachlan D. CT of the inferomedial orbit and the lacrimal drainage apparatus: normal and pathologic anatomy. Am J Roentgenol 1985;145:1147–54.
Published
15-12-2019
How to Cite
KOENTO, T., & SALEH, R. R. (2019). PROPHYLACTIC ANTIBIOTICS ALONE VERSUS COMBINED PROPHYLAXIS AND POSTOPERATIVE ANTIBIOTICS FOR PREVENTING SURGICAL-SITE INFECTIONS ASSOCIATED WITH EAR AND NOSE RECONSTRUCTIVE SURGERY. International Journal of Applied Pharmaceutics, 11(6), 37–41. https://doi.org/10.22159/ijap.2019.v11s6.33534
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