UTILIZATION RED DRAGON FRUIT PEEL (HYLOCEREUS POLYRHIZUS) ETHANOL EXTRACT IN ORAL THIN FILM STRIP AS A MOUTH FRESHENER

NABILA APRILIANI; LIA LAILA; BAYU EKO PRASETYO

doi:10.22159/ijap.2024v16i3.50043

Authors

NABILA APRILIANI Undergraduate Program, Faculty of Pharmacy, Universitas Sumatera Utara, Medan-20155, Indonesia https://orcid.org/0009-0000-5150-9921
LIA LAILA Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan-20155, Indonesia. Nanomedicine Centre of Innovation, Universitas Sumatera Utara-20155, Indonesia https://orcid.org/0000-0002-9343-5518
BAYU EKO PRASETYO Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan-20155, Indonesia. Nanomedicine Centre of Innovation, Universitas Sumatera Utara-20155, Indonesia https://orcid.org/0000-0002-6921-3288

DOI:

https://doi.org/10.22159/ijap.2024v16i3.50043

Keywords:

Red dragon fruit peel, OTFS, Stability, Antibacterial activity

Abstract

Objective: The aim of this study was to formulate an oral thin film strip (OTFS) contained the red dragon fruit peel (RDFP) ethanol extract (Hylocereus polyrhizus) and evaluate the characteristic, stability, and antibacterial activity against Streptococcus mutans (S. mutans).

Methods: The film was made using the solvent casting method by adding a variety of concentration ethanol extract of red dragon fruit peel (5%, 10%, and 15%). The films were evaluated in organoleptic test, weight, thickness, pH, disintegration time, folding endurance, stability test and antibacterial activity.

Results: The results showed that the film provided a distinctive color, aroma, and taste of the extract. The result of film evaluation had weight between 0.07-0.21 g, thickness between 0.10-0.20 mm, pH between 5.70-5.99, disintegration time between 34.99-49.13 s, and folding endurance between 321.00-812.83 times. The films were stable for 2 months at variety storage temperature (4±2℃, 28±2℃, and 40±2℃). The films showed antibacterial activity for 5%, 10% and 15% with the diameter of inhibition 8.5 mm, 10.8 mm, and 12.9 mm, respectively.

Conclusion: Ethanol extract of RDFP can be utilized as a mouth freshener film that is stable for 2 months and has antibacterial activity against S. mutans.

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References

Homayun B, Lin X, Choi HJ. Challenges and recent progress in oral drug delivery systems for biopharmaceuticals. Pharmaceutics. 2019; 11(3). doi: 10.3390/pharmaceutics11030129.

Souza LF, Nascimento WV, Alves LMT, Silva ACV, Cassiani RA, Alves DC, Dantas RO. Medication swallowing difficulties in people without dysphagia. Revista CEFAC. 2019; 21(4): 1-7. doi: 10.1590/1982-0216/20192140119.

Llorca PM. Discussion of prevalence and management of discomfort when swallowing pills: Orodispersible tablets expand treatment options in patients with depression. Ther. Delivery. 2011; 2(5): 611-622. doi: 10.4155/tde.11.32.

Reddy TUK, Reddy KSK, Manogna K, Thyagaraju K. A detailed review on fast dissolving oral films. J. Pharm. Res. 2018; 8(06): 1351-1326.

Kumar KS, Mothilal M. Advancements in scaffold-based drug delivery system: A comprehensive overview and recent developments. Int J App Pharm. 2023;15(6):20-32. doi: 10.22159/ijap.2023v15i6.48645.

Kawale KA, Autade NB, Narhare HS, Mhetrea RL. A review on fast dissolving oral film. Asian J Pharm Clin Res. 2023; 16(10): 7-17. doi: 10.22159/ajpcr.2023.v16i10.48099.

Haju SS, Yadav S. Formulation and evaluation of cilnidipine mucoadhesive buccal film by solvent casting technique for the treatment of hypertension. Int J Pharm Pharm Sci. 2021;13(9):34-43. doi: 10.22159/ijpps.2021v13i9.42641.

Siddiqui MDN, Garg G, Sharma PK. A Short Review on A novel approach in oral fast dissolving drug delivery system and their patents conventional oral modified release fast action oral solid. Int. J. Pharm. Sci. Rev. Res. 2011; 5(6): 291-303.

Thakur P, Ratnaparkhi MP. Formulation and evaluation of mouth dissolving film of felodipine. Res. J. Pharm. Tech. 2014; 7(10): 1145-1149.

Sha A, Pravin S. Formulation and evaluation of mouth dissolving films of amlodipine besylate by using natural and synthetic polymers. Res. J. Pharm. Technol. 2022; 15(11): 5154-7. doi: 10.52711/0974-360X.2022.00867.

Farooqui P, Gude R. Formulation development and optimization of fast dissolving buccal film loaded glimepiride solid dispersion with enhanced dissolution profile using central composite design. Int J Pharm Pharm Sci. 2023; 15(6): 35-54. doi: 10.22159/ijpps.2023v15i6.47992.

P H, Fatima S, Formulation and evaluation of oral fast dissolving films of naproxen sodium. Int J Curr Pharm Res. 2022; 14(2): 48-53. doi: 10.22159/ijcpr.2022v14i2.1953.

Ramadhani A, Zettira Z, Rachmawati YL, Hariyani N, Maharani DA. Quality and reliability of halitosis videos on youtube as a source of information. Dent. J; 2021: 9(10): 1-9. doi: 10.3390/dj9100120.

Bicak DA. A current approach to halitosis and oral malodor- a mini review. Open Dent. J. 2018; 12(1): 322-330. doi: 10.2174/1874210601812010322.

Ritarwan K, Nerdy N. Antibacterial activity of red dragon fruit leaves extract and white dragon fruit leaves extract against meningitis bacterial. Orient. J. Chem. 2018; 34(5): 2534-2538. doi: 10.13005/ojc/340540.

Rahayu YS, Sabir A, Setyorini D. Antibacterial activity of red dragon fruit extract (Hylocereus polyrhizus) on Streptococcus mutans. Int. J. Appl. Pharm. 2019; 11(4): 60-63. doi: 10.22159/ijap.2019.v11s4.35293.

Waladi, Johan VS, Hamzah F. Utilization of red dragon fruit peel (Hylocereus polyrhizus) as an additive in the making of ice cream. Jom Faperta. 2015; 2(1): 1-11

Noor MI, Yufita E, Zulfalina. Identification content of the red dragon fruit extract skin using Fourier Transform Infrared (FTIR) and phytochemistry. J. Aceh Phys. Soc. 2016; 5(1): 14-16.

Indonesian Pharmacopoeia. 3rd Ed. Jakarta: Indonesian Ministry of Health. 1979

Harmely F, Deviarny C, Yenni WS. Formulation and evaluation of edible film from basil leaves extract (Ocimum americanum L.) as mouth freshner. J. Sains Farm Klin. 2014; 1(1): 38-47. doi: 10.29208/jsfk.2014.1.1.10.

Dewi WA, Mulya D. Formulation and evaluation of physical properties and stability test of edible film ethanol extract 96% celery (Apium graveolens L.) as mouth freshner. Іndones. Nаt. Rеѕ. Рhаrm. J. 2019; 4(2): 32-40.

Wahyuni YS, Rikmasari Y, Maulidiah R. Formulation and evaluation of edible film dosage form herbal combination used potatoes starch (Solanum tuberosum L.) as a polymer with a variance of sorbitol as a placticizers. J. Pharm. Sci. 2021; 4(1): 21-28. doi: 10.36490/journal-jps.com.v4i1.60.

Ningsih W, Arel A. Clove oil (Syzygium aromaticum) edible film formulation and antibacterial activity test against Streptococcus mutans. J. Fundam. Appl. Pharm. Sci. 2012; 2(1): 1-9. doi: 10.18196/jfaps.v2i1.11640.

Zubaydah WOS, Sahumena MH. Fast dissolving oral film salbutamol sulphate using HPMC polymer. Indones. J. Chemom. Pharm. Anal. 2021; 3: 133-142.

Irfan M, Rabel S, Bukhtar Q, Qadir MI, Jabeen F, Khan A. Orally disintegrating films: a modern expansion in drug delivery system. Saudi Pharm. J. 2016; 24(5): 537-546. doi: 10.1016/j.jsps.2015.02.024.

Ozakar RSm, Ozakar E. Current overview of oral thin films. Turk. J. Pharm. Sci. 2021; 18(1): 111-121. doi: 10.4274/tjps.galenos.2020.76390.

National Standardization Agency. Instructions for organoleptic and or sensory testing. Jakarta: National Standardization Body. 2006

Handayani DS, Pranoto, Saputra DA, Marliyana, SD. Antibacterial activity of polyeugenol against Staphylococcus aureus and Escherichia coli. IOP Conference Series: Materials Science and Engineering. 2019; 578(1): 13-19. doi: 10.1088/1757-899X/578/1/012061.

Nurhabibah N, Sriarumtias FF, Fauziah S, Auliasari N, Hindun S. Formulation and evaluation fast disintegrating film salbutamol sulfat using HPMC E15. J. Phys.: Conf. Ser. 2019; 5: 1-8. doi: 10.1088/1742-6596/1402/5/055093.

Herawati H. The hydrocolloids potential as additive materials to the qualified food and non-food products. J. Agric. Res Dev. 2018; 37(1): 17-25. doi: 10.21082/jp3.v37n1.2018.p17-25.

Warkoyo, Rahardjo B, Marseno DW, Karyadi JNW. Physical, mechanical and barrier properties of Xanthosoma sagittifolium starch-based edible film incorporated with potassium sorbate. Agritech. 2014; 34(1): 72-81.

Zhang H, Wang L, Li H, Chi Y, Zhang H, Xia N, Ma Y, Jiang L, Zhang X. Changes in properties of soy protein isolate edible films stored at different temperatures: studies on water and glycerol migration. Foods J. 2021; 10(8): 1-15. doi: 10.3390/foods10081797.

Zhang L, Aloia M, Safira BP, Lin H, Rajai PM, Kunnath K, Dave RN. Impact of super-disintegrants and film thickness on disintegration time of strip films loaded with poorly water-soluble drug microparticles. J. Pharm. Sci. 2018; 107(8): 2109-2118.

Salsabila A, Ulfah M. Characteristics of edible film thickness of bioselulosa nata de siwalan with glycerol addition. Bioma: Sci. J. Biol. 2017; 6(1): 1-9. doi: 10.26877/bioma.v6i1.1469.

Kanani N, Wardalia, Wardhono EY, Rusdi. The effect of dying temperature on the swelling and tensile strength of edible cassava peel starch film. Conv. J. 2017; 6(2): 75-82.

Rowe RC, Sheskey PJ, Quinn ME. Handbook of Pharmaceutical Excipients. London: Pharmaceutical Press. 2009.

Bishop P, Pitts ER, Budner D, Thompson-Witrick KA. Chemical composition of kombucha. Beverages. 2022; 8(3): 45. doi: 10.3390/beverages8030045.

Candra A, Prasetyo BE, Tarigan JB, Halim A. Potential of soursop leaves (Annona muricata L.) kombucha beverages on vitamin C content and antimicrobial activity. AIP Conf. Proc. 2023; 2626(1): doi: 10.1063/5.0136033.

Candra A, Prasetyo BE, Darge HF. Honey utilization in soursop leaves (Annona muricata) kombucha: physicochemical, cytotoxicity, and antimicrobial activity. Biocatal. Agric. Biotechnol. 2023; 52: 102815. doi: 10.1016/j.bcab.2023.102815.