USE OF SIMPLEX LATTICE DESIGN IN DEVELOPMENT OF ORAL SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM CONTAINING ROSUVASTATIN CALCIUM

NISHANT OZA; SWATI SAGAR; AKRUTI KHODAKIYA

doi:10.22159/ijap.2020v12i3.34358

Authors

NISHANT OZA C. U. Shah College of Pharmacy and Research, Wadhwan City, Gujarat, India
SWATI SAGAR C. U. Shah College of Pharmacy and Research, Wadhwan City, Gujarat, India
AKRUTI KHODAKIYA C. U. Shah College of Pharmacy and Research, Wadhwan City, Gujarat, India

DOI:

https://doi.org/10.22159/ijap.2020v12i3.34358

Keywords:

SNEDDS, Rosuvastatin Calcium, Simplex lattice design, Peceol, Ethyl Oleate, Labrasol, Cremophore EL

Abstract

Objective: The aim of the present work was to enhance the solubility of rosuvastatin calcium by self-nano emulsifying drug delivery system (SNEDDS) using mixtures of oil, cosolvent, surfactant and cosurfactant.

Methods: Based on solubility study and emulsification efficiency, Preliminary investigations of various oils, surfactants and cosurfactants were carried out for the selection of the proper SNEDDS ingredients. Pseudo-ternary phase diagrams were constructed to identify the efficient self-emulsification region. A series of SNEDDS formulations were prepared using labrasol: cremophor EL with a combination of peceol: ethyl oleate by using the simplex lattice design. Prepared formulation evaluated for refractive index, turbidimetric, droplet size, zeta potential and polydispersity index, self-emulsification, stability tests, viscosity and in vitro diffusion studies.

Results: The best formula for SNEDDS in the current study were: 15% oil (peceol: ethyloleatein 1:1 ratio), 50% Labrasol and 35% Cremophor EL. All the SNEDDS batches globule size was found to be varied from 22.90±1.50 nm to 43.90±1.40 nm. and no significant variations in globule size were observed after 3 mo stability studies. All the batches % transparency was found to be varied from 95.40±1.40% to 99.50±1.10% and drug diffused in 10 min varied from 63.65±1.51% to 93.72±1.46 %.

Conclusion: The data suggest the use of rosuvastatin calcium SNEDDS to offer the potential for delivery and it increases the aqueous solubility and bioavailability of the drug.

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