FORMULATION AND PHYSICAL CHARACTERIZATION OF CURCUMIN NANOPARTICLE TRANSDERMAL PATCH

SURYANI; W. A. ODE SITTI MUSNINA; RUSLIN; MICHRUN NISA; RIMA APRIANTI; MARGANITA HASANAH; FIRDA RAHMANIA PUTRI; ANDI NAFISAH TENDRI ADJENG; NANI YUNIAR; MUHAMAD HANDOYO SAHUMENA; MUHAMMAD  ASWAN

doi:10.22159/ijap.2019v11i6.34780

Authors

SURYANI Department of Pharmacy, Faculty of Pharmacy, Halu Oleo University, Kendari, Sulawesi Tenggara, Indonesia
W. A. ODE SITTI MUSNINA Department of Pharmacy, Faculty of Mathematics and Science, Tadulako University, Palu, Sulawesi Tengah, Indonesia
RUSLIN Department of Pharmacy, Faculty of Pharmacy, Halu Oleo University, Kendari, Sulawesi Tenggara, Indonesia
MICHRUN NISA Sekolah Tinggi Ilmu Farmasi, Makassar, Sulawesi Selatan, Indonesia
RIMA APRIANTI Department of Pharmacy, Faculty of Pharmacy, Halu Oleo University, Kendari, Sulawesi Tenggara, Indonesia
MARGANITA HASANAH Department of Pharmacy, Faculty of Pharmacy, Halu Oleo University, Kendari, Sulawesi Tenggara, Indonesia
FIRDA RAHMANIA PUTRI Department of Pharmacy, Faculty of Pharmacy, Halu Oleo University, Kendari, Sulawesi Tenggara, Indonesia
ANDI NAFISAH TENDRI ADJENG Department of Pharmacy, Faculty of Pharmacy, Halu Oleo University, Kendari, Sulawesi Tenggara, Indonesia
NANI YUNIAR Faculty of Public Health, Halu Oleo University, Kendari, Sulawesi Tenggara
MUHAMAD HANDOYO SAHUMENA Department of Pharmacy, Faculty of Pharmacy, Halu Oleo University, Kendari, Sulawesi Tenggara, Indonesia
MUHAMMAD ASWAN Department of Pharmacy, Faculty of Pharmacy, Halu Oleo University, Kendari, Sulawesi Tenggara, Indonesia

DOI:

https://doi.org/10.22159/ijap.2019v11i6.34780

Keywords:

Formulation, Physical characterization, Curcumin Nanoparticles, Transdermal patch

Abstract

Objective: This study was conducted to formulate curcumin nanoparticles transdermal patches and to evaluate their physical characterization.

Methods: Curcumin nanoparticles transdermal patches were formulated by the casting evaporation method. Transdermal patches were made using combinations of hydroxypropyl methylcellulose (HPMC) and ethyl cellulose (EC) at ratios of 4.5:1.5 for Formula 1 (F1), 4:1 for Formula 2 (F2), 3.5:1.5 for Formula 3 (F3), 3:2 for Formula 4 (F4), and 2.5:2.5 for Formula 5 (F5). Physical characterization evaluation (organoleptic properties, pH, weight uniformity, thickness uniformity, percent moisture content, and tensile strength) was then performed. The permeation of curcumin nanoparticles into the skin was evaluated using Franz diffusion cells.

Results: Curcumin nanoparticles transdermal patches could be formulated by the casting evaporation method with the organoleptic properties characterized as smooth, dry, yellow in color, having menthol odor, and transparent. The pH values ranged between 5.0 and 6.0. The thickness of the patches ranged from 0.1 to 0.2 mm. The average of the patches’ weight was 0.7 g, and the percent moisture content ranged from 1.0 to 6.0%. The tensile strength values were 1.0 to 2.0 N/mm. Curcumin nanoparticles could penetrate into the skin with flux values being 1.271 µg. cm^-2 (F1), 0.938 µg. cm^-2 (F2), 0.775 µg. cm^-2 (F3), 0.837 µg. cm^-2 (F4), and 0.569 µg. cm^-2 (F5).

Conclusion: All patches met the requirement of the physical characterization for the transdermal patch.

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