DESIGN AND CHARACTERIZATION OF CANDESARTAN CILEXETIL ORAL NANOEMULSION CONTAINING GARLIC OIL

ABULFADHEL JABER NEAMAH  AL-SHAIBANI; KARRAR MOHAMMED HASAN  AL-GBURI; KARRAR TALIB KHUDHAIR  ALBO HAMRAHA; ALI MOHAMMED ABD ALRIDHA

doi:10.22159/ijap.2019v11i6.35066

Authors

ABULFADHEL JABER NEAMAH AL-SHAIBANI Department of Pharmaceutics, Faculty of Pharmacy, University of Kufa, Najaf, Iraq
KARRAR MOHAMMED HASAN AL-GBURI Department of Clinical Pharmacy, Faculty of Pharmacy, University of Kufa, Najaf, Iraq https://orcid.org/0000-0003-1162-5789
KARRAR TALIB KHUDHAIR ALBO HAMRAHA Department of Pharmaceutics, Faculty of Pharmacy, University of Kufa, Najaf, Iraq
ALI MOHAMMED ABD ALRIDHA Department of Clinical Pharmacy, Faculty of Pharmacy, University of Kufa, Najaf, Iraq

DOI:

https://doi.org/10.22159/ijap.2019v11i6.35066

Keywords:

Oral Nanoemulsion, Pseudo-ternary phase diagram, Biopharmaceutics classification system (BCS), Candesartan cilexetil, Solubility

Abstract

Objective: This study was designed to prepare and characterize oil in water (o/w) nanoemulsion of candesartan cilexetil for oral administration. Preparation of candesartan cilexetil as nanoemulsion could increase its water solubility and thus could enhance its bioavailability.

Methods: Aqueous titration method was used to construct the pseudo-ternary phase diagrams of nanoemulsion (NE) consisting of oil, various weight ratios of surfactant and co-surfactant (S mix), and deionized water. Different characterization techniques were conducted on the prepared nanoemulsions to obtain the optimized formula.

Results: Characterizations of formula NE-4 (consists of 0.16% of candesartan cilexetil, 10% of garlic oil, 35 % of S mix (3:1) and 54.84% of deionized water) revealed the following characteristics: droplet size range (95-139 nm), polydispersity index (0.14), zeta potential value (-41.06 mV) and pH value (6.71), which are suitable for oral administration. Candesartan cilexetil in vitro release from this formula was significantly high (P<0.05) and scanning probe microscopy (SPM) study confirmed that the optimized formula (NE-4) was in nano-scale.

Conclusion: Nanoemulsion formula 4 (NE-4) of candesartan cilexetil is the optimized formula and it could be a promising formula for improving the water solubility of candesartan cilaxetil.

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