IMPROVEMENT OF SIMVASTATIN DISSOLUTION RATE USING DERIVATIVE NON-COVALENT APPROACH BY SOLVENT DROP GRINDING METHOD

IYAN  SOPYAN; INSAN SUNAN KURNIWAN  SYAH; DESI  NURHAYTI; ARIF  BUDIMAN

doi:10.22159/ijap.2020v12i1.35865

Authors

IYAN SOPYAN Departement of pharmaceutics and Technology of Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Pusdi Drug Delivery and Disposition, Faculty of Pharmacy, Universitas Padjadjaran, Bandung, Indonesia
INSAN SUNAN KURNIWAN SYAH Departement of Pharmaceutics and Technology of Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Bandung, Indonesia
DESI NURHAYTI Departement of Pharmaceutics and Technology of Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Bandung, Indonesia
ARIF BUDIMAN Departement of Pharmaceutics and Technology of Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Bandung, Indonesia

DOI:

https://doi.org/10.22159/ijap.2020v12i1.35865

Keywords:

Simvastatin, Non-covalent derivative, Solvent drop grinding, Dissolution

Abstract

Objective: This study aimed to enhance the solubility of simvastatin using noncovalent derivatives (NCDs) with oxalic acid (OA), fumaric acid (AF), and nicotinamide (NK) as conformers.

Methods: NCDs were prepared using by a solvent drop grinding (SDG). The NCDs formed were evaluated for saturated solubility test, NCDs with the highest saturation solubility were then characterized by Fourier transform infrared spectrophotometry (FT-IR), differential scanning calorimeter (DSC), powder x-ray diffractometry (PXRD) and the particulate dissolution using type II of USP test.

Results: SV-OA NCDs showed the highest solubility; thus NCDS of SV-OA were characterized by X-ray diffraction showing a new peak at 2ϴ = 28.96 °C and differential scanning calorimeter showed a change of endothermic peak from 134.3 °C to 69 °C. Infrared spectroscopy indicated that there were no functional group changes from simvastatin, while the dissolution rate increased from 68.22% to 76.08%.

Conclusion: SV-OA NCDs show an increased profile of solubility and dissolution compared to pure simvastatin.

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Author Biography

IYAN SOPYAN, Departement of pharmaceutics and Technology of Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Pusdi Drug Delivery and Disposition, Faculty of Pharmacy, Universitas Padjadjaran, Bandung, Indonesia

Department of pharmaceutics and technology of pharmacy

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