FORMULATION AND IN VITRO SKIN PENETRATION OF A SOLID LIPID NANOPARTICLE GEL CONTAINING COFFEA ARABICA EXTRACT

JIHAN AGEIS; HERMAN SURYADI; MAHDI JUFRI

doi:10.22159/ijap.2020.v12s1.FF040

Authors

JIHAN AGEIS Laboratory of Pharmaceutics and Pharmaceutical Technology Development, Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia
HERMAN SURYADI Laboratory of Pharmaceutics and Pharmaceutical Technology Development, Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia
MAHDI JUFRI Laboratory of Pharmaceutics and Pharmaceutical Technology Development, Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia

DOI:

https://doi.org/10.22159/ijap.2020.v12s1.FF040

Keywords:

Coffea arabica, Microwave-assisted extraction, Solid lipid nanoparticle, Gel, Solid lipid nanoparticle gel, Physical stability

Abstract

Objective: The extract of Coffea contains caffeine that could be used for its anticellulite activity. This study aimed to formulate a Coffea arabica
grounds residue extract into a solid lipid nanoparticles (SLNs) gel dosage form and examine the physical stability and in vitro skin penetration of the
formulation.
Methods: Coffee grounds residue (CGR) extracts were made into three SLN formulations with different glycerin monostearate (GMS) concentrations
of 1%, 2%, and 3%. The SLN F2 formulation was a gel created by high-pressure homogenization (HPH). The in vitro penetration assessed using Franz
diffusion cells and the physical stability of the SLN extract gels was compared with those of the nonsense extract gel.
Results: Formulation F2 with 2% GMS had a mean particle size (PS) of 60.3 nm, a polydispersity index (PDI) of 0.278, and zeta potential of −32±1.40.
The PS for the SLN gel after HPH was 159 nm and the PDI was 0.211. Cycling and mechanical tests showed that the SLN gel was physically stable. The
cumulative amount of caffeine penetrated in vitro was 5.55±0.08 for the CGR-SLN gel and 4.18±0.08 for the CGR gel.
Conclusions: The amount of caffeine penetrated into rat skin was greater for the CGR-SLN gel than for the CGR gel.

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