RELATIONSHIP OF METHYL MERCAPTAN AND HYDROGEN SULFIDE LEVELS WITH TANNERELLA FORSYTHIA QUANTITY IN PERIODONTITIS PATIENTS WITH HALITOSIS AND DIABETES MELLITUS

ADINDA R FITRIA; YUNIARTI SOEROSO; NATALINA; DICKY L TAHAPARY; BOY M BACHTIAR

doi:10.22159/ijap.2020.v12s2.OP-59

Authors

ADINDA R FITRIA Periodontics Residency Program, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia.
YUNIARTI SOEROSO Department of Periodontics, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia.
NATALINA Department of Periodontics, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia.
DICKY L TAHAPARY Division of Endocrinology and Metabolism, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia. Metabolic, Cardiovascular and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia.
BOY M BACHTIAR Department of Oral Biology, Faculty of Dentistry, Universitas Indonesia, Jakarta

DOI:

https://doi.org/10.22159/ijap.2020.v12s2.OP-59

Keywords:

Methyl mercaptan, Hydrogen sulfide, Tannerella forsythia, Periodontitis, Halitosis, Diabetes mellitus

Abstract

Objective: Halitosis may be caused by several factors, including various types of food, periodontal diseases, layer of tongue bacteria, and systemic
disorders such as diabetes mellitus (DM), which is a chronic disease that affects the health of periodontal tissue. The present study aimed to assess
the association between the quantity of Tannerella forsythia bacteria and the levels of methyl mercaptan and hydrogen sulfide in periodontitis patients
with type 2 DM (T2DM).
Methods: Gingival crevicular fluids (GCF) were collected from 20 patients who were divided into those with periodontitis and who were normoglycemic
(n=8); those with periodontitis and T2DM (n=8); and healthy controls (n=4). The patients underwent intraoral periodontal tissue examination,
including pocket depth, attachment loss, plaque index, calculus index, and papilla bleeding index. The quantity of T. forsythia bacteria was evaluated
using quantitative real-time reverse transcription–polymerase chain reaction. The relationship between the number of T. forsythia bacteria and the
levels of methyl mercaptan and hydrogen sulfide in the patients was analyzed by Spearman’s correlative tests.
Results: There is a weak and non-significant correlation (p>0.05) between the levels of methyl mercaptan and hydrogen sulfide and the quantity of
T. forsythia in the GCF and tongue coating of periodontitis patients with halitosis regardless of the presence of T2DM.
Conclusion: This study suggests no significant relationship between the levels of methyl mercaptan and hydrogen sulfide and the quantity of
T. forsythia in periodontitis patients with halitosis and DM.

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