REVIEW ON EVALUATING THE ROLE OF NSAIDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE

KRISHNENDU P. R.; ARJUN B.; VIBINA K.; NIVEA CLEO T. S.; DRISYA N. K.; RADHIKA MOHANDAS; SUBIN MARY ZACHARIAH; SUBIN MARY ZACHARIAH

doi:10.22159/ijap.2021v13i1.39928

Authors

KRISHNENDU P. R. Department of Pharmaceutical Chemistry and Analysis, Amrita School of Pharmacy, AIMS Health Sciences Campus, Amrita Vishwa Vidyapeetham, AIMS, Kochi 682041, Kerala, India
ARJUN B. Department of Pharmaceutical Chemistry and Analysis, Amrita School of Pharmacy, AIMS Health Sciences Campus, Amrita Vishwa Vidyapeetham, AIMS, Kochi 682041, Kerala, India
VIBINA K. Department of Pharmaceutical Chemistry and Analysis, Amrita School of Pharmacy, AIMS Health Sciences Campus, Amrita Vishwa Vidyapeetham, AIMS, Kochi 682041, Kerala, India
NIVEA CLEO T. S. Department of Pharmaceutical Chemistry, Lecturer, KMCT College of Pharmaceutical Sciences, Technical Campus, Kallanthode, NITC, Calicut,673601, Kerala, India
DRISYA N. K. Department of Pharmaceutical Chemistry, Lecturer, KMCT College of Pharmaceutical Sciences, Technical Campus, Kallanthode, NITC, Calicut,673601, Kerala, India
RADHIKA MOHANDAS Department of Pharmaceutical Chemistry, Lecturer, Crescent College of Pharmaceutical Science, Madayipara, P O. Payangadi (R. S.), 670358, Kannur, Kerala, India
SUBIN MARY ZACHARIAH Department of Pharmaceutical Chemistry and Analysis, Amrita School of Pharmacy, AIMS Health Sciences Campus, Amrita Vishwa Vidyapeetham, AIMS, Kochi 682041, Kerala, India
SUBIN MARY ZACHARIAH Department of Pharmaceutical Chemistry, Lecturer, Crescent College of Pharmaceutical Science, Madayipara, P O. Payangadi (R. S.), 670358, Kannur, Kerala, India

DOI:

https://doi.org/10.22159/ijap.2021v13i1.39928

Keywords:

Nonsteroidal anti-inflammatory drug, Alzheimer`s disease, Neurodegeneration, Neuroinflammation, COX-1 and COX-2, A Beta

Abstract

Recently, several studies have been reported that nonsteroidal anti-inflammatory drugs can fight against neurodegenerative disorders by various mechanisms. Currently, available therapies of neurodegenerative disorders (NDs) provide only symptomatic relief. This is the point at which we need an alternative that acts on the root cause of disease. Parkinson’s disease and Alzheimer’s disease are the two NDs concentrated here. Since the drug profile is already known, drug repurposing is a promising technique in research, thereby reducing the cost and period effectively. Epidemiological studies on various nonsteroidal anti-inflammatory drugs (NSAIDs) showed good results, but when it came to clinical studies the results are found to be poor. Hence, it can be concluded that NSAIDs provide its neuroprotective activity on its long-term use only, as the brain accessibility of this kind of drug is poor due to its lower lipophilicity.

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