IMPROVEMENT AND ESTIMATION OF ORALLY DISINTEGRATING TABLETS CONTAINING PILOCARPINE 2-HYDROXY PROPYL β-CYCLODEXTRIN INCLUSION COMPLEX BY RESPONSE SURFACE METHODOLOGY

JOGABRATA TRIPATHY; SUBHASHREE SAHOO; AFRASIM MOIN; SIDDARAMAIAH; D. V. GOWDA

doi:10.22159/ijap.2021v13i2.40292

Authors

JOGABRATA TRIPATHY Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education and Research, S. S. Nagara, Mysuru 570015, Karnataka, India
SUBHASHREE SAHOO Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education and Research, S. S. Nagara, Mysuru 570015, Karnataka, India
AFRASIM MOIN Department of Pharmaceutics, College of Pharmacy, University of Hail, PO Box 2440, Hail, Saudi Arabia
SIDDARAMAIAH Department of Polymer Science and Technology, S. J. College of Engineering, JSS Science and Technology University, Mysuru 570006, Karnataka, India
D. V. GOWDA Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education and Research, S. S. Nagara, Mysuru 570015, Karnataka, India

DOI:

https://doi.org/10.22159/ijap.2021v13i2.40292

Keywords:

Pilocarpine, 2-hydroxy propyl Beta-cyclodextrin, Orally disintegrating tablets

Abstract

Objective: The study aimed to develop and evaluate an orally disintegrating tablet that contains pilocarpine and 2-hydroxy propyl β-cyclodextrin as an inclusion complex that is prepared by lyophilization used for treatment for dry mouth. Pilocarpine is utilized to treat dry mouth disorder. The inclusion complex lowers the taste of pilocarpine through the oral mucosa by the use of 2-hydroxy propyl β-cyclodextrin.

Methods: The in vitro release from the insertion complex is also been studied. The parameters like differential scanning calorimetry (DSC), Fourier transformer infrared spectroscopy (FTIR), X-ray diffraction (XRD), and morphological study have been evaluated. The design of an experiment is carried out based on the concentration of croscarmellose sodium (CCS) and microcrystalline cellulose (MCC). Evaluation of the prepared orally disintegrating tablets have been carried out by different test methods like weight variation, thickness, drug content, disintegration, and in vitro dissolution study.

Results: Orally disintegrating tablets are studied by utilizing the immediate pressure technique. Pilocarpine indicates the anhydrous crystalline medication, displaying sharp endothermic top at 120.2 °C, bend of 2-HPβCD demonstrates an exceptionally wide endothermal wonder among 55-100 °C for DSC. In pilocarpine spectra, characteristic band of aromatic C-H stretch at 3277 cm^-1, C=C stretching at 1608 cm^-1, C-N stretching at 1445 cm^-1and methoxy (CH₃-O-) stretch at 2921 cm^-1was observed. The investigation shows that tablet hardness of 4.3N, breaking downtime of 12 sec and mean disintegration time is 1.562 min.

Conclusion: The different diluents and super disintegrating have been applied for the quick elevation of dry mouth that helps us for patient compliance.

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