ANTIPYRETIC ACTIVITY OF CENTELLA (CENTELLA ASIATICA (L.) URBAN) HERB IN VACCINE INDUCED MICE
DOI:
https://doi.org/10.22159/ijap.2021.v13s3.16Keywords:
Centella, Infusion, DPT vaccine, ParacetamolAbstract
Objective: This study aimed to determine the antipyretic activity of the infusion of centella (Centella asiatica (L.) Urban) herb, based on empirically usage of Indonesian people.
Methods: Antipyretic activity assay was conducted to Swiss-Webster mice, which induced by diphtheria-pertussis-tetanus (DPT) vaccine with paracetamol as positive control.
Results: Centella herb was contained tannins, flavonoids, monoterpenoids, sesquiterpenoids, triterpenoids, steroids, and saponins. The antipyretic activity of centella infusion has a ratio 1:44.6, compare to paracetamol.
Conclusion: Antipyretic activity of centella herbs was predicted due to its secondary metabolites.
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References
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2. Jamil SS, Nizami Q, Salam M. Centella asiatica (Linn.) Urban-a review. Nat Prod Radiance 2007;6:158-70.
3. Dalimartha S. Atlas of Indonesian medicinal plants. Vol. II. Jakarta: Trubus Agriwidya; 2000.
4. Wagner H, Norr H, Winterhoff H. Plant adaptogens. Phytomedicine 1994;1:63-76.
5. Somasundaram T, Maheswari KU, Suneetha JW, Prasad TNVKV, Rajeswari B. Screening for plant secondary metabolites in selected indigenous herbal plants. Imperial J Interdisciplinary Res 2016;2:1103-6.
6. Roy DC, Barman SK, Shaik MM. Current updates on Centella asiatica: Phytochemistry, pharmacology and traditional uses. Med Plant Res 2013;3:70-7.
7. Tiwari P, Kumar B, Kaur M, Kaur G, Kaur H. Phytochemical screening and extraction. Int Pharm Sci 2011;1:98-106.
8. Saptarini NM, Deswati DA. The antipyretic activity of leaves extracts of Ceiba pentandra better than Gossypium arboreum. J Appl Pharm Sci 2015;5:118-21.
9. Saptarini NM, Deswita DA. Antipyretic activity of plantain (Plantago major L.) leaves extract in yeast-induced mice. Drug Invention Today 2019;12:1588-90.
10. https://www.cdc.gov/vaccines/hcp/vis/vis-statements/dtap.html [Last accessed on 10 Aug 2020]
11. Dipiro J, Talbert R, Yee G, Matzke G, Wells B, Posey L. Pharmacotherapy: a pathophysiologic approach. New York: The McGraw-Hill Companies Inc; 2008. [Last accessed on 10 Aug 2020]
12. Parganiha R, Verma S, Chandrakar S, Pal S, Sawarkar HA, Kashyap P. In vitro anti-asthmatic activity of fruit extract of Piper nigrum (Piperaceae). Int J Herbal Drug Res 2011;1:15-8.
13. Bhaskar VH, Balakrishnan N. Analgesic, anti-inflammatory and antipyretic activities of Pergularia daemia and Carissa carandas. DARU 2009;17:168-17.
14. Potduang B, Meeploy M, Giwanon R, Benmart Y, Kaewduang M, Supatanakul W, et al. Biological activities of Asparagus racemosus. Afr J Tradit Complement Altern Med 2008;5:230-7.
15. Pendota SC, Yakubu M, Grierson DS, Afolayan AJ. Anti-inflammatory, analgesic and antipyretic activities of the aqueous extract of Hippobromus pauciflorus (Lf) radlk leaves in male wistar rats. Afr J Biotechnol 2009;8:2036-41.
16. Taiwe GS, Bum EN, Dimo T, Talla E, Sidiki NW, Dawe A, et al. Antipyretic and antinociceptive effects of Nauclea latifolia roots decoction and possible mechanisms of action. Pharm Biol 2011;49:15-25.
17. Adesokan AA, Yakubu MT, Owoyele BV, Akanji MA, Soladoye AO, Lawal O. Effect of administration of aqueous and ethanol extracts of Enantia chlorantha stem bark on brewer’s yeast induced pyresis in rats. Afr J Biochem 2008;2:165-9.
18. Dillard GM, Bodel P. Studies on steroid fever. II. Pyrogenic and anti-pyrogenic activity in vitro of some endogenous steroids of man. J Clin Invest 1970;49:2418-26.
Published
10-03-2021
How to Cite
SAPTARINI, N. M., & KARTIKAWATI, E. (2021). ANTIPYRETIC ACTIVITY OF CENTELLA (CENTELLA ASIATICA (L.) URBAN) HERB IN VACCINE INDUCED MICE. International Journal of Applied Pharmaceutics, 13(3), 76–78. https://doi.org/10.22159/ijap.2021.v13s3.16
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