ANTI-ACNE CREAM OF LEAVES EXTRACT OF FIG (FICUS CARICA L.) FROM CIWIDEY DISTRICT, INDONESIA, AGAINST PROPIONIBACTERIUM ACNES AND STAPHYLOCOCCUS EPIDERMIDIS

Authors

  • NYI MEKAR SAPTARINI Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran-45363, West Java, Indonesia
  • DIAH LIA AULIFA Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran-45363, West Java, Indonesia
  • RESMI MUSTARICHIE Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran-45363, West Java, Indonesia
  • RINI HENDRIANI Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran-45363, West Java, Indonesia
  • IRMA ERIKA HERAWATI Indonesian School of Pharmacy, West Java-40266, Indonesia
  • MARY JHO-ANNE T. CORPUZ Department of Pharmacy, Faculty of Pharmacy, University of Santo Tomas, Espana-1015, Manila, Philippines

DOI:

https://doi.org/10.22159/ijap.2023.v15s2.27

Keywords:

Fig leaves extract, P. acnes, S. epidermidis, Safe cream, Dose-dependent

Abstract

Objective: This study aimed to formulate and evaluate an anti-acne cream of fig leaves extract.

Methods: The methods included formulation and evaluation of anti-acne cream, antibacterial activity assay against Propionibacterium acnes and Staphylococcus epidermidis, irritancy test, and preference test. The oil-in-water creams were made with various extract concentrations (1, 2, and 3%).

Results: Greenish cream with fig fragrant, viscosity ranging from 332 to 388 cP, pH ranging from 6.69 to 7.23, and oil-in-water type. Antibacterial activity was dose-dependent, without irritancy, erythema, and edema, and the most preferred cream based on the texture and fragrance was the 3% extract formula.

Conclusion: Fig leaves extract can be made into a safe cream with antibacterial activity against P. acnes and S. epidermidis.

Downloads

Download data is not yet available.

References

Wong M. Ficus plants for Hawai’i landscapes. Ornamentals Flowers. 2007;34:1-13.

Saptarini NM, Pratiwi R, Maisyarah IT. Colorimetric method for total phenolic and flavonoid content determination of fig (Ficus carica L.) leaves extract from west Java, Indonesia. Rasayan J Chem. 2022;15(1):6000-605. doi: 10.31788/RJC.2022.1516670.

Saptarini NM, Mustarichie R, Aulifa DL, Hendriani R, Herawati IE. Analysis of antioxidant and antibacterial activity of leaves of fig (Ficus carica l.) from Ciwidey District. Rasayan J Chem. 2022;Special Issue:172-9.

Duke JA, Bugenschutz Godwin MJ, Du Collier J, Duke PK. Handbook of medicinal herbs. 2nd ed. Boca Raton: CRC Press; 2002. p. 300-1.

Aydemir EH. Acne vulgaris. Turk Pediatri Ars. 2014;49(1):13-6. doi: 10.5152/tpa.2014.1943.

Otto M. Staphylococcus epidermidis-the ‘accidental’ pathogen. Nat Rev Microbiol. 2009;7(8):555-67. doi: 10.1038/nrmicro2182.

Moloney MG. Natural products as a source for novel antibiotics. Trends Pharmacol Sci. 2016;37(8):689-701. doi: 10.1016/j.tips.2016.05.001.

Moreira DdL, Teixeira SS, Monteiro MHD, De-Oliveira ACAX, Paumgartten FJR. Traditional use and safety of herbal medicine. Revista Brasileira de Farmacognosia. 2014;24(2):248-57. doi: 10.1016/j.bjp.2014.03.006.

Pradhan N, Gavali J, Waghmare N. WHO (World Health Organization) guidelines for standardization of herbal drugs. IAMJ. 2015;3(1):2238-43.

Saptarini NM, Hadisoebroto G. Formulation and evaluation of lotion and cream of nanosized chitosan-mangosteen (Garcinia mangostana L.) pericarp extract. Rasayan J Chem. 2020;13(2):789-95. doi: 10.31788/RJC.2020.1325533.

Mc Mullen RL, Gorcea M, Chen S. Emulsion and their characterization by texture profile analysis. In: Dayan N, editor. Handbook of formulating dermal application. Canada, USA: Scrivener Publishing; 2017. p. 131-55.

Haley S. Methylparaben. In: Rowe RC, Sheskey PJ, editors PJ, Quinn ME (Eds). Handbook of pharmaceutical excipients. 6th ed. Pharmaceutical Press and Washington: American Pharmacists Association; 2009. p. 754-5.

Goskonda SR. Triethanolamine. In: Rowe RC, Sheskey PJ, editors PJ, Quinn ME (Eds). Handbook of pharmaceutical excipients. 6th ed. Pharmaceutical Press and Washington: American Pharmacists Association; 2009. p. 441-5.

Fluhr JW, Elias PM. Stratum corneum pH: formation and Function of the ‘Acid Mantle’. Exog Dermatol. 2002;1(4):163-75. doi: 10.1159/000066140.

Berderly D. Viscosity measurement for topically applied formulations. In: Dayan N, editor. Handbook of formulating dermal application. Canada, USA: Scrivener Publishing; 2017. p. 349-69.

Djiobie Tchienou G, Tsatsop Tsague R, Mbam Pega T, Bama V, Bamseck A, Dongmo Sokeng S. Multi-response optimization in the formulation of a topical cream from natural ingredients. Cosmetics. 2018;5(1):7-14. doi: 10.3390/cosmetics5010007.

Acne. Available from: https://www.verywellhealth.com/acne-overview-4581760. [Last accessed on 31 Aug 2023]

Published

18-12-2023

How to Cite

SAPTARINI, N. M., AULIFA, D. L., MUSTARICHIE, R., HENDRIANI, R., HERAWATI, I. E., & CORPUZ, M. J.-A. T. (2023). ANTI-ACNE CREAM OF LEAVES EXTRACT OF FIG (FICUS CARICA L.) FROM CIWIDEY DISTRICT, INDONESIA, AGAINST PROPIONIBACTERIUM ACNES AND STAPHYLOCOCCUS EPIDERMIDIS. International Journal of Applied Pharmaceutics, 15(2), 145–148. https://doi.org/10.22159/ijap.2023.v15s2.27

Issue

Section

Original Article(s)

Most read articles by the same author(s)

1 2 3 > >>