EFFECT OF STERILIZATION USING GAMMA RADIATION ON THE PHYSICOCHEMICAL PROPERTIES OF GEL CONTAINING ALOE VERA POWDER

Authors

  • ARIF BUDIMAN Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Jl. Raya Bandung Sumedang Km 21, Indonesia

DOI:

https://doi.org/10.22159/ijap.2021v13i4.41771

Keywords:

Gamma radiation, Gel, Aloe vera

Abstract

Objective: This study aims to prepare sterile gel containing aloe vera (AV) powder and evaluate its physicochemical properties after sterilization by gamma radiation.

Methods: The gel was prepared using carbomer as stabilizer, and sterilized by gamma radiation. The physical stability was evaluated including organoleptic, pH, viscosity and sterilization. Furthermore, malic acid concentration was determined as a marker compound contained in the gel.

Results: The gel was successfully prepared containing 20% AV powder and 25% carbomer. The physical properties including organoleptic, pH and viscosity were not significantly changed after sterilization, and also stable even after 28 storage days. Meanwhile, malic acid concentration before and after sterilization were 47.2 mg/ml and 43.9 mg/ml, respectively. This showed the physicochemical properties were not significantly different after sterilization.

Conclusion: Gamma radiation is suitable to sterilize gel containing AV powder.

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References

Ahmed EM. Hydrogel: preparation, characterization, and applications: a review. J Adv Res 2015;6:105-21.

Lugao AB, Rogero SO, Malmonge SM. Rheological behaviour of irradiated wound dressing poly (vinyl pyrrolidone) hydrogels. Radiat Phys Chem 2002;63:543-6.

Chatterjee S, Hui PC, Kan CW. Thermoresponsive hydrogels and their biomedical applications: Special insight into their applications in textile based transdermal therapy. Polymers 2018;10:480.

Zanon D, Volpato C, Addobbati R, Loiacono S, Maestro A, Barbi E, et al. Stability of a novel lidocaine, adrenaline and tetracaine sterile thermosensitive gel: a ready-to-use formulation. Eur J Pharm Sci 2019;136:104962.

Anurova MN, Bakhrushina EO, Demina NB. Review of contemporary gel-forming agents in the technology of dosage forms. Pharm Chem J 2015;49:627-34.

Rabiskova M, Sedlakova M, Vitkova M, Kuna M. Carbomers and their use in pharmaceutical technology. Ceska Slov Farm Ces Slov Far Cesk Farm Cesk Farm 2004;53:300-3.

Gad SC. Pharmaceutical manufacturing handbook production and processes north carolina. New Jersey: John Wiley and Sons Inc; 2008.

Niazi SK. Handbook of pharmaceutical manu-facturing formulations. Part II. Formulations of Semisolid Drugs. Florida: CRC Press LLC; 2004.

Silindir M, Ozer AY. Sterilization methods and the comparison of E-beam sterilization with gamma radiation sterilization. Fabad J Pharm Sci 2009;34:43.

Reid BD. Gamma processing technology: an alternative technology for terminal sterilization of parenterals. PDA J Pharm Sci Tech 1995;49:83-9.

Olguner G, Ozer AY. Radyasyonla sterilizasyon II: Ilacların radyasyonla sterilizasyonu. FABAD J Pharm Sci 2000;25:53-73.

Higashi N, Yokota H, Hiraki S, Ozaki Y. Direct determination of peracetic acid, hydrogen peroxide, and acetic acid in disinfectant solutions by far-ultraviolet absorbtion spectroscopy. Anal Chem 2005;77:2272-7.

Maquille A, Slegers C, Habib JL, Tilquin B. Electron beam and gamma radiolysis of solid-state metoclopramide. Pharm Res 2006;23:1343-9.

Boyd C. E-beam sterilizes the industry. J Student Res 2002;1:39-43.

Huq T, Khan A, Dussault D, Salmieri S, Khan RA, Lacroix M. Effect of gamma radiation on the physico-chemical properties of alginate-based films and beads. Radiat Phys Chem 2012;81:945-8.

Bozzi A, Perrin C, Austin S, Vera FA. Quality and authenticity of commercial aloe vera gel powders. Food Chem 2007;103:22-30.

Budiman A, Khoerunnisa R, Qoriah TA. Wound-healing test of Piper betle leaf extract and aloe vera in gel preparation. Int J Appl Pharm 2018;10:86-91.

Islam MT, Rodriguez Hornedo N, Ciotti S, Ackermann C. Rheological characterization of topical carbomer gels neutralized to different pH. Pharm Res 2004;21:1192-9.

Mukherjee D, Banthia AK. Preparation of adrenochrome hydrogel patch, gel, ointment, and the comparison of their blood coagulating and wound healing capability. Mater Manuf Process 2006;21:297-301.

Patil PM, Wankhede SB, Chaudhari PD. Stability-indicating HPTLC method for simultaneous determination of Ketoprofen, methyl paraben and propyl paraben in gel formulation. J Pharm Res 2013;6:945-53.

Dotto SR, Travassos RMC, De Oliveira EPM, de Lima Machado ME, Martins JL. Evaluation of ethylenediaminetetraacetic acid (EDTA) solution and gel for smear layer removal. Aust Dent J 2007;33:62-5.

Maia AM, Baby AR, Pinto CA, Yasaka WJ, Suenaga E, Kaneko TM, Velasco MVR. Influence of sodium metabisulfite and glutathione on the stability of vitamin C in O/W emulsion and extemporaneous aqueous gel. Int J Pharm 2006;322:130-5.

Byun EH, Kim JH, Sung NY, Choi JI, Lim ST, Kim KH, et al. Effects of gamma irradiation on the physical and structural properties of β-glucan. Radiat Phys Chem 2008;77:781-6.

Ajji Z, Othman I, Rosiak JM. Production of hydrogel wound dressings using gamma radiation. Nucl Instrum Methods Phys Res B 2005;229:375-80.

Kim KH, Lee JG, Gyuun D, Kim MK, Park JH, Shin YG, et al. The development of a new method to detect the adulteration of commercial aloe gel powders. Arch Pharm Res 1998;21:514-20.

Jiao P, Jia Q, Randel G, Diehl B, Weaver S, Milligan G. Quantitative 1H-NMR spectrometry method for quality control of Aloe vera products. J AOAC Int 2010;93:842-8.

Garcia MJ, Zuniga M, Kobayashi H. Energy production from L-malic acid degradation and protection against acidic external pH in lactobacillus plantarum CECT 220. Microbiology 1992;138:2519-24.

Raybaudi Massilia RM, Mosqueda Melgar J, Martin Belloso O. Edible alginate-based coating as carrier of antimicrobials to improve shelf-life and safety of fresh-cut melon. Int J Food Microbiol 2008;121:313-27.

Pelley RP, Wang YT, Waller TA. Current status of quality control of Aloe barbadensis extracts. Seifen Ole Fette Wachse 1993;119:255.

Kumar S, Yadav M, Yadav A, Yadav JP. Molecular assessment of genetic diversity in Indian accessions of Aloe vera using SSR marker. Int J Pharm Pharm Sci 2015;7:149-54.

Published

07-07-2021

How to Cite

BUDIMAN, A. (2021). EFFECT OF STERILIZATION USING GAMMA RADIATION ON THE PHYSICOCHEMICAL PROPERTIES OF GEL CONTAINING ALOE VERA POWDER. International Journal of Applied Pharmaceutics, 13(4), 282–285. https://doi.org/10.22159/ijap.2021v13i4.41771

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Section

Short Communication(s)