DISCOSOMES: A FUTURISTIC UPHEAVAL IN VESICULAR DRUG DELIVERY

AMITHA MARY JOSE; V. U. LAKSHMI; GAYATHRI S.; SREEJA C. NAIR

doi:10.22159/ijap.2021v13i6.42008

Authors

AMITHA MARY JOSE Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, Aims Health Sciences Campus, Kochi 682041, Kerala, India
V. U. LAKSHMI Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, Aims Health Sciences Campus, Kochi 682041, Kerala, India
GAYATHRI S. Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, Aims Health Sciences Campus, Kochi 682041, Kerala, India
SREEJA C. NAIR Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, Aims Health Sciences Campus, Kochi 682041, Kerala, India

DOI:

https://doi.org/10.22159/ijap.2021v13i6.42008

Keywords:

Discosomes, Novel drug delivery, Disc-shaped, Giant niosomes, Non-ionic surfactant, Ophthalmic, Cul-de-sac

Abstract

The formulation system employed to convey pharmaceutical drugs compound in the body to attain the desired therapeutic effect at a predetermined rate depending on pharmacological aspects, drug profile, and physiological conditions can be referred to as a novel drug delivery system (NDDS). Due to the intricately sensitive anatomy and physiology of the eye pharmacologist find the ocular delivery system to be more involuted than other routes. Pre-corneal, static and dynamic is the 3 types of ophthalmic barriers, which along with the inflow and outflow of lacrimal fluids, nasolacrimal drainage, are some of the germane factors that affect bioavailability. Unlike conventional dosage forms, where the distribution of drugs in non-targeted body fluids and tissues transcends the quantity of required drug in targeted tissues and causes repercussions, these modified drug delivery systems surpass the ocular barriers and adverse reactions, emphasizing on less invasive, prolonged action. It also promotes sustained release formulation that subjugates the drug loss or degradation to treat many ocular diseases effectively. The current review recapitulates the fundamentals of discosomes, a type of vesicular drug delivery system that acts as a vehicle for the drug delivery of both hydrophilic and lipophilic drugs. Discosomes are giant, disc-shaped structures modified from niosomes by arresting the vesicles at the discosome phase. Due to their idiosyncratic size, it provides all due benefits compared to other ocular drug delivery systems. From the review, it can be culminated that discosomes are a potential subject of opposition and opportunities in the arena of safe and effective ocular drug delivery.

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