CHARACTERISTICS OF EUGENOL PRODUCTS AND IN VITRO RELEASE IN GEL BASE WITH HYDROXYPROPYL METHYLCELLULOSE (HPMC) VARIANT AS GELLING AGENT

SHOLICHAH ROHMANI; ADI YUGATAMA; ISTI WIJAYANTI; DIAN EKA ERMAWATI; ANIF NUR ARTANTI; WISNU KUNDARTO; M. FIQRI ZULPADLY

doi:10.22159/ijap.2021v13i6.42351

Authors

SHOLICHAH ROHMANI Department of Pharmacy, Pharmacy Diploma Study Program, Vocational School, Sebelas Maret University, Surakarta, Indonesia
ADI YUGATAMA Department of Pharmacy, Bachelor of Pharmacy Study Program, Faculty of Mathematics and Natural Sciences, Sebelas Maret University, Surakarta, Indonesia
ISTI WIJAYANTI Department of Pharmacy, Bachelor of Pharmacy Study Program, Faculty of Mathematics and Natural Sciences, Sebelas Maret University, Surakarta, Indonesia
DIAN EKA ERMAWATI Department of Pharmacy, Pharmacy Diploma Study Program, Vocational School, Sebelas Maret University, Surakarta, Indonesia
ANIF NUR ARTANTI Department of Pharmacy, Pharmacy Diploma Study Program, Vocational School, Sebelas Maret University, Surakarta, Indonesia
WISNU KUNDARTO Department of Pharmacy, Pharmacy Diploma Study Program, Vocational School, Sebelas Maret University, Surakarta, Indonesia
M. FIQRI ZULPADLY Department of Pharmacy, Pharmacy Diploma Study Program, Vocational School, Sebelas Maret University, Surakarta, Indonesia

DOI:

https://doi.org/10.22159/ijap.2021v13i6.42351

Keywords:

Eugenol, Gel, Hydroxypropyl methylcellulose, Release profile

Abstract

Objective: This research was conducted to examine the characteristics of the eugenol gel preparation in the Hydroxypropyl Methylcellulose (HPMC) gel base and to determine the profile of the release of eugenol from the HPMC gel base.

Methods: Eugenol was made into gel preparations using HPMC base with concentrations of 3%, 5% and 7%. The evaluation included the tests of product characteristic and eugenol release. The product characteristic test included organoleptic examination (texture, color, and odor) and tests of spreadability, adhesion, and pH. The release test was carried out using cell diffusion and cellophane membranes.

Results: All formulas met the pH requirements of topical products that were safe to use. The spreadability test is between 2.97-6.27 cm, adhesion test of products>4 s. The percentage of determination of eugenol content in the gel formula (F1 105.81%), (F2 93.28%) and (F3 98.87%). The cumulative amount of eugenol was F1 (2.563 mg/cm2), F2 (2.224 mg/cm2), and F3 (1.895 mg/cm2).

Conclusion: The variation of HPMC as a gel base has effects on the adhesion, spreadability, and the eugenol gel release profile, where the greater the HPMC concentration, the smaller the spreadability, the greater the adhesion, and the lower the eugenol release profile. Based on the data obtained, the Formula 1 had a better release rate.

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References

Daniel AN, Sartoretto SM, Schmidt G, Caparroz-Assef SM, Bersani-Amado CA, Cuman RKN. Anti-inflammatory and antinociceptive activities A of eugenol essential oil in experimental animal models. Rev Bras Farmacogn 2009;19(1b):212-7. doi: 10.1590/S0102-695X2009000200006.

Madan J, Singh R. Formulation and evaluation of Aloe vera topical gels. Int J Phys Sci. 2010;2:551-5.

Arikaumala J, Dewantara IGNA, Wijayanti NPAD. HPMC Optimization as gelling agent in the gel formula of mangosteen peel extract (Garcinia mangostan L.). Udayana J Pharm 2013;2:145-51.

Martin A, Swarbrick J, Cammarata A. Physical pharmacy. 2nd. Yoshita. Jakarta: UI Press; 2012.

Prabawati CA, editor. Evaluation of penetration power of ethyl P-methoxynamate isolation of Kencur rhizome (Kaempheria galanga L) in ointment, cream and gel preparations [thesis]; 2015.

Martin A, Swarbrick J, Cammarata A. Physical pharmacy: list of fundamentals of physical. J Chem Pharm Sci 1993.

Jyothi D, Koland M. Formulation and evaluation of an herbal anti-inflammatory gel containing Trigonella foenum greacum seed extract. Int J Pharm Pharm Sci. 2016;8:41-4.

Patwardhan SK, Bhide MA. Evaluation of myristica fragrans as a penetration enhancer in transdermal gel formulation. Int J Pharm Pharm Sci. 2015;7:350-5.

Adnan J. Leaf extract gel formulation (PluceaindicaLess) with Na-CMC as a gel base. J Pharma Sci Herbal Tech. 2017;1:41-4.

Gallery TI, Astuti DS, Barlian AA. Effect of CMC Na base type on physical quality of Aloe vera extract gel (Aloe vera L.). Pharm Sci;J2016(4):25-9.

Ramadon D, Pramesti SS, Anwar E. Formulation, stability tformulation, stability test and in vitro penetration study of transethosomal gel containing green tea (camellia sinensis l. kuntze) leaves extractest and in vitro penetration study of transethosomal gel containing green tea(camellia sinensis l. kuntze) leaves extract. Int J App Pharm. 2017;9(5):91-6. doi: 10.22159/ijap.2017v9i5.20073.

Tranggono RI, Latifah F, editors. Handbook of cosmetic science. Jakarta: P T. Gramedia Pustaka Utama; 2007.

Elfasyari TY, Putri LR, Wulandari S. Formulation and evaluation of antioxidant gel formulated from jujube (Ziziphus jujuba Mill.) leaves extract. Pharm J Indones. 2019;16:278-85.

Rachmalia NIM, Nining S, Tedjo Y. Irritation and physical properties of clove flower (Syzigium Aromaticum) essential oil ointment on hydrocarbon base. Pharm Mag. 2016;12:372-6.

Karsheva M, Georgieva S, Handjieva S. The choice of the thickener-A way to improve the cosmetics sensory properties. J Univ Chem Technol Metall. 2007;42:187-94.

Nurlaela E, Sugihartini N, Ikhsanudin A. Optimization of the composition of Tween 80 and Span 80 as emulsifiers in the essential oil repellant of Sere leaves (Cymbopogon citratus (D.) Stapf) against female Aedes aegypti mosquitoes on the basis of vanishing cream with the simplex lattice design method. Pharmacy. 2012;2:41-54.

Chan CC, Lee YC, Lam H, Zhang XM, editors. Analytical method validation and instrument performance verification. NJ: Wiley; 2004.

Anonymous. AOAC peer verified methods program, manual on policies and procedure. USA: AOAC International. Rockville; 1998.

Voight R. Pharmaceutical technology textbook. 5nd trans. Noerono. Yogyakarta: Gadjah Mada University Press; 1994.

Boddu R, Vadla HC, Prathap VR, Kothamasu U, Rallabandi BC, Gannu R. Development of an in vitro-in vivo correlation for sitagliptin and metformin prolonged-release tablet formulations. Turk J Pharm Sci. 2021;18(2):233-41. doi: 10.4274/tjps.galenos.2020.60863, PMID 33902269.