MEDICINAL HERBS USED IN MANAGEMENT OF MALARIA IN PAMOTAN VILLAGE COMMUNITY, KALIPUCANG DISTRICT, PANGANDARAN REGENCY, WEST JAVA, INDONESIA

Authors

  • AMI TJITRARESMI Faculty of Pharmacy, Universitas Padjadjaran, Jl. Raya Bandung Sumedang Km 21, Jatinangor, Sumedang 45363
  • MOELYONO MOEKTIWARDOYO Faculty of Pharmacy, Universitas Padjadjaran, Jl. Raya Bandung Sumedang Km 21, Jatinangor, Sumedang 45363
  • YASMIWAR SUSILAWATI Faculty of Pharmacy, Universitas Padjadjaran, Jl. Raya Bandung Sumedang Km 21, Jatinangor, Sumedang 45363

DOI:

https://doi.org/10.22159/ijap.2021.v13s4.43816

Keywords:

Ethnopharmacology, Pamotan village, Antimalarial herbs

Abstract

The aim of this study was to investigate medicinal plants used to treat malaria by a society in Pamotan village, Pangandaran Regency, West Java Province, Indonesia. The work was conducted using the Participatory Rural Appraisal (PRA) method, which is an assessment process-oriented to active community involvement in the form of direct interview activities. Information was collected by interviewing respondents using a semi-structured questionnaire. Interviews were directed to the plants used to prevent and overcome malaria by referring to the list of questions which included the local name of the plant, the part used and the method of preparation and administration. A total of 47 respondents were interviewed of which 43% were females and 57% males. Results indicated that thirteen species of plants belonging were used to treat malaria by the villagers of Pamotan. The three plants that have the highest citation frequency are bitter herbs (Andrographis paniculata Ness.) 35.71%, papaya leaves (Carica papaya L.) 21.43%, and cut leaf ground cherry whole plants (Physalis angulata L.) 21.43%. The most common preparation method is decoction and the route of administration is oral. It is concluded that the Pamotan villagers in Pangandaran district, Indonesia, still use ingredients from plants as complementary medicine to treat malaria.

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References

Kajfasz P. Malaria prevention. Int Marit Health. 2009;60(1-2):67-70. PMID 20205131.

Mueller I, Zimmerman PA, Reeder JC. Plasmodium malariae and Plasmodium ovale- the “bashful” malaria parasites. Trends Parasitol. 2007;23(6):278-83. doi: 10.1016/j.pt.2007.04.009, PMID 17459775.

Collins WE. Plasmodium knowlesi: a malaria parasite of monkeys and humans. Annu Rev Entomol. 2012;57:107-21. doi: 10.1146/annurev-ento-121510-133540, PMID 22149265.

Beare NA, Taylor TE, Harding SP, Lewallen S, Molyneux ME. Malarial retinopathy: a newly established diagnostic sign in severe malaria. Am J Trop Med Hyg. 2006;75(5):790-7. doi: 10.4269/ajtmh.2006.75.790, PMID 17123967.

World Health Organization. Malaria; 2021. Available from: https://www.who.int/news-room/fact-sheets/detail/malaria. [Last accessed on 15 Jun 2021]

Kementerian kesehatan republik indonesia. Profil kesehatan Indonesia tahun 2016. Jakarta: Kementerian Kesehatan RI; 2017.

World Health Organization. Health in 2015: from MDGs, Millennium Development Goals to SDGs, sustainable development goals. Available from: https://apps.who.int/iris/handle/10665/200009 [Last accessed on 18 Jun 2020]

Jawa Barat DKP, Jawa Barat Tahun PKP, Jawa Barat DKP; 2016.

Hakim L, Sugianto. Prevalensi malaria asymptomatic pada kelompok penduduk paling Berisiko Tertular di kecamatan Kalipucang kabupaten Ciamis jawa barat. Aspirator. 2009;1(1):04-10.

Hakim L. Tempat perindukan nyamuk Anopheles spp. Di kecamatan Kalipucang Kab. Ciamis. Bulletin Penyakit Tular Vektor (Vector Borne Disease). Loka Litbang P2B2 Ciamis. 2004;1(2):32-9.

Talisuna AO, Bloland P, D’Alessandro U. History, dynamics, and public health importance of malaria parasite resistance. Clin Microbiol Rev. 2004;17(1):235-54. doi: 10.1128/CMR.17.1.235-254.2004, PMID 14726463.

Olliaro PL, Bloland PB. Clinical and public health implications of antimalarial drug resistance. In: Rosenthal PJ, editor. Antimalarial chemotherapy: mechanisms of action, resistance, and new directions in drug discovery. Totowa, NJ: Humana Press; 2001.

Wellems TE, Plowe CV. Chloroquine-resistant malaria. J Infect Dis. 2001;184(6):770-6. doi: 10.1086/322858, PMID 11517439.

Widoyono. Penyakit Tropis: Epidemologi, Penularan, Pencegahan and Pemberantasannya. 2nd ed. Jakarta: Erlangga; 2011.

Etnofarmasi MM, ed. Vol. 1. Yogyakarta: Deepublish; 2012.

Hakim L, Malaria di Desa Pamotan FRP, Pangandaran K. ASPIRATOR-Jurnal penelitian penyakit tular Vektor. J Vector Borne Diseases Studies 2013;5(2):45-54.

Martin GJ. Ethnobotany: A methods manual. London: Chapman and Hall; 1995.

Cunningham BA. Applied ethnobotany people, wild plant use, and conservation. London: Earthscan Publications Ltd.; 2001.

Hoffman B, Gallaher T. Importance indices in ethnobotany. Ethnobot Res Appl. 2007;5:201-18. doi: 10.17348/era.5.0.201-218.

Farnsworth NR. Biological and phytochemical screening of plants. J Pharm Sci. 1966;55(3):225-76. doi: 10.1002/jps.2600550302, PMID 5335471.

Harborne JB. A guide to modern techniques of plant analysis. Phytochemical methods. 3rd ed. London, New York: Chapman and Hall; 1998.

Septiana E, Partomuan S. Toksisitas dan aktivitas antimalari penghambatan polimerisasi hem secara in vitro ekstrak daun sambiloto (Andrographis paniculata). Media Litbangkes. 2017;27(4):255-62.

Mishra K, Dash AP, Dey N. Andrographolide: A novel antimalarial diterpene lactone compound from Andrographis paniculata and its interaction with curcumin and artesunate. J Trop Med. 2011;2011:579518. doi: 10.1155/2011/579518.

Mutiah R, Badiah R, Hayati EK, Widyawaruyanti A. Activity of antimalarial compounds from ethyl acetate fraction of sunflower leaves (Helianthus annuus L.) against plasmodium falciparum parasites 3D7 Strain. Asian J Pharm Technol. 2017;7(2):61-5. doi: 10.5958/2231-5713.2017.00015.0.

Kovendan K, Murugan K, Panneerselvam C, Aarthi N, Kumar PM, Subramaniam J, Amerasan D, Kalimuthu K, Vincent S. Antimalarial activity of carica papaya (Family: Caricaceae) leaf extract against plasmodium falciparum. Asian Pac J Trop Dis. 2012;2(1):S306-11. doi: 10.1016/S2222-1808(12)60171-6.

Sannella AR, Karioti A, Orsini S, Scalone A, Gradoni L, Messori L, Severini C, Bilia AR. Leaf decoction of carica papaya combined with artesunate prevents recrudescence in Plasmodium berghei-infected mice. Planta Med. 2019;85(11-12):934-40. doi: 10.1055/a-0952-3677, PMID 31216580.

Longdet IY, Adoga EA. Effect of methanolic leaf extract of Carica papaya on Plasmodium berghei infection in albino mice. Eur J Med Plants. 2017;20(1):1-7. doi: 10.9734/EJMP/2017/34698.

Arifuddin M, Bone M, Rusli R, Kuncoro H, Ahmad I, Rijai L. Aktivitas Antimalaria penghambatan polimerisasi heme ekstrak etanol daun jambu biji (Psidium guajava) dan daun pepaya (Carica papaya). J Ilmiah Ibnu Sina. 2019;4(1):235-43. doi: 10.36387/jiis.v4i1.246.

Akanji OC, Cyril Olutayo CM, Elufioye OT, Ogunsusi OO. The antimalaria effect of Momordica charantia L. and Mirabilis jalapa leaf extracts using animal model. J Med Plants Res. 2016;10(24):344-50. doi: 10.5897/JMPR2016.6046.

Abdillah S, Farida Y, Kartiningsih SNMD, Mohamad K. Antimalarial activity and toxicity evaluation of the alkaloid-rich fraction of Momordica charantia fruits. Int J Pharm Sci Res. 2019;10(5):2516-22.

Niljan J, Jaihan U, Srichairatanakool S, Uthaipibull C, Somsak V. Antimalarial activity of stem extract of Tinospora crispa against plasmodium berghei infection in mice. J Health Res. 2014;28(3):199-204.

Rajendran C, Begam M, Kumar D, Baruah I, Gogoi HK, Srivastava RB, Veer V. Antiplasmodial activity of certain medicinal plants against chloroquine resistant Plasmodium berghei infected white albino BALB/c mice. J Parasit Dis. 2014;38(2):148-52. doi: 10.1007/s12639-013-0252-2, PMID 24808642.

Chinchilla M, Valerio I, Sanchez R, Mora V, Bagnarello V, Martinez L, Gonzalez A, Vanegas JC, Apestegui A. In vitro antimalarial activity of extracts of some plants from a biological reserve in Costa Rica. Rev Biol Trop. 2012;60(2):881-91. doi: 10.15517/rbt.v60i2.4024, PMID 23894953.

Lusakibanza M, Mesia G, Tona G, Karemere S, Lukuka A, Tits M, Angenot L, Frederich M. In vitro and in vivo antimalarial and cytotoxic activity of five plants used in congolese traditional medicine. J Ethnopharmacol. 2010;129(3):398-402. doi: 10.1016/j.jep.2010.04.007, PMID 20430094.

Sa MS, de Menezes MN, Krettli AU, Ribeiro IM, Tomassini TC, Ribeiro dos Santos R, et al. Antimalarial activity of physalins B, D, F, and G. J Nat Prod. 2011;74(10):2269-72. doi: 10.1021/np200260f, PMID 21954931.

Lisdawati V, Mutiartikum D, Alegantina S, Astuti Y, Miana KD. (Plectranthus scutellarioides (L.) Bth.) dan Buah Sirih (Piper betle L.) secara fisiko kimia dari ramuan lokal antimalaria daerah sulawesi utara. Media Litbang Kesehatan. 2008;18(4):213-25.

Kadota S, Marpaung L, Kikuchi T, Ekimoto H. Constituents of the seeds of Swietenia mahagoni Jacq. I. Isolation, structures, and 1H- and 13C-nuclear magnetic resonance signal assignments of new tetranortriterpenoids related to swietenine and swietenolide. Chem Pharm Bull. 1990;38(3):639-51. doi: 10.1248/cpb.38.639.

Tu Y. The discovery of artemisinin (qinghaosu) and gifts from Chinese medicine. Nat Med. 2011;17(10):1217-20. doi: 10.1038/nm.2471, PMID 21989013.

Klayman D. Qinghaosu (artemisinin): an antimalarial drug from. Chin Sci. 1998;228:1049.

Faurant C. From bark to weed: the history of artemisinin. Parasite. 2011;18(3):215-8. doi: 10.1051/parasite/2011183215, PMID 21894261.

Published

11-12-2021

How to Cite

TJITRARESMI, A., MOEKTIWARDOYO, M., & SUSILAWATI, Y. (2021). MEDICINAL HERBS USED IN MANAGEMENT OF MALARIA IN PAMOTAN VILLAGE COMMUNITY, KALIPUCANG DISTRICT, PANGANDARAN REGENCY, WEST JAVA, INDONESIA. International Journal of Applied Pharmaceutics, 13(4), 52–58. https://doi.org/10.22159/ijap.2021.v13s4.43816

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Section

Review Article(s)