FORMULATION AND ACTIVITY TEST OF SUNFLOWER OIL (HELIANTHUS ANNUUS L.) LIQUID SOAP AS ANTI ACNE

BENNI ISKANDAR; RANI SEPTIANA PUTRI; GRESSY NOVITA; MEIRCURIUS DWI CONDRO SURBOYO; LENY; CHING-KUO LEE

doi:10.22159/ijap.2022.v14s3.11

Authors

BENNI ISKANDAR Department of Pharmaceutical Technology, Sekolah Tinggi Ilmu Farmasi Riau (STIFAR), Pekanbaru, Riau, Indonesia, 28289, School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei, Taiwan, 11031
RANI SEPTIANA PUTRI Department of Pharmaceutical Technology, Sekolah Tinggi Ilmu Farmasi Riau (STIFAR), Pekanbaru, Riau, Indonesia, 28289
GRESSY NOVITA Department of Pharmaceutical Technology, Sekolah Tinggi Ilmu Farmasi Riau (STIFAR), Pekanbaru, Riau, Indonesia, 28289
MEIRCURIUS DWI CONDRO SURBOYO Department of Oral Medicine, Faculty of Dental Medicine, Airlangga University, Surabaya, Indonesia, 60132
LENY Faculty of Pharmacy and Health, Institute of Health Helvetia, Medan, Indonesia, 20124
CHING-KUO LEE School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei, Taiwan, 11031

DOI:

https://doi.org/10.22159/ijap.2022.v14s3.11

Keywords:

Liquid facial wash, Antibacterial, Propionibacterium acne, Sunflower oil

Abstract

Objective: This study aims to obtain a liquid soap containing sunflower oil which has a good physical characteristics and stability, also has potential as an antibacterial towards acne bacteria.

Methods: Sunflower oil is formulated into liquid facial wash with various concentrations 10% (F1); 15% (F2); and 20% (F3). Evaluation of preparations includes organoleptic test, pH value, specific gravity, viscosity, foaming ability, foam stability, freeze and thaw stability, and antibacterial activity against Propionibacterium acnes which causes acne by using the disc diffusion method. Data obtained was analyzed using Kruskal Wallis statistical test, One Way ANOVA, and descriptive test.

Results: Based on the results of the evaluation of the preparations, it was found that the organoleptic examination of F1, F2, and F3 liquid soap preparations had a thick liquid form, milky white in color, with the smell of rose. Liquid facial wash preparations of F1, F2, and F3 meet the evaluation requirements of pH, specific gravity, viscosity, ability to form foam, stable during storage in various degrees. Based on the analysis of the One Way ANOVA statistical test, there was a significant difference (p<0.05) in the diameter of the inhibition zone between each group of formulas.

Conclusion: It was concluded that the liquid facial wash preparations of sunflower oil F1, F2, and F3 were physically stable during storage, and based on the antibacterial activity test it was known that F3 had the greatest bacterial inhibition with a strong inhibition category (32.19±0.36 mm)

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