AMLODIPINE BESYLATE LOADED POLYMERIC NANOPARTICLES: PREPARATION AND IN VITRO CHARACTERISATION

DEEVAN PAUL A.; LAKSHMI K.; BRITO RAJ S.; BENOY VARGHESE CHERIYAN; KARTHIKEYAN R.

doi:10.22159/ijap.2022v14i6.45939

Authors

DEEVAN PAUL A. Chettinad School of Pharmaceutical Sciences, Chettinad Academy of Research and Education, Chennai 603103, India
LAKSHMI K. Chettinad School of Pharmaceutical Sciences, Chettinad Academy of Research and Education, Chennai 603103, India
BRITO RAJ S. Chettinad School of Pharmaceutical Sciences, Chettinad Academy of Research and Education, Chennai 603103, India
BENOY VARGHESE CHERIYAN Chettinad School of Pharmaceutical Sciences, Chettinad Academy of Research and Education, Chennai 603103, India
KARTHIKEYAN R. Chettinad School of Pharmaceutical Sciences, Chettinad Academy of Research and Education, Chennai 603103, India

DOI:

https://doi.org/10.22159/ijap.2022v14i6.45939

Keywords:

Polymeric nanoparticles, Optimization, In vitro drug release, Amlodipine besylate

Abstract

Objective: The present investigation aims to formulate the ideal drug formulation using different surfactants and optimize the amlodipine-loaded polymeric nanoparticles.

Methods: The present work was to formulate the drug-loaded polymeric nanoparticles to enhance the dissolution rate of a poorly water-soluble drug, amlodipine besylate, using the anti-solvent precipitation method. The Characterisation studies include particle size (nm), Zeta potential (mV), polydispersity index, Drug entrapment efficiency (%), in vitro release drug release, and surface morphological studies like SEM and XRD.

Results: The drug-loaded Polymeric nanoparticles of F3 containing PLGA and PVA shows the desired smaller particle size is 198.8±5.25, maximum zeta potential is-24.76±2.54 mv and the stable polydispersity index of 0.957±0.45. The drug entrapment efficiency is 93%, and the controlled dissolution of the ideal formulation pattern is about 94.88±2.45 in 24h.

Conclusion: The release pattern observed that PNs significantly improved the dissolution character of amlodipine besylate. PNs have a controlled drug release pattern and can be used as a suitable drug delivery carrier for low solubility and poorly bioavailable drugs like amlodipine to improve its dissolution rate.

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