• GAMAL OSMAN ELHASSAN Department of Pharmaceutics, Unaizah College of Pharmacy, Qassim University, Unaizah 51911, Saudi Arabia



Emulgel, Transdermal patch, Single-phase system, Release kinetics, Stability studies


Objective: Emulgel technique has attempts for preparation of itraconazole (ITZ) transdermal patches of reservoir type using a single-phase system with different polymers of Carbopol 934 and Carboxy methyl cellulose (CMC).

Methods: The transdermal patches were prepared by using eudragit L30 as a polymer and propylene glycol (PG) as plasticizer has been made to predict the mechanism of drug release and absorption based on the order of release. The optimized transdermal patches were characterised as surface morphology, pH, viscosity, spreadability, folding endurance, drug permeation, assay, in vitro dissolution and stability for 3 mo.

Results: The result of the study showed that the transdermal patches prepared with eudragit (8 %) showed 96.11±3.17 % drug release in 24 h and the optimised formulation F8, which had the highest concentration of span 20 and tween 20, displayed the highest percentage of drug penetration. The drug release kinetics was studied, including the Baker-Lonsdale model with in vitro drug permeation data was found that release from non-spherical matrices, the first-order model with non-fickian diffusion.

Conclusion: ITZ administered transdermally might be avoided the number of drawbacks associated with oral delivery and perhaps maintain a relatively constant plasma level during a lengthy course of treatment.


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Alqahtani A, Raut B, Khan S, Mohamed JMM, Fatease AA, Alqahtani T. The unique carboxymethyl fenugreek gum gel loaded itraconazole self-emulsifying nanovesicles for topical onychomycosis treatment. Polymers (Basel). 2022;14(2):325. doi: 10.3390/polym14020325, PMID 35054731.

Mohamed JMM, Ahamad F, El-Sherbiny M, Ebrahim HA, Eladl MA, Dawood AF. An ideal approach for enhancing 5-fluorouracil anticancer efficacy by nanoemulsion for cytotoxicity against a human hepatoma cell line (HepG2 cells). BioMed Res Int. 2022;2022:4094132. doi: 10.1155/2022/ 4094132, PMID 35757481.

Ashwathy P, Anto AT, Sudheesh MS. A mechanistic review on the dissolution phase behavior and supersaturation stabilization of amorphous solid dispersions. Drug Dev Ind Pharm. 2021;47(1):1-11. doi: 10.1080/03639045.2021.1879843, PMID 33494623.

Dawid Pac R. Medicinal plants used in the treatment of inflammatory skin diseases. Postepy Dermatol Alergol. 2013;30(3):170-7. doi: 10.5114/pdia.2013.35620, PMID 24278070.

Hua S. Physiological and pharmaceutical considerations for rectal drug formulations. Front Pharmacol. 2019;10:1196. doi: 10.3389/fphar.2019.01196, PMID 31680970.

Maddisetty PNP, Doss VA, SM, VS, TM. HPLC and GC-MS: identification and quantification of strychnine and brucine in strychnos nux-vomica leaves. Pak J Pharm Sci. 2017;30(6 Suppl):2369-73. PMID 29188771.

Mohanasundaram S, Doss VA, TA C, Prabhaharan J, Joseph V, Agilandeshwari S. Optimization of production of extracellular keratinase using streptomyces sp. isolated from poultry plant soil. Int J Res Pharm Sci. 2017;8(3):282-7.

Mohamed JMM, Alqahtani A, Ahmad F, Krishnaraju V, Kalpana K. Stoichiometrically governed curcumin solid dispersion and its cytotoxic evaluation on colorectal adenocarcinoma cells. Drug Des Devel Ther. 2020;14:4639-58. doi: 10.2147/DDDT.S273322. PMID 33173275.

Jamal Moideen MM, Alqahtani A, Venkatesan K, Ahmad F, Krisharaju K, Gayasuddin M. Application of the box-behnken design for the production of soluble curcumin: skimmed milk powder inclusion complex for improving the treatment of colorectal cancer. Food Sci Nutr. 2020;8(12):6643-59. doi: 10.1002/fsn3.1957, PMID 33312548.

Mohamed JM, Alqahtani A, Ahmad F, Krishnaraju V, Kalpana K. Pectin co-functionalized dual layered solid lipid nanoparticle made by soluble curcumin for the targeted potential treatment of colorectal cancer. Carbohydr Polym. 2021;252:117180. doi: 10.1016/j.carbpol.2020.117180. PMID 33183627.

Muthu MJ, Kavitha K, Chitra KS, Nandhineeswari S. Soluble curcumin prepared by solid dispersion using four different carriers: phase solubility, molecular modeling and physicochemical characterization. Trop J Pharm Res. 2019;18(8):1581-8. doi: 10.4314/tjpr.v18i8.2.

Sounder L, Doss VA, Mohanasundaram S. Acetaminophen-induced nephrotoxicity in experimental albino rats–histopathological study. Int J Res Pharm Sci. 2018;9(3):907-10.

Wang Q, Sivakumar K, Mohanasundaram S. Impacts of extrusion processing on food nutritional components. Int J Syst Assur Eng Manag. 2022;13(S1):364-74. doi: 10.1007/s13198-021-01422-2.

Shaik NB, Gera S, Kukati L, Goverdhanam H. Formulation and evaluation of emulgel of flurbiprofen. Int Res J Pharm. 2019;10(8):68-76. doi: 10.7897/2230-8407.1008248.

Salamanca CH, Barrera Ocampo A, Lasso JC, Camacho N, Yarce CJ. Franz diffusion cell approach for pre-formulation characterization of ketoprofen semi-solid dosage forms. Pharmaceutics. 2018;10(3):148. doi: 10.3390/ pharmaceutics10030148, PMID 30189634.

Mohamed JMM, Alqahtani A, Al Fatease A, Alqahtani T, Khan BA, Ashmitha B. Human hair keratin composite scaffold: characterisation and biocompatibility study on NIH 3T3 fibroblast cells. Pharmaceuticals (Basel). 2021;14(8):781. doi: 10.3390/ph14080781, PMID 34451878.

Maddisetty P, Doss VA, Mohanasundaram S. Analysis of strychnine and brucine in hydroethanolic extract of strychnos nux–vomica leaves by using HPTLC. Int J Res Pharm Sci. 2016;8(1):78-81.

Mohamed JMM, Alqahtani A, Khan BA, Al Fatease A, Alqahtani T, Venkatesan K. Preparation of soluble complex of curcumin for the potential antagonistic effects on human colorectal adenocarcinoma cells. Pharmaceuticals (Basel). 2021;14(9):939. doi: 10.3390/ph14090939, PMID 34577638.

Parhi R, Padilam S. In vitro permeation and stability studies on the developed drug-in-adhesive transdermal patch of simvastatin. Bull Fac Pharm Cairo Univ. 2018;56(1):26-33. doi: 10.1016/j.bfopcu.2018.04.001.

Sounder L, Doss VA, Mohanasundaram S. Analysis of hydroethanolic leaf extract of Aerva lanata (L.) in screening antioxidant activity and in vitro antibacterial efficacy. Int J Res Pharm Sci. 2018;9(3):911-5.

Mohamed JMM, Ahmad F, Alqahtani A, Lqahtani T, Raju VK, Anusuya M. Studies on preparation and evaluation of soluble 1:1 stoichiometric curcumin complex for colorectal cancer treatment. Trends Sci. 2021;18(24):1403. doi: 10.48048/ tis.2021.1403.

Muthu JM, Ahmad F, Kishore N, Al-Subaie AM. Soluble 1: 1 stoichiometry curcumin binary complex for potential apoptosis in human colorectal adenocarcinoma cells (SW480 and Caco-2 cells). Res J Pharm Technol. 2021;14(1):129-35. doi: 10.5958/0974-360X.2021.00023.8.

Ujjan JA, Morani W, Memon N, Mohanasundaram S, Nuhmani S, Singh BK. Force platform-based intervention program for individuals suffering with neurodegenerative diseases like Parkinson. Comput Math Methods Med. 2022. p. 11. doi: 10.1155/2022/1636263, PMID 35082910.

Kalyanwat R, Shrivastava B, Pathak K. Preparation and evaluation of bioadhesive ocular inserts of aceclofenac. International Journal of Pharmaceutical Sciences Review and Research. 2016;41:207-213.

Mohamed JMM, Alqahtani A, Kumar TVA, Fatease AA, Alqahtani T, Krishnaraju V, Fazil Ahmad F, Menaa F, Alamri A, Muthumani R, Vijaya R. Superfast synthesis of stabilized silver nanoparticles using aqueous allium sativum (Garlic) extract and isoniazid hydrazide conjugates: molecular docking and in vitro characterizations. Molecules. 2022;27(1):110. doi: 10.3390/molecules27010110, PMID 35011342.

Mohamed JMM, Mahajan N, El-Sherbiny M, Khan S, Al-Serwi RH, Attia MA, Altriny QA, Arbab AH. Ameliorated stomach-specific floating microspheres for emerging health pathologies using polymeric konjac glucomannan-based domperidone. BioMed Research International. 2022:1-12. 10.1155/2022/3670946.



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